In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3′ regulatory region induces MYC expression at the immature stage of B cell development

Genes Chromosomes and Cancer

Volumn 46, Issue 10, 2007, Pages 950-959

  Yan, Yi ^a   Sung, Sup Park ^b,c   Janz, Siegfried ^b,d   Eckhardt, Laurel A ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; BONE MARROW CELL; BURKITT LYMPHOMA; CELL COMPARTMENTALIZATION; CELL LINEAGE; CHROMOSOME TRANSLOCATION; DEVELOPMENTAL STAGE; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE LOCUS; GENE MUTATION; GENE TRANSLOCATION; GERMINAL CENTER; IMMUNOGLOBULIN HEAVY CHAIN GENE; INTRON; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSGENE; TRANSGENIC MOUSE;

3' UNTRANSLATED REGIONS; ANIMALS; B-LYMPHOCYTES; BLOTTING, SOUTHERN; BONE MARROW CELLS; BURKITT LYMPHOMA; CELLS, CULTURED; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; LIPOPOLYSACCHARIDES; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; REGULATORY SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLEEN; TRANSLOCATION, GENETIC;

MUS; MUS MUSCULUS;

EID: 34548784305     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20480     Document Type: Article

References (41)

1. Andersson T, Furebring C, Borrebaeck CAK, Pettersson S. 1999. Temporal expression of a VH promoter-Cmu transgene linked to the IgH HS1,2 enhancer. Mol Immunol 36:19-29.
2. Arulampalam V, Eckhardt L, Pettersson S. 1997. The enhancer shift: a model to explain the developmental control of IgH gene expression in B-lineage cells. Immunol Today 18:549-554.
3. Arulampalam V, Grant PA, Samuelsson A, Lendahl U, Pettersson S. 1994. Lipopolysaccharide-dependent transactivation of the temporally regulated immunoglobulin heavy chain 3′ enhancer. Eur J Immunol 24:1671-1677.
4. Avigan MI, Strober B, Levens D. 1990. A far upstream element stimulates c-myc expression in undifferentiated leukemia cells. J Biol Chem 265:18538-18545.
5. Bergsagel PL, Kuehl WM. 2001. Chromosome translocations in multiple myeloma. Oncogene 20:5611-5622.
6. Chauveau C, Jansson EA, Muller S, Cogne M, Pettersson S. 1999. Cutting Edge: Ig heavy chain 3′ HS1-4 directs correct spatial position-independent expression of a linked transgene to B lineage cells. J Immunol 163:4637-4641.
7. Chen C, Birshtein BK. 1997. Virtually identical enhancers containing a segment of homology to murine 3′IgH-E(hs1,2) lie downstream of human Ig Cα1 and Cα2 genes. J Immunol 159:1310-1318.
8. Chen J, Young F, Bottaro A, Stewart V, Smith RK, Alt FW. 1993. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J 12:4635-4645.
9. Cheung WC, Kim JS, Linden M, Peng L, Van Ness B, Polakiewicz RD, Janz S. 2004. Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest 113:1763-1773.
10. Chung HJ, Levens D. 2005. c-myc expression: Keep the noise down! Mol Cells 20:157-166.
11. Cogne M, Lansford R, Bottaro A, Zheng J, Gorman J, Young KF, Cheng HL, Alt FW. 1994. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell 77:737-747.
12. Dariavach P, Williams GT, Campbell K, Pettersson S, Neuberger MS. 1991. The mouse IgH 3′-enhancer. Eur J Immunol 21:1499-1504.
13. Dunnick WA, Shi J, Graves KA, Collins JT. 2005. The 3′ end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four γ genes. J Exp Med 201:1459-1466.
14. Facchini LM, Chen S, Marhin WW, Lear JN, Penn LZ. 1997. The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter. Mol Cell Biol 17:100-114.
15. Garrett FE, Emelyanov AV, Sepulveda MA, Flanagan P, Volpi S, Li F, Loukinov D, Eckhardt LA, Lobanenkov VV, Birshtein BK. 2005. Chromarin archirecture near a potential 3′ end of the igh locus involves modular regulation of histone modifications during B-cell development and in vivo occupancy at CTCF sites. Mol Cell Biol 25:1511-1525.
16. Grant PA, Andersson T, Neurath MF, Arulampalam V, Bauch A, Muller R, Reth M, Pettersson S. 1996. A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3′ enhancer. EMBO J 15:6691-6700.
17. Heckman CA, Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM. 2003. Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2. Cancer Res 63:6666-6673.
18. Kim MJ, Park BJ, Kang YS, Kim HJ, Park JH, Kang JW, Lee SW, Han JM, Lee HW, Kim S. 2003. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Nat Genet 34:330-336.
19. Kovalchuk AL, Qi CF, Torrey TA, Taddesse-Heath L, Feigenbaum L, Park SS, Gerbitz A, Klobeck G, Hoertnagel K, Polack A, Bornkamm GW, Janz S, Morse HC, III. 2000. Burkitt lymphoma in the mouse. J Exp Med 192:1183-1190.
20. Lieberson R, Giannini SL, Birshtein BK, Eckhardt LA. 1991. An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res 19:933-937.
21. Liu J, Levens D. 2006. Making myc. Curr Top Microbiol Immunol 302:1-32.
22. Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D. 2000. The FBP interacting repressor targets TFIIH to inhibit activated transcription. Mol Cell 5:331-341.
23. Manis JP, van der Stoep N, Tian M, Ferrini R, Davidson L, Bottaro A, Alt FW. 1998. Class switching in B cells lacking 3′ immunoglobulin heavy chain enhancers. J Exp Med 188:1421-1431.
24. Meulia T, Krumm A, Spencer C, Groudine M. 1992. Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter. Mol Cell Biol 12:4590-4600.
25. Mills KD, Ferguson DO, Alt FW. 2003. The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev 194:77-95.
26. Mills F Harindranath N, Mitchell M, Max E. 1997. Enhancer complexes located downstream of both human immunoglobulin C a genes. J Exp Med 186:845-858.
27. Morvan CL, Pinaud E, Decourt C, Cuvillier A, Cogne M. 2003. The immunoglobulin heavy-chain locus hs3b and hs4 3′ enhancers are dispensable for VDJ assembly and somatic hypermutation. Blood 102:1421-1427.
28. Ong J, Stevens S, Roeder RG, Eckhardt LA. 1998. 3′ IgH enhancer elements shift synergistic interactions during B cell development. J Immunol 160:4896-4903.
29. Perlot T, Alt FW, Bassing CH, Suh H, Pinaud E. 2005. Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci USA 102:14362-14367.
30. Pettersson S, Cook GP, Bruggemann M, Williams GT, Neuberger MS. 1990. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature 344:165-168.
31. Pinaud E, Khamlichi A, Le Morvan C, Drouet M, Nalesso V, Le Bert M, Cogne M. 2001. Localization of the 3′IgH locus elements that effect long-distance regulation of class switch recombination. Immunity 15:187-199.
32. Podojil JR, Sanders VM. 2003. Selective regulation of mature IgG1 transcription by CD86 and β2-adrenergic receptor stimulation. J Immunol 170:5143-5151.
33. Polack A, Strobl L, Feederle R, Schweizer M, Koch E, Eick D, Wicgand H, Bornkamm GW. 1991. The intron enhancer of the immunoglobulin K gene activates c-myc but does not induce the Burkitt-specific promoter shift. Oncogene 6:2033-2040.
34. Polack A, Feederle R, Klobeck G, Hortnagel K. 1993. Regulatory elements in the immunoglobulin K locus induce c-myc activation and the promoter shift in Burkitt's lymphoma cells. EMBO J 12:3913-3920.
35. Ronai D, Iglesias-Ussel MD, Fan M, Shulman MJ, Scharff MD. 2005. Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells. Proc Natl Acad Sci USA 102:11829-11834.
36. Seidl KJ, Manis JP, Bottaro A, Zhang J, Davidson L, Kisselgof A, Oettgen H, Alt FW. 1999. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proc Natl Acad Sci USA 96:3000-3005.
37. Serwe M, Sablitzky F. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J 12:2321-2327.
38. Shi X, Eckhardt LA. 2001. Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3′enhancer pair in an Ig-secreting but not an earlier-stage B cell line. Int Immunol 13:1003-1012.
39. Stevens S, Ong J, Kim U, Eckhardt LA, Roeder RG. 2000. Role of OCA-B in 3′-IgH enhancer function. J Immunol 164:5306-5312.
40. Terauchi A, Hayashi K, Kitamura D, Kozono Y, Motoyama N, Azuma T 2001. A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hvpermutation of IgH genes. J Immunol 167:811-820.
41. Wang J, Boxer L. 2005. Regulatory elements in the immunoglobulin heavy chain gene 3′-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells. J Biol Chem 280:12766-12773.