Does inhalation of ultrafine particles cause pulmonary vasular effects in humans?

Inhalation Toxicology

Volumn 19, Issue SUPPL. 1, 2007, Pages 75-79

  Frampton, Mark W ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CELL ADHESION MOLECULE;

AIR QUALITY STANDARD; AMBIENT AIR; ASTHMA; CARDIOVASCULAR RISK; CONFERENCE PAPER; ENVIRONMENTAL EXPOSURE; HUMAN; INHALATION; LEUKOCYTE; LUNG BLOOD VESSEL; LUNG DIFFUSION CAPACITY; LUNG FUNCTION; PARTICULATE MATTER; PREDICTION; PRIORITY JOURNAL; PULMONARY ARTERY DISEASE; RESPIRATORY SYSTEM;

CARDIOVASCULAR SYSTEM; EXERCISE; HUMANS; INHALATION EXPOSURE; LUNG DISEASES; PARTICLE SIZE; PARTICULATE MATTER; RESPIRATORY MECHANICS;

EID: 34548833609     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370701495071     Document Type: Conference Paper

References (29)

1. Anderson, G. J., Roswit, W. T., Holtzman, M. J., Hogg, J. C., and Van Eeden, S. F. 2001. Effect of mechanical deformation of neutrophils on their CD18/ICAM-1-dependent adhesion. J. Appl. Physiol. 91:1084-1090.
2. Batalha, J. R., Saldiva, P. H., Clarke, R. W., Coull, B. A., Stearns, R. C., Lawrence, J., Murthy, G. G., Koutrakis, P., and Godleski, J. J. 2002. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ. Health Perspect. 110:1191-1197.
3. Beckett, W. S., Chalupa, D. F., Pauly-Brown, A., Speers, D. M., Stewart, J. C., Frampton, M. W., Utell, M. J., Huang, L.-S., Cox, C., Zareba, W., and Oberdörster, G. 2005. Comparison of inhaled ultrafine vs. fine zinc oxide particles in healthy adults: A human inhalation study. Am. J. Respir. Crit. Care Med. 171:1129-1135.
4. Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., and Donaldson, K. 2001. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol. 175:191-199.
5. Chalupa, D. C., Morrow, P. E., Oberdörster, G., Utell, M. J., and Frampton, M. W. 2004. Ultrafine particle deposition in subjects with asthma. Environ. Health Perspect. 112:879-882.
6. Chalupa, D. F., Gibb, F. R., Morrow, P. E., Oberdörster, G., Riesenfeld, E., Gelein, R., Utell, M. J., and Frampton, M. W. 2002. A facility for controlled human exposures to ultrafine particles. In Crucial issues in inhalation research - Mechanistic, clinical and epidemiologic, eds. U. Heinrich and U. Mohr, pp. 241-253. Washington, DC:ILSI Press.
7. Daigle, C. C., Chalupa, D. C., Gibb, F. R., Morrow, P. E., Oberdörster, G., Utell, M. J., and Frampton, M. W. 2003. Ultrafine particle deposition in humans during rest and exercise. Inhal. Toxicol. 15:539-552.
8. Dick, C. A., Brown, D. M., Donaldson, K., and Stone, V. 2003. The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types. Inhal. Toxicol. 15:39-52.
9. Doerschuk, C. M. 2003. Neutrophil emigration in the lungs. In Therapeutic targets in airway inflammation, eds. T. Eissa and D. P. Huston, pp. 249-280. New York: Marcel Dekker,
10. Dominici, F., Peng, R. D., Bell, M. L., Pham, L., McDermott, A., Zeger, S. L., and Samet, J. M. 2006. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. J. Am. Med. Assoc. 295:1127-1134.
11. Elder, A., Gelein, R., Silva, V., Feikert, T., Opanashuk, L., Carter, J., Potter, R., Maynard, A., Ito, Y., Finkelstein, J., and Oberdorster, G. 2006. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ. Health Perspect. 114:1172-1178.
12. Frampton, M. W., Pietropaoli, A. P., Morrow, P. E., and Utell, M. J. 2006a. Human clinical studies of airborne pollutants. In Toxicology of the lung, ed. D. E. Gardner, pp. 29-82. Boca Raton, FL:CRC Press.
13. Frampton, M. W., Stewart, J. C., Oberdörster, G., Morrow, P. E., Chalupa, D., Pietropaoli, A. P., Frasier, L. M., Speers, D. M., Cox, C., Huang, L.-S., and Utell, M. J. 2006b. Inhalation of carbon utrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ. Health Perspect. 114:51-58.
14. Geiser, M., Rothen-Rutishauser, B., Kapp, N., Schurch, S., Kreyling, W., Schulz, H., Semmler, M., Im Hof, V., Heyder, J., and Gehr, P. 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 113:1555-1560.
15. Godleski, J. J. 2006. Responses of the heart to ambient particle inhalation. Clin. Occup. Environ. Med. 5:849-864.
16. ICRP. 1994. Human respiratory tract model for radiological protection. Publication no. 66. Tarrytown, NY: International Commission on Radiological Protection, Elsevier Science Ltd.
17. Künzli, N., Jerrett, M., Mack, W. J., Beckerman, B., LaBree, L., Gilliland, F., Thomas, D., Peters, J., and Hodis, H. N. 2005. Ambient air pollution and atherosclerosis in Los Angeles. Environ. Health Perspect. 113:201-206.
18. Markos, J., Doerschuk, C. M., English, D., Wiggs, B. R., and Hogg, J. C. 1993. Effect of positive end-expiratory pressure on leukocyte transit in rabbit lungs. J. Appl. Physiol. 74:2627-2633.
19. Markos, J., Hooper, R. O., Kavanagh-Gray, D., Wiggs, B. R., and Hogg, J. C. 1990. Effect of raised alveolar pressure on leukocyte retention in the human lung. J. Appl. Physiol. 69:214-221.
20. Mills, N. L., Amin, N., Robinson, S. D., Anand, A., Davies, J., Patel, D., de la Fuente, J. M., Cassee, F. R., Boon, N. A., Macnee, W., Millar, A. M., Donaldson, K., and Newby, D. E. 2006. Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am. J. Respir. Crit. Care Med. 173:426-431.
21. Nemmar, A., Hoet, P. H., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., and Nemery, B. 2002. Passage of inhaled particles into the blood circulation in humans. Circulation 105:411-414.
22. Phalen, R. F., and Oldham, M. J. 2006. Aerosol dosimetry considerations. Clin. Occup. Environ. Med. 5:773-784.
23. Pietropaoli, A. P., Frampton, M. W., Hyde, R. W., Morrow, P. E., Oberdörster, G., Cox, C., Speers, D. M., Frasier, L. M., Chalupa, D. C., Huang, L.-S., and Utell, M. J. 2004a. Pulmonary function, diffusing capacity and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal. Toxicol. 16(suppl. 1):59-72.
24. Pietropaoli, A. P., Frampton, M. W., Oberdörster, G., Cox, C., Huang, L.-S., Marder, V., and Utell, M. J. 2004b. Blood markers of coagulation and inflammation in healthy human subjects exposed to carbon ultrafine particles. In Effects of air contaminants on the respiratory tract - Interpretations from molecular to meta analysis, ed. U. Heinrich, pp. 181-194. Stuttgart, Germany: INIS Monographs, Fraunhofer IRB Verlag,
25. Schwartz, J. 2006. Long-term effects of exposure to particulate air pollution. Clin. Occup. Environ. Med. 837-848.
26. Utell, M. J., and Frampton, M. W. 1995. Particles and mortality: A clinical perspective. Inhal. Toxicol. 7:645-655.
27. Utell, M. J., Frampton, M. W., Zareba, W., Devlin, R. B., and Cascio, W. E. 2002. Cardiovascular effects associated with air pollution: Potential mechanisms and methods of testing. Inhal. Toxicol. 14:1231-1247.
28. van Eeden, S. F., Granton, J., Hards, J. M., Moore, B., and Hogg, J. C. 1999. Expression of the cell adhesion molecules on leukocytes that demarginate during acute maximal exercise. J. Appl. Physiol. 86:970-976.
29. Xia, T., Kovochich, M., and Nel, A. 2006. The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. Clin. Occup. Environ. Med. 5:817-836.