Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K

General Physiology and Biophysics

Volumn 26, Issue 2, 2007, Pages 104-109

  Feng, Y ^a   Cao, H Q ^b   Liu, Z ^a   Ding, J F ^b   Meng, Xian Min ^b  

^a TONGJI UNIVERSITY   (China)

^b FUWAI HOSPITAL   (China)

Author keywords

Ankyrin repeats; Cardiac troponin I interacting kinase; Mixed lineage kinase; Protein kinase; Ser rich domain

Indexed keywords

ANKYRIN; DIMER; OLIGOMER; PROTEIN KINASE; TROPONIN I INTERACTING KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN;

AMINO ACID MOTIFS; CELL LINE, TRANSFORMED; CLONING, MOLECULAR; DIMERIZATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE KINASE KINASES; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN HYBRIDIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 34548789645     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Bloem L. J., Pickard T. R., Acton S., Donoghue M., Beavis R. C., Knierman M. D., Wang X. (2001): Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. J. Mol. Cell. Cardiol. 33, 1739-1750
2. 2+/calmodulin-dependent protein kinase type IV/GR. J. Biol. Chem. 271, 21542-21548
3. Fan G., Merritt S. E., Kortenjann M., Shaw P. E., Holzman L. B. (1996): Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2. J. Biol. Chem. 271, 24788-24793
4. Galio K. A., Mark M. R., Scadden D. T., Wang Z., Gu Q., Godowski P. J. (1994): Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/ threonine kinase activity. J. Biol. Chem. 269, 15092-15100
5. Gotoh Y., Cooper J. A. (1998): Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction. J. Biol. Chem. 273, 17477-17482
6. Hannigan G. E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M. G., Radeva G., Filmus J., Bell J. C., Dedhar S. F. (1996): Regulation of cell adhesion and anchorage-dependent growth by a new β-1-integrin-linked protein kinase. Nature 379, 91-96
7. Hirai S., Katoh M., Terada M., Kyriakis J. M., Zon L. I., Rana A., Avruch J., Ohno S. (1997): MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 272, 15167-15173
8. Holzman L. B., Merritt S. E., Fan G. (1994): Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases. J. Biol. Chem. 269, 30808-30817
9. Ikeda A., Masaki M., Kozutsumi Y., Oka S., Kawasald T. (2001): Identification and characterization of functional domains in a mixed lineage kinase LZK. FEBS Lett. 488, 190-195
10. King C. C., Zenke F. T., Dawson P. E., Dutil E. M., Newton A. C., Hemmings B. A., Bokoch G. M. (2000): Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J. Biol. Chem. 275, 18108-18113
11. Leung I. W., Lassam N. (1998): Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK- 3. J. Biol. Chem. 273, 32408-32415
12. Liu T. C., Huang C. J., Chu Y. C., Wei C. C., Chou C. C., Chou M. Y., Chou C. K., Yang J. J. (2000): Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-α motif. Biochem. Biophys. Res. Commun. 274, 811-816
13. Manning G., Whyte D. B., Martinez R. (2002): The protein kinase complement of the human genome. Science 298, 912-934
14. Mata M., Merritt S. E., Fan G., Yu G. G., Holzman L. B. (1996): Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin. J. Biol. Chem. 271, 16888-16896
15. Nihalani D., Merritt S., Holzman L. B. (2000): Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation. J. Biol. Chem. 275, 7273-7279
16. Rana A., Gallo K., Godowski P., Hirai S., Ohno S., Zon L., Kyriakis J. M., Avruch J. (1996): The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J. Biol. Chem. 271, 19025-19028
17. Raveh T., Berissi H., Eisenstein M., Spivak T., Kimchi A. (2000): A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 97, 1572-1577
18. Sakuma H., Ikeda A., Oka S., Kozutsumi Y., Zanetta J. P., Kawasaki T. (1997): Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. J. Biol. Chem. 272, 28622-28629
19. Shohat G., Spivak-Kroizman T., Cohen O., Bialik S., Shani G., Berrisi H., Eisenstein M., Kimchi A. (2001): The proapoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. J. Biol. Chem. 276, 47460-47467
20. Vacratsis P. O., Gallo K. A. (2000): Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but is necessary for its activation of the INK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylation of Thr258 of murine MITOGEN-ACTIVATED protein kinase kinase 4. J. Biol. Chem. 275, 27893-27900
21. Yamaguchi K., Shirakabe K., Shibuya H., Irie K., Oishi I., Ueno N., Taniguchi T., Nishida E., Matsumoto K. (1995): Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270, 2008-2011
22. Yustein J. T., Li D., Robinson D., Kung H. J. (2000): KFC, a Ste20-1ike kinase with mitogenic potential and capability to activate the SAPK/JNK pathway. Oncogene 19, 710-718
23. Zhao Y., Meng X. M., Wei Y. J., Zhao X. W., Liu D. Q., Cao H. Q., Liew C. C., Ding J. F. (2003): Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J. Mol. Med. 81, 297-304