Chlamydia trachomatis infection of human trophoblast alters estrogen and progesterone biosynthesis: An insight into role of infection in pregnancy sequelae

International Journal of Medical Sciences

Volumn 4, Issue 4, 2007, Pages 223-231

  Azenabor, Anthony A ^a   Kennedy, Patrick ^a   Balistreri, Salvatore ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Chlamydia and pregnancy outcome; Chronic chlamydia in trophoblast; Steroid hormones; Trophoblast function

Indexed keywords

AROMATASE; CHORIONIC GONADOTROPIN; ESTROGEN; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; HEAT SHOCK PROTEIN 60; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PROGESTERONE;

ARTICLE; CELL FUNCTION; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CHOLESTEROL SYNTHESIS; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ESTROGEN SYNTHESIS; HEP 2 CELL; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; IMPLANTATION; PREGNANCY; PROGESTERONE SYNTHESIS; PROTEIN EXPRESSION; REPRODUCTION; TITRIMETRY; TROPHOBLAST; UPREGULATION;

EID: 34548800906     PISSN: None     EISSN: 14491907     Source Type: Journal    
DOI: 10.7150/ijms.4.223     Document Type: Article

References (37)

1. Bevilacqua E., and Abahamsohn P.A. Ultrastructure of trophoblast giant cell transformation during the invasive stage of implantation of the mouse embryo. J. Morphology. 1988;198: 341-351.
2. Mehrotra P.K. Ultrastructure of mouse ectoplacental cone cells. Biol. Struct. Morph. 1988;1: 63-68.
3. Kanai-Azuma M., Kanai Y., Kurohmaru M., Tachi C., Yazaki K., and Hayashi Y. Giant cells transformation of trophoblast cells in mice. Endocrine J. 1994;41: 33-41.
4. Loke YW and King A. Human Implantation. Cambridge: Cambridge University Press. 1995
5. Manyonda I.T., Slater D.M., Fenske C., Hole D., Choy M.Y., and Wilson C. A role for noradrenaline in pre-eclampsia: towards a unifying hypothesis for the pathophysiology. Br. J. Obstet. Gynaecol. 1998;105: 641-648.
6. Katsuragawa H., Rote N.S., Inoue T., Narukawa S., Kanzaki H., and Mori T. Monoclonal antiphosphatidylserine antibody reactivity against human first-trimester placental trophoblasts. Am. J. Obstet. Gynecol. 1995;172: 1592-1597.
7. Sugimura M., Kobayashi T., Shu F., Kanayama N., and Terao T. Annexin V inhibits phosphatidylserine-induced intrauterine growth restriction in mice. Placenta. 1999;20: 555-560.
8. Kanenishi K., Kuwabara H., Ueno M., Sakamoto H., and Hata T. Immunohistochemical adrenomedullin expression is decreased in the placenta from pregnancies with pre-eclampsia. Pathol. Int. 2000;50: 536-540.
9. Page N.M., Woods R.J., Gardiner S.M., Lomthaisong K., Gladwell R.T., Butlin D.J., et al. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature. 2000;405: 797-800.
10. Holland M.J., Bailey R.L., Hayes L.J., Whittle H.C., and Mabey D.C.W. Conjunctival scarring in trachoma is associated with depressed cell-mediated immune responses to chlamydial antigens. J. Infect. Dis. 1993;168: 1528-1531.
11. Marais N.F., Wessels P.H., Smith M.S., and Gericke G.A. Prevalence of Chlamydia trachomatis infection in new patients at the infertility clinic. S. Afr. Med. J. 1990;77: 232-233.
12. Chow J.N., Yenekura N.L., Richwald G.A., Greenland S., Sweet R.L., and Schachter J. The association between Chlamydia trachomatis and ectopic pregnancy. A matched-pair, case-control study. JAMA. 1990;263: 3191-3192.
13. Beatty W.L., Morrison R.P., and Byrne G.L. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol. Rev. 1994;58: 686-699.
14. Macauley M.E., Riordan T., James J.M., Laventhall P.A., Morris E.M., Neal B.R, et al. A prospective study of genital infections in a family planning clinic. Epidemiol. Infect. 1990;104: 55-61.
15. Azenabor A.A., and Eghafona N.O. Association of Chlamydia trachomatis antibodies with genital contact disease in women in Benin City, Nigeria. Tropical Medicine and International Health. 1997;2: 389-392.
16. Roberts W., Grist N.R., and Giroud P. Human abortion associated with infection by ovine abortion agent. Br. Med. J. 1967;4: 37.
17. Johnson, F.W.A., Matheson B.A., Williams H., Laing A.G., Jandial V., Davidson-Lamb R., Halliday G.J., Hobson D., Wong S.Y., Hadley K.M., Moffat, M.A.J., and Postlethwaite R. Abortion due to infection with Chlamydia psittaci in a sheep farmer's wife. Br. Med. J. 1985;290: 592-594.
18. Caldwell H.D., Kromhout J., and Schachter J. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect. Immun. 1981;31: 1161-1176.
19. Azenabor A.A., and Chaudhry A.U. Chlamydia pneumoniae survival in macrophages is regulated by free Ca2+ dependent reactive nitrogen and oxygen species. J. Infect. 2003;46: 120-128.
20. Amundson D.M., and Zhou M. Fluorimetric method for the enzymatic determination of cholesterol. J. Biochem. Biophys. Methods. 1999;38: 43-52.
21. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H, Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., and Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 1985;150: 76-85.
22. Erickson G.F. The ovary: basic principles and concepts. A. physiology. In: Felig P., Baxter J.D., Frohman L.A., eds. Endocrinology and metabolism. New York: McGraw-Hill. 1995:973-1015.
23. Azenabor A.A., Job G, and Adedokun O.O. Chlamydia pneumoniae infected macrophages exhibit enhanced plasma membrane fluidity and show increased adherence to endothelial cells. Mol. and Cell. Biochem. 2005;269: 69-84.
24. Azenabor A.A., Muili K., Akoachere J.F., and Chaudhry A. Macrophage antioxidant enzymes regulate Chlamydia pneumoniae chronicity: Evidence of redox balance on host-pathogen relationship. Immunobiol. 2006;211: 325-329.
25. Morrison R.P. Chlamydial hsp60 and the immunopathogenesis of chlamydial disease. Seminars in Immunology. 1991;3: 25-33.
26. Gagioti S., Colepicolo P., and Bevilacqua E. Post implantation mouse embryos have the capability to generate and release reactive oxygen species. Reprod. Fertil. Dev. 1995;7: 1111-1116.
27. Gagioti S., Colepicolo P., and Bevilacqua E. Reactive oxygen species and the phagocytosis process of hemochorial trophoblast. Ciencia e Cultura. 1996;48: 37-42.
28. Gagioti S., Scavone C., and Bevilacqua E. Participation of the mouse implanting trophoblast in nitric oxide production during pregnancy. Biol. Reprod. 2000;62: 260-268.
29. Azenabor A.A., Chaudhry A.U. and Yang S. Macrophage L-type Ca2+ channel antagonists alter Chlamydia pneumoniae MOMP and HSP-60 mRNA gene expression, and improve antibiotic susceptibility. Immunobiol. 2003;207: 237-245.
30. Carabeo R.A., Mead D.J., and Hackstadt T. Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion. Proc. Natl. Acad. Sci. 2003;100: 6771-6776.
31. Kam, E.P.Y., Gardner L., Loke Y.W., and King A. The role of trophoblast in the physiological change in decidual spiral arteries. Hum. Reprod. 1999;14: 2131-2138.
32. Lunghi L., Ferretti M.E., Medici S., Biondi C., and Vesce F. Control of human trophoblast function. Reprod. Biol. Endocrinol. 2007; 5: 6.
33. Khong T.Y., de Wolf F., Robertson W.B., and Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br. J. Obstet. Gyanaecol. 1986;93: 1049-1059.
34. Pridjian G., and Puschett J.B. Preeclampsia. Part 1: clinical and pathophysiologic considerations. Obstet Gynecol Surv. 2002;57: 598-618.
35. Pridjian G., and Puschett J.B. Preeclampsia. Part 2: experimental and genetic considerations. Obstet Gynecol Surv. 2002;57: 619-640.
36. Reshef E. Lei Z.M., Rao C.V., Pridham D.D., Chegini N., and Luborsky J.L. The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes and decidua. J. Clin. Endocrinol. Metab. 1990;70: 421-430.
37. Equils O., Lu D., Gatter M., Witkin S.S., Bertolotto C., Arditi M., McGregor J.A., Simmons C.F., and Hobel C.J. Chlamydial Heat Shock Protein 60 Induces Trophoblast Apoptosis through TLR4. J. Immunol. 2006;177: 1257-1263.