Activity of iclaprim against Legionella pneumophila [2]

Journal of Antimicrobial Chemotherapy

Volumn 60, Issue 4, 2007, Pages 905-906

  Morrissey, Ian ^a   Hawser, Stephen ^b  

^a GR Micro Ltd   (United Kingdom)

^b Arpida Ltd   (Switzerland)

Author keywords

Atypical; L. pneumophila; RTIs

Indexed keywords

CLARITHROMYCIN; COTRIMOXAZOLE; ICLAPRIM; LEVOFLOXACIN; SULFAMETHOXAZOLE; TRIMETHOPRIM;

BACTERIAL COLONIZATION; BACTERIUM ISOLATE; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; DILUTION; DRUG BIOAVAILABILITY; DRUG POTENCY; EPITHELIUM; HAEMOPHILUS INFLUENZAE; IN VITRO STUDY; INOCULATION; LEGIONELLA PNEUMOPHILA; LETTER; LUNG ALVEOLUS MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RESPIRATORY TRACT INFECTION; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; HUMANS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MICROBIAL SENSITIVITY TESTS; PYRIMIDINES;

EID: 34548794746     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm288     Document Type: Letter

References (5)

1. Sabria M, Campins M. Legionnaires' disease: Update on epidemiology and management options. Am J Respir Med 2003; 2: 235-43.
2. Mandell LA, Bartlett JG, Dowell SF et al. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 2003; 37: 1405-33.
3. Andrews JM, Honeybourne D, Ashby JP. Concentrations of iciaprim in plasma, epithelial lining fluid (elf) alveolar macrophages (am) and bronchial mucosa (bm) following a single 1.6 mg/kg intravenous infusion in healthy subjects. In: Abstracts of the Forty-fifth Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, 2005. Abstract A-9, p. 2. American Society for Microbiology, Washington, DC, USA.
4. Hawser S, Lociuro S, Islam K. Dihydrofolate reductase inhibitors as antibacterial agents. Biochem, Pharmacol 2006; 71: 941-8.
5. Kohlhoff SA, Roblin PM, Reznik T et al. In vitro activity of a novel diaminopyrimidine compound, iclaprim, against Chlamydia trachomatis and C. pneumoniae. Antimicrob Agents Chemother 2004; 48: 1885-6.