Concentration dependence of a poly-leucine surfactant protein C analogue on in vitro and in vivo surfactant activity

Neonatology

Volumn 92, Issue 3, 2007, Pages 194-200

  Almlén, Andreas ^a   Stichtenoth, Guido ^a   Robertson, Bengt ^a   Johansson, Jan ^b   Curstedt, Tore ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Membrane protein; Neonatal respiratory distress syndrome; Pulmonary surfactant; Synthetic peptide

Indexed keywords

1 PALMITOYL 2 OLEOYLGLYCERO 3 PHOSPHOGLYCEROL; 1,2 DIPALMITOYL GLYCERO 3 PHOSPHOCHOLINE; CHOLINE DERIVATIVE; GLYCEROL DERIVATIVE; LUNG SURFACTANT; PEPTIDE SP C33; POLY LEUCINE; SURFACTANT PROTEIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FETUS; FETUS LUNG MATURATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SURFACE TENSION;

ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; FORCED EXPIRATORY FLOW RATES; LUNG; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; RABBITS; RESPIRATION, ARTIFICIAL; SURFACE TENSION; TIDAL VOLUME;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 34548832238     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000102057     Document Type: Article

References (32)

1. Goerke J: Pulmonary surfactant: functions and molecular composition. Biochim Biophys Acta 1998;1408:79-89.
2. Johansson J, Curstedt T: Molecular structures and interactions of pulmonary surfactant components. Eur J Biochem 1997;244:675-693.
3. Robertson B, Johansson J, Curstedt T: Synthetic surfactants to treat neonatal lung disease. Mol Med Today 2000;6:119-124.
4. Spragg RG, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF, Witte MC, Richards GA, Rippin G, Rathgeb F, Hafner D, Taut FJ, Seeger W: Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med 2004;351:884-892.
5. Cochrane CG, Revak SD: Pulmonary surfactant protein B (SP-B): structure-function relationships. Science 1991;254:566-568.
6. Bernhard W, Mottaghian J, Gebert A, Rau GA, von der Hardt H, Poets CF: Commercial versus native surfactants. Surface activity, molecular components, and the effect of calcium. Am J Respir Crit Care Med 2000;162:1524-1533.
7. Whitsett JA, Weaver TE: Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 2002;347:2141-2148.
8. Nogee LM, de Mello DE, Dehner LP, Colten HR: Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis. N Engl J Med 1993;328:406-410.
9. Clark JC, Wert SE, Bachurski CJ, Stahlman MT, Stripp BR, Weaver TE, Whitsett JA: Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci USA 1995;92:7794-7798.
10. Vorbroker DK, Profitt SA, Nogee LM, Whitsett JA: Aberrant processing of surfactant protein C in hereditary SP-B deficiency. Am J Physiol 1995;268: L647-L656.
11. Beers MF, Hamvas A, Moxley MA, Gonzales LW, Guttentag SH, Solarin KO, Longmore WJ, Nogee LM, Ballard PL: Pulmonary surfactant metabolism in infants lacking surfactant protein B. Am J Respir Cell Mol Biol 2000;22:380-391.
12. Li J, Ikegami M, Na CL, Hamvas A, Espinassous Q, Chaby R, Nogee LM, Weaver TE, Johansson J: N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide binding. Biochemistry 2004;43:3891-3898.
13. Glasser SW, Burhans MS, Korfhagen TR, Na CL, Sly PD, Ross GF, Ikegami M, Whitsett JA: Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc Natl Acad Sci USA 2001;98:6366-6371.
14. Glasser SW, Detmer EA, Ikegami M, Na CL, Stahlman MT, Whitsett JA: Pneumonitis and emphysema in SP-C gene targeted mice. J Biol Chem 2003;278:14291-14298.
15. Curstedt T, Johansson J, Persson P, Eklund A, Robertson B, Lowenadler B, Jornvall H: Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups. Proc Natl Acad Sci USA 1990;87:2985-2989.
16. Johansson J, Szyperski T, Curstedt T, Wuthrich K: The NMR structure of the pulmonary surfactant-associated polypeptide SP-C in an apolar solvent contains a valyl-rich alpha-helix. Biochemistry 1994;33:6015-6023.
17. Plasencia I, Rivas L, Keough KM, Marsh D, Perez-Gil J: The N-terminal segment of pulmonary surfactant lipopeptide SP-C has intrinsic propensity to interact with and perturb phospholipid bilayers. Biochem J 2004;377:183-193.
18. Johansson J, Nilsson G, Stromberg R, Robertson B, Jornvall H, Curstedt T: Secondary structure and biophysical activity of synthetic analogues of the pulmonary surfactant polypeptide SP-C. Biochem J 1995;307:535-541.
19. Szyperski T, Vandenbussche G, Curstedt T, Ruysschaert JM, Wuthrich K, Johansson J: Pulmonary surfactant-associated polypeptide C in a mixed organic solvent transforms from a monomeric α-helical state into insoluble β-sheet aggregates. Protein Sci 1998;7:2533-2540.
20. Gustafsson M, Thyberg J, Naslund J, Eliasson E, Johansson J: Amyloid fibril formation by pulmonary surfactant protein C. FEBS Lett 1999;464:138-142.
21. Luy B, Diener A, Hummel RP, Sturm E, Ulrich WR, Griesinger C: Structure and potential C-terminal dimerization of a recombinant mutant of surfactant-associated protein C in chloroform/methanol. Eur J Biochem 2004;271:2076-2085.
22. Kallberg Y, Gustafsson M, Persson B, Thyberg J, Johansson J: Prediction of amyloid fibril-forming proteins. J Biol Chem 2001;276:12945-12950.
23. Nilsson G, Gustafsson M, Vandenbussche G, Veldhuizen E, Griffiths WJ, Sjovall J, Haagsman HP, Ruysschaert JM, Robertson B, Curstedt T, Johansson J: Synthetic peptide-containing surfactants - Evaluation of transmembrane versus amphipathic helices and surfactant protein C poly-valyl to poly-leucyl substitution. Eur J Biochem 1998;255:116-124.
24. Johansson J, Some M, Linderholm BM, Almlen A, Curstedt T, Robertson B: A synthetic surfactant based on a poly-Leu SP-C analog and phospholipids: effects on tidal volumes and lung gas volumes in ventilated immature newborn rabbits. J Appl Physiol 2003;95:2055-2063.
25. Stark M, Wang Y, Danielsson O, Jornvall H, Johansson J: Determination of proteins, phosphatidylethanolamine, and phosphatidylserine in organic solvent extracts of tissue material by analysis of phenylthiocarbamyl derivatives. Anal Biochem 1998;265:97-102.
26. Schurch S, Bachofen H, Goerke J, Possmayer F: A Captive bubble method reproduces the in situ behaviour of lung surfactant monolayers. J Appl Physiol 1989;67:2389-2396.
27. Enhörning G: Pulsating bubble technique for evaluating pulmonary surfactant. J Appl Physiol 1977;43:198-203.
28. Putz G, Goerke J, Taeusch HW, Clements JA: Comparison of captive and pulsating bubble surfactometers with use of lung surfactants. J Appl Physiol 1994;76:1425-1431.
29. Scherle W: A simple method for volumetry of organs in quantitative sterology. Mikroskopie 1970;26:57-60.
30. Berggren P, Rigaut JP, Curstedt T, Robertson B: Computerized image analysis of lung expansion patterns in surfactant treated immature newborn rabbits. Respir Physiol 1999;115:45-53.
31. Nilsson R, Grossman G, Robertson B: Artificial ventilation of premature newborn rabbits; effects of positive end-expiratory pressure on lung mechanics and lung morphology. Acta Paediatr Scand 1980;69:597-602.
32. Davis AJ, Jobe AH, Hafner D, Ikegami M: Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant. Am J Respir Crit Care Med 1998;157:553-559.