Efficacy and safety of atomoxetine in adolescents with attention-deficit/ hyperactivity disorder and major depression

Journal of Child and Adolescent Psychopharmacology

Volumn 17, Issue 4, 2007, Pages 407-419

  Bangs, Mark E ^a   Emslie, Graham J ^b   Spencer, Thomas J ^c   Ramsey, Janet L ^a   Carlson, Christopher ^a   Bartky, Eric J ^d   Busner, Joan ^e,f   Duesenberg, David A ^g   Harshawat, Paras ^h   Kaplan, Stuart L ^e,i   Quintana, Humberto ^j   Allen, Albert J ^a   Sumner, Calvin R ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MORRISTOWN MEMORIAL HOSPITAL   (United States)

^e PENN STATE COLLEGE OF MEDICINE   (United States)

^f PharmaStar   (United States)

^g Mercy Health Research   (United States)

^h Clinco   (United States)

ⁱ Devereux Foundation   (United States)

^j LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ATOMOXETINE; PLACEBO;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ANOREXIA; ARTICLE; ATTENTION DEFICIT DISORDER; ATTENTION DEFICIT HYPERACTIVITY DISORDER RATING SCALE; CLINICAL ASSESSMENT; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; FATIGUE; FEMALE; FEVER; HEADACHE; HUMAN; INFLUENZA; IRRITABILITY; KIDIE SCHEDULE FOR AFFECTIVE DISORDERS AND SCHIZOPHRENIA FOR SCHOOL AGE CHILDREN PRESENT AND LIFETIME VERSION; LETHARGY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MANIA; NAUSEA; NEUROPSYCHOLOGICAL TEST; OPEN STUDY; OUTCOME ASSESSMENT; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; SIDE EFFECT; SOMNOLENCE; STANDARD; STATISTICAL SIGNIFICANCE; SUICIDAL BEHAVIOR; SUICIDAL IDEATION; TREATMENT DURATION; VOMITING; WEIGHT GAIN; WEIGHT REDUCTION;

ADOLESCENT; ADRENERGIC UPTAKE INHIBITORS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIPOLAR DISORDER; CHILD; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; NAUSEA; PROPYLAMINES; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX;

EID: 34548780191     PISSN: 10445463     EISSN: None     Source Type: Journal    
DOI: 10.1089/cap.2007.0066     Document Type: Article

References (36)

1. Alessi NE, Magen, J: Comorbidity of other psychiatric disturbances in depressed psychiatrically hospitalized children. Am J Psychiatry 145:1582-1584, 1988.
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Washington, DC: American Psychiatric Press, 1994.
3. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-IV-TR). Washington, DC, American Psychiatric Press, 2000.
4. Anderson JC, Williams S, McGee R, Silva PA: DSM-III disorders in preadolescent children: Prevalence in a large sample from the general population. Arch Gen Psychiatry 44:69-76, 1987.
5. Bangs ME, Tauscher-Wisniewski S, Polzer J, Zhang S, Acharya N, Desaiah D, Allen AJ: Meta-analysis of suicide-related events in atomoxetine-treated patients. Scientific Proceedings of the 52nd Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Toronto, Ont., October 18-23, 2005, p. 132, abstract B49.
6. Biederman J, Newcorn J, Sprich S: Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry 148564-577, 1991.
7. Biederman J, Faraone S, Milberger S, Curtis S, Chen L, Marrs A, Ouellette C, Moore P, Spencer T: Predictors of persistence and remission of ADHD into adolescence: Results from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry 35:343-351, 1996.
8. Biederman J, Heiligenstein JH, Faries DE, Galil N, Dittmann R, Emslie GJ, Kratochvil CJ, Laws HF, Schuh KJ: Atomoxetine ADHD Study Group: Efficacy of atomoxetine versus placebo in school-age girls with attention-deficit/ hyperactivity disorder. Pediatrics 110:e75, 2002.
9. Bird HR, Canino G, Rubio-Stipec M, Gould MS, Ribera J, Sesman M, Woodbury M, Huertas-Goldman S, Pagan A, Sanchez-Lacay A, Moscoso M: Estimates of the prevalence of childhood maladjustment in a community survey in Puerto Rico. The use of combined measures. Arch Gen Psychiatry 45:1120-1126, 1988. Erratum in: Arch Gen Psychiatry 51:429, 1994.
10. Birmaher B, McCafferty JP, Bellew KM, Beebe KL: Disruptive disorders as predictors of response in adolescents with depression. Scientific Proceedings of the 48th Annual Meeting of the American Academy of Child and Adolescent Psychiatry; Honolulu, HI,, October 23-28, 2001, p. 37, abstract 1B.
11. Brent DA, Perper JA, Moritz G, Allman C, Friend A, Roth C, Schweers J, Balach L, Baugher M: Psychiatric risk factors for adolescent suicide: A case-control study. J Am Acad Child Adolesc Psychiatry 32521-529, 1993.
12. DuPaul GJ, Power TJ, Anastopoulos AD, Reid R: ADHD Rating Scale-IV: Checklists, Norms, and Clinical Interpretation. New York, The Guilford Press, 1998.
13. Faraone SV, Sergeant J, Gillberg C, Biederman J: The worldwide prevalence of ADHD: Is it an American condition? World Psychiatry 2:104-113, 2003.
14. Gadow KD, Nolan EE, Litcher L, Carlson GA, Panina N, Golovakha E, Sprafkin J, Bromet EJ: Comparison of attention-deficit/hyperactivity disorder symptom subtypes in Ukrainian schoolchildren. J Am Acad Child Adolesc Psychiatry 39:1520-1527, 2000.
15. Geller B, Fox LW, Clark KA: Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children. J Am Acad Child Adolesc Psychiatry 33:461-468, 1994.
16. Gomez R, Harvey J, Quick C, Scharer I, Harris G: DSM-IV AD/HD: Confirmatory factor models, prevalence, and gender and age differences based on parent and teacher ratings of Australian primary school children. J Child Psychol Psychiatry 40:265-274, 1999.
17. Guy W: ECDEU Assessment Manual for Psychopharmacology, Revised. Publication ADM 76-338. Rockville, Maryland), U.S. Department of Health, Education, and Welfare, 1976.
18. Henderson TA: Mania induction associated with atomoxetine. J Clin Psychopharmacol 24567-568, 2004.
19. James A, Lai FH, Dahl C: Attention deficit hyperactivity disorder and suicide: A review of possible associations. Acta Psychiatr Scand 110:408-415, 2004.
20. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N: Schedule for Affective Disorders and Schizophrenia for School-age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980-988, 1997.
21. Kelsey DK, Sumner CR, Casat CD, Coury DL, Quintana H, Saylor KE, Sutton VK, Gonzales J, Malcolm SK, Schuh KJ, Allen AJ: Once-daily atomoxetine treatment for children with attention-deficit/hyperactivity disorder, including an assessment of evening and morning behavior: A double-blind, placebo-controlled trial. Pediatrics 114:e1-e8, 2004.
22. Kratochvil CJ, Heiligenstein JH, Dittmann R, Spencer TJ, Biederman J, Wernicke J, Newcorn JH. Casat C, Milton D, Michelson D: Atomoxetine and methylphenidate treatment in children with ADHD: A prospective, randomized, open-label trial. J Am Acad Child Adolesc Psychiatry 41:776-784, 2002.
23. Michelson D, Faries D, Wernicke J, Kelsey D, Kendrick K, Sallee FR, Spencer T, Atomoxetine ADHD Study Group: Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: A randomized, placebo-controlled, dose-response study. Pediatrics 108:e83, 2001.
24. Michelson D, Allen AJ, Busner J, Casat C, Dunn D, Kratochvil C, Newcorn J, Sallee FR, Sangal RB, Saylor K, West S, Kelsey D, Wernicke J, Trapp NJ, Harder D: Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: A randomized, placebo-controlled study. Am J Psychiatry 159:1896-1901, 2002.
25. Montgomery SA, Åsberg M: A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382-389, 1979.
26. Poznanski E, Mokros HB: Children's Depression Rating Scale, Revised. Los Angeles (California), Western Psychological Services, 1999.
27. Renaud J, Brent DA, Birmaher B, Chiappetta L, Bridge J: Suicide in adolescents with disruptive disorders. J Am Acad Child Adolesc Psychiatry 38:846-851, 1999.
28. Spencer T, Heiligenstein JH, Biederman J, Faries DE, Kratochvil CJ, Conners CK, Potter WZ: Results from 2 proof-of-concept, placebo-controlled studies of atomoxetine in children with attention-deficit/hyperactivity disorder. J Clin Psychiatry 63:1140-1147, 2002.
29. Spencer TJ, Kratochvil CJ, Sangal RB, Saylor KE, Bailey CE, Dunn DW, Geller DA, Casat CD, Lipetz RS, Jain R, Newcorn JH, Ruff DD, Feldman PD, Furr AJ, Allen AJ: Effects of atomoxetine on growth in children with ADHD following up to five years of treatment. J Child Adolesc Psychopharmacol, in press.
30. Steinberg S, Chouinard G: A case of mania associated with tomoxetine. Am J Psychiatry 142:1517-1518, 1985.
31. Strober M, Schmidt-Lackner S, Freeman R, Bower S, Lampert C, DeAntonio M: Recovery and relapse in adolescents with bipolar affective illness: A five-year naturalistic, prospective follow-up. J Am Acad Child Adolesc Psychiatry 34:724-731, 1995.
32. Swensen AR, Kruesi MJP, Allen AJ, Buesching D, Secnik K: Self-injury and suicide in patients with attention-deficit/hyperactivity disorder. Scientific Proceedings of the 49th Annual Meeting of the American Academy of Child and Adolescent Psychiatry, San Francisco, California, October 22-27, 2002, p. 136, abstract F27.
33. Voeller KK: Attention-deficit hyperactivity disorder (ADHD). J Child Neurol 19:798-814, 2004.
34. Weiss M, Tannock R, Kratochvil C, Dunn D, Velez-Borras J, Thomason C, Tamura R, Kelsey D, Stevens L, Allen AJ: A randomized, placebo-controlled study of once-daily atomoxetine in the school setting in children with ADHD. J Am Acad Child Adolesc Psychiatry 44:647-655, 2005.
35. Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E: Selective serotonin reuptake inhibitors in childhood depression: Systematic review of published versus unpublished data. Lancet 363:1341-1345, 2004.
36. Young RC, Biggs JT, Ziegler VE, Meyer DA: A rating scale for mania: Reliability, validity and sensitivity. Br J Psychiatry 133:429-435, 1978.