How to interpret and appropriately appreciate the antinuclear antibody test;Como interpretar e valorizar adequadamente o teste de anticorpos antinúcleo

Jornal Brasileiro de Patologia e Medicina Laboratorial

Volumn 43, Issue 3, 2007, Pages 157-168

  Dellavance, Alessandra ^a   Andrade, Luís Eduardo Coelho ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b Fleury   (Brazil)

Author keywords

Antinuclear antibodies; Autoantibodies; Autoimmune diseases; HEp 2 cells; Serological markers

Indexed keywords

EID: 34548776913     PISSN: 16762444     EISSN: 16784774     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. AARDEN, L.A. et al. Detection of antibodies to DNA by radioimmunoassay and immunofluorescence. Scand J Rheumatol, Suppl 11, p. 12-9, 1975.
2. ANDERSON, J.R. et al. Precipitating antibodies in the connective tissue diseases. Ann Rheum Dis, v. 21, p. 360-9, 1962.
3. ANDRADE, L.E. et al. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80 coilin. J Exp Med, v. 173, p. 1407-19, 1991.
4. ANDRADE, L.E.C. Como valorizar os resultados de teste de FAN (anticorpos antinúcleo) e suas diferentes metodologias. Sinopses em Reumatologia, v. 4, p. 3-9, 2002.
5. ARBUCKLE, M.R. et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med, v. 349, p. 1526-33, 2003.
6. BENITO-GARCIA, E. et al. The American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines. Guidelines for Immunologic Laboratory Testing in the Rheumatic Diseases: anti-Sm and anti-RNP antibody tests. Arthritis Rheum, v. 51, p. 1030-44, 2004.
7. BEYNE-RAUZY, O. et al. Anti-PCNA antibodies: prevalence and predictive value. Joint Bone Spine, v. 72, n. 5, p. 432-5, 2005.
8. CIMOLAI, N.; MAH, D.; ROLAND, E. Anticentriolar autoantibodies in children with central nervous system manifestations of Mycoplasma pneumoniae infection. J Neurol Neurosurg Psychiatry, v. 57, n.5, p. 638-9, 1994.
9. COONS, A.H.; KAPLAN, M.H. Localization of antigen in tissue cells: II. Improvements in a method for the detection of antigen by means of fluorescent antibody. J Exp Med, v. 91, p. 1-13, 1950.
10. COOPER, G.M. Estrutura e função celular - domínios funcionais dentro do núcleo. In: COOPER, G.M., editor. A Célula - uma abordagem molecular. 2 ed. Porto Alegre: Artmed Editora, 2002. p. 712:356.
11. DEANE, P.M.G. et al. The outcome of children referred to a pediatric rheumatology clinic with a positive antinuclear antibody test but without an autoimmune disease. Pediatrics, v. 95, p. 892, 1995.
12. DELLAVANCE, A. et al. II Consenso Brasileiro de Fator Antinuclear em Células HEp-2. Definições para padronização da pesquisa contra constituintes do núcleo, nucléolo, citoplasma e aparelho mitótico e suas associações clínicas. Rev Bras Reum, v. 43, p. 129-40, 2003.
13. DELLAVANCE, A. et al. The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern. J Rheumatol, v. 32, n. 11, p. 2144-9, 2005.
14. FATHI, M. et al. Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis. Ann Rheum Dis, v. 63, p. 297-301, 2004.
15. FERNANDEZ, S.A.V. et al. Prevalence of antinuclear autoantibodies in the serum of normal blood donors. Rev Hosp Clin Fac Med S. Paulo, v. 58, p. 315-9, 2003.
16. FORSLID, J. et al. The prevalence of antinuclear antibodies in healthy young persons and adults, comparing rat liver tissue sections with HEp-2 cells as antigen substrate. Clin Exp Rheumatol, v. 12, p. 137-41, 1994.
17. FRITZLER, M.J. et al. Antinuclear, anticytoplasmic, and anti-Sjögren's syndrome antigen A (SS-A/Ro) antibodies in female blood donors. Clin Immunol Immunopathol, v. 36, p. 120-8, 1985.
18. GONZALES, C. et al. Anti-nucleosome, anti-chromatin, anti-dsDNA and anti-histone antibody reactivity in systemic lupus erythematosus. Clin Chem Lab Med, v. 42, p. 266-72, 2004
19. GOTO, N. et al. Anti-p80 coilin autoantibodies react with a conserved epitope and are associated with anti-DSF70/LEDGF autoantibodies. J Autoimmun, v. 26, n. 1, p. 42-51. 2006
20. HARGRAVES, M.; RICHMOND, M.; MORTON, R. Presentation of two bone marrow elements: the "tart" cell or LE cell. Mayo Clin Proc, v. 23, p. 25-8, 1948.
21. HARMON, C.E.; DENG, J-S.; PEEBLES, C.L. The importance of tissue substrate in the SS-A/Ro antigen-antibody system. Arthritis Rheum, v. 27, p. 166-73, 1984.
22. HILARIO, M.O. et al. Frequency of antinuclear antibodies in healthy children and adolescents. Clin Pediatr, v. 43, p. 637-42, 2004.
23. HO, K.T.; REVEILLE, J.D. The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther, v. 5, p. 80-93, 2003.
24. HOCHBERG, M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus [letter]. Arthritis Rheum, v. 40, p. 1725, 1997.
25. INOKUCHI, T. et al. Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings. Magn Reson Imaging, v. 24, p. 1389-93, 2006.
26. LACROIX-DESMAZES, S. et al. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J Immunol Methods, v. 216, p. 117-37, 1998.
27. LAURINO, C.F.C. et al. Human autoantibodies to diacylphosphatidylethanolamine recognize a specific set of discrete cytoplasmic domains. Clin Exp Immunol, v. 143, n. 572-84, 2006.
28. LESER, P.G. et al. Distinctive features of antinuclear antibodies observed in health and in subjects with autoimmune rheumatic diseases. In: CONRAD, K. et al. (org.). From animal models to human genetics: research on the induction and pathogenicity of autoantibodies. Dresden: Pabst Science Publishers, 2004. p. 493-510.
29. MASSABKI, P.S. et al. Clinical implications of autoantibodies in HIV infection. AIDS, v. 11, p. 1845-50, 1997.
30. MIGLIORINI, P. et al. Anti-Sm and anti-RNP antibodies. Autoimmunity, v. 38, p. 47-54, 2005.
31. REIMER, G. et al. Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma). Arthritis Rheum, v. 31, p. 525-32, 1988.
32. ROKEACH, I.A.; HOCH, S.O. B-cell epitopes of Sm autoantigens. Mol Biol Reports, v. 16, p. 165-74, 1992.
33. SANTOS, L.M. et al. Prevalência e valor prognóstico de anticorpos antinucleares em indivíduos idosos. Rev Bras Reumatol, v. 37, p. 323-8, 1997.
34. SHINOHARA, T.; SINGH, D.P.; FATMA, N. LEDGF, a survival factor, activates stress-related genes. Prog Retin Eye Res, v. 21, p. 341-58, 2002.
35. SILVA, N.P. et al. Desenvolvimento de ensaio imunoenzimá tico (ELISA) para detecção de anticorpos anti-DNA nativo usando DNA de Crithidia luciliae como substrato. Rev Bras Reumatol, v. 35, p. 183-8, 1995.
36. SZANTO, A. et al. Clinical, serologic, and genetic profiles of patients with associated Sjogren's syndrome and systemic lupus erythematosus. Hum Immunol, v. 67, n. 11, p. 924-30, 2006.
37. TAKASAKI, Y. Anti-PCNA antibody. Nippon Rinsho, v. 57, Suppl, p. 456-8, 1999.
38. TAN, E.M. et al. Range of antinuclear antibodies in "healthy" individuals. Arthritis Rheum, v. 40, n. 9, p. 1601-11, 1997.
39. TAN, E.M. et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum, v. 25, p. 1271-7, 1982.
40. VAILE, J.H. et al. Is high titer ANA specific for connective tissue disease? Clin Exp Rheumatol, v. 18, p. 433, 2000.
41. WATANABE, A. et al. Anti-DFS70 antibodies in 597 healthy hospital workers. Arthritis Rheum, v. 50, p. 892-900, 2004.