Does current knowledge explain the pathogenesis of idiopathic pulmonary fibrosis? A perspective

Proceedings of the American Thoracic Society

Volumn 4, Issue 5, 2007, Pages 449-452

  Hunninghake, Gary W ^a   Schwarz, Marvin I ^b  

^a UNIVERSITY OF IOWA   (United States)

^b NONE

Author keywords

Fibrosis; Injury; Repair

Indexed keywords

COLLAGEN; MATRIX PROTEIN; SURFACTANT PROTEIN C; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC PNEUMONITIS; CELL PROLIFERATION; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; EMPHYSEMA; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE MUTATION; GENETICS; HISTOPATHOLOGY; HUMAN; INFLAMMATION; INTERSTITIAL PNEUMONIA; LUNG FIBROSIS; LUNG FUNCTION; LUNG INJURY; LUNG PARENCHYMA; MORTALITY; PATHOGENESIS; PULMONARY HYPERTENSION; SMOKING; SYMPTOM;

CAUSALITY; DISEASE PROGRESSION; EPITHELIAL CELLS; HUMANS; INFLAMMATION; LUNG; PULMONARY FIBROSIS;

EID: 34548771370     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200702-036MS     Document Type: Conference Paper

References (50)

1. Chua F, Gauldie J, Laurent GJ. Pulmonary fibrosis: searching for model answers. Am J Respir Cell Mol Biol 2005;33:9-13.
2. Antoniades HN, Bravo MA, Avila RE, Galanopoulos T, Neville-Golden J, Maxwell M, Selman M. Platelet-derived growth factor in idiopathic pulmonary fibrosis. J Clin Invest 1990;86:1055-1064.
3. Kapanci Y, Desmouliere A, Pache JC, Redard M, Gabbiani G. Cytoskeletal protein modification in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis: possible role of transforming growth factor β and tumor necrosis factor α. Am J Respir Crit Care Med 1995;152:2163-2169.
4. Pan LH, Yamauchi K, Uzuki M, Nakanishi T, Takigawa M, Inoue H, Sawai T. Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factors in IPF. Eur Respir J 2001;17:1220-1227.
5. Wallace SH, Howie SE. Immunoreactive interleukin 4 and interferon-gamma expression by alveolar type II cells in interstitial lung disease. J Pathol 1999;187:475-480.
6. Pardo A, Selman M. Idiopathic pulmonary fibrosis: new insights in its pathogenesis. Int J Biochem Cell Biol 2002;34:1534-1538.
7. Pardo A, Selman M. Molecular mechanisms of pulmonary fibrosis. Front Biosci 2002;7:d1743-d1761.
8. Nogee LM, Dunbar AE III, Wert SE, Askin F, Hamas A, Whitsett JA. A mutation in the surfactant C protein associated with familial interstitial lung disease. N Engl J Med 2001;344:573-579.
9. Thomas AO, Lane K, Phillips J III, Markin PM, Speer M, Schwartz DA, Gaddipati R, Marvnev A, Johnson J, Roberts R, et al. Heterozygosity for a surfactant protein C mutation associated with usual interstitial pneumonia and cellular non-specific interstitial pneumonia in one kindred. Am J Respir Crit Care Med 2002;165:1322-1328.
10. Xaubet A, Marin-Arguedas A, Lario S, Ancochea J, Morell F, Ruiz-Manzano J, Rodriguez-Becerra E, Rodriguez-Arias JM, Inigo P, Sanz S, et al. Transforming growth factor-β1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003;168:431-435.
11. Khalil N, O'Conner RN, Unruh HW, Warren PW, Flanders KC, Kemp A, Bereznay OH, Greenberg AH. Increased production and immunohistochemical localization of transforming growth factor-β in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 1991;5:155-162.
12. Keane MP, Streiter RM, Belperio JA. Mechanisms and mediators of pulmonary fibrosis. Immunology 2005;25:429-463.
13. Sheppard D. Transforming growth factor β: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 2006;3:413-417.
14. American Thoracic Society; European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. Am J Respir Crit Care Med 2000;161:646-664.
15. American Thoracic Society; European Respiratory Society. Idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2002;165:277-304.
16. Battista G, Zompatori M, Fasano L, Pacilli A, Basile B. Progressive worsening of idiopathic pulmonary fibrosis: high resolution computed tomography (HRCT) study with functional correlations. Radiol Med (Torino) 2003;105:2-11.
17. Kuhn C, McDonald JA. The roles of the myofibroblast in idiopathic pulmonary fibrosis: ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis. Am J Pathol 1991;138:1257-1265.
18. King TE Jr, Schwarz MI, Brown K, Tooze JA, Colby TV, Waldron JA, Flint A, Thurlbeck W, Cherniack RM. Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med 2001;164:1025-1032.
19. Nicholson AG, Fulford LG, Colby TV, du Bois RM, Wells AU. The relationship between individual histologic features and disease in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2002;166:173-177.
20. Katzenstein AL, Meyers JL. Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med 1998;157:1301-1315.
21. Cool CD, Groshong SD, Rai PR, Henson PM, Stewart JS, Brown KK. Fibroblast foci are not discrete sites of lung injury or repair. Am J Respir Crit Care Med 2006;174:654-658.
22. King TE Jr, Tooze JA, Schwarz MI, Brown KR, Cherniack RM. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med 2001;164:1171-1181.
23. King TE Jr. Clinical advances in the diagnosis and therapy of the interstitial lung diseases. Am J Respir Crit Care Med 2005;172:268-279.
24. Kondoh Y, Taniguchi H, Kawbata Y, Yokoi T, Suzuki K, Takagi K. Acute exacerbation in idiopathic pulmonary fibrosis: analysis of clinical and pathologic findings in three cases. Chest 1993;103:1808-1812.
25. Ambrosini V, Cancellieri A, Chilosi M, Zampatori M, Trisolini R, Saragoni L, Poletti V. Acute exacerbations of idiopathic pulmonary fibrosis: report of a series. Eur Respir J 2003;22:821-826.
26. Kim DS, Park JH, Park BK, Lee JS, Nicholson AG, Colby T. Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features. Eur Respir J 2006;27:143-150.
27. Parambil JG, Myers JL, Ryu JH. Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy. Chest 2005;128:1475-1482.
28. Flaherty KR, Travis WD, Colby TV, Toews GB, Kazerooni EA, Gross BH, Jain A, Strawderman RL, Flint A, Lynch JP, et al. Histopathologic variability in usual and nonspecific interstitial pneumonias. Am J Respir Crit Care Med 2001;164:1722-1727.
29. Martinez FJ. Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia. Proc Am Thorac Soc 2006;3:81-95.
30. Renzoni EA, Walsh DA, Salmon M, Wells AU, Sestini P, Nicholson AG, Veeraraghavan S, Bishop AE, Romanska HM, Pantelidis P, et al. Interstitial vascularity in fibrosing alveolitis. Am J Respir Crit Care Med 2003;167:438-443.
31. Turner-Warwick M. Precapillary systemic-pulmonary anastomoses. Thorax 1963;18:225-237.
32. Keane MP, Arenberg DA, Lynch JP, Whyte RI, Iannettoni MD, Burdick MD, Wilke CA, Morris SB, Glass MC, DiGiovine B, et al. The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 1997;159:1437-1443.
33. Keane MP, Belperio JA, Arenberg DA, Burdick MD, Xu ZJ, Xue YY, Strieter RM. IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. J Immunol 1999;163:5686-5692.
34. Cosgrove GP, Brown KK, Scheimann WP, Serls A, Parr J, Geraci MW, Schwarz MI, Cool CD, Worthen GS. Pigment epithelium-derived growth factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis. Am J Respir Crit Care Med 2004;110:242-251.
35. Lettieri CJ, Nathan SD, Barnett SD, Ahmad S, Shorr AF. Prevalence and outcomes of pulmonary arterial hypertension in advanced lung disease. Chest 2006;129:746-752.
36. Nadrous HF, Pellikka PA, Krowka MJ, Swanson KL, Chaowalit N, Decker PA, Ryu JH. The impact of pulmonary hypertension on survival in patients with idiopathic pulmonary fibrosis. Chest 2005;128(6 Suppl):616S-617S.
37. Kubo H, Nakayama K, Yanai M, Suzuki T, Yamaya M, Watanabe M, Sasaki H. Anticoagulant therapy for idiopathic pulmonary fibrosis. Chest 2005;128:1475-1482.
38. Uhal BD, Joshi I, True AL, Mundle S, Raza A, Pardo A, Selman M. Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro. Am J Physiol 1995;269:L819-L828.
39. Selman M, King TE Jr, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypothesis about its pathogenesis. Ann Intern Med 2001;134:136-151.
40. Selman M, King TE, Pardo A; American Thoracic Society; European Respiratory Society; American College of Chest Physicians. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc 2006;3:364-372.
41. Marchand-Adam S, Fabre A, Mailleux AA, Marchal J, Quesnel C, Kataoka H, Aubier M, Dehoux M, Soler P, Crestani B. Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174:58-66.
42. Baumgartner KB, Samet JM, Stidly CA, Colby TV, Waldron JA. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1997;155:242-248.
43. Steele MP, Speer MC, Loyd JE, Brown KK, Herron A, Slifer SH, Burch LH, Wahidi MM, Phillips JA, Sporn TA, et al. The clinical and pathologic features of familial interstitial pneumonia. Am J Respir Crit Care Med 2005;172:1146-1152.
44. Selman M. The spectrum of smoking-related interstitial lung disorders: the never-ending story of smoke and disease. Chest 2006;124:1185-1186.
45. Myers JL, Veal CF Jr, Shin MS, Katzenstein AL. Respiratory bronchiolitis causing interstitial lung disease: a clinicopathologic study of six cases. Am Rev Respir Dis 1987;135:880-884.
46. Fraig M, Shreesha U, Savici D, Katzenstein AL. Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokers. Am J Surg Pathol 2002;26:647-653.
47. Yang IV, Burch LH, Steele MP, Savov JD, Hollingsworth JW, McElvania-Tekippe E, Berman KG, Speer MC, Sporn TA, Brown KK, et al. Gene expression profiling of familial and sporadic interstitial pneumonia. Am J Respir Crit Care Med 2007;175:45-54.
48. Vourlekis JS, Schwarz MI, Cherniack RM, Curran-Everett D, Cool CD, Tuder RM, King TE, Brown KK. The effect of pulmonary fibrosis on survival in patients with hypersensitivity pneumonitis. Am J Med 2004;116:662-668.
49. Cottin V. Interstitial lung disease: are we missing formes frustes of connective tissue disease? Eur Respir J 2006;28:893-896.
50. Raghu G. The role of gastroesophageal reflux in idiopathic pulmonary fibrosis. Am J Med 2003;115(Suppl 3A):60S-64S.