Polymorphisms in apolipoprotein B and Risk of ischemic stroke

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 9, 2007, Pages 3611-3617

  Benn, Marianne ^a,b   Nordestgaard, Børge G ^b,c   Jensen, Jan Skov ^b,c   Tybjærg Hansen, Anne ^a,c  

^a Rigshospitalet   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENOTYPE; HAZARD RATIO; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN POLYMORPHISM; RISK REDUCTION;

EID: 34548765667     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-0221     Document Type: Article

References (29)

1. Walldius G, Aastveit AH, Jungner I 2006 Stroke mortality and the apoB/apoA-I ratio: results of the AMORIS prospective study. J Intern Med 259:259-266
2. Benn M, Nordestgaard BG, Jensen GB, Tybjærg-Hansen A 2007 Improving prediction of ischemic cardiovascular disease in the general population using apolipoprotein B. The Copenhagen City Heart Study. Arterioscler Thromb Vasc Biol 27:661-670
3. Humphries S 1988 DNA polymorphisms of the apolipoprotein genes - their use in the investigation of the genetic component of hyperlipidaemia and atherosclerosis. Atherosclerosis 72:89-108
4. Humphries SE, Dunning A, Xu CF, Peacock R, Talmud P, Hamsten A 1992 DNA polymorphism studies. Approaches to elucidating multifactorial ischemic-heart-disease: the Apo-B gene as an example. Ann Med 24:349-356
5. Bentzen J, Jorgensen T, Fenger M 2002 The effect of six polymorphisms in the apolipoprotein B gene on parameters of lipid metabolism in a Danish population. Clin Genet 61:126-134
6. Berg K, Hames C, Dahlen G, Frick MH, Krishan I 1976 Genetic lipoprotein variation and lipid levels in man. Clin Genet 10:97-103
7. Mann CJ, Anderson TA, Read J, Chester SA, Harrison GB, Kochl S, Ritchie PJ, Bradbury P, Hussain FS, Amey J, Vanloo B, Rosseneu M, Infante R, Hancock JM, Levitt DG, Banaszak LJ, Scott J, Shoulders CC 1999 The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins. J Mol Biol 285:391-408
8. Bradbury P, Mann CJ, Kochl S, Anderson TA, Chester SA, Hancock JM, Ritchie PJ, Amey J, Harrison GB, Levitt DG, Banaszak LJ, Scott J, Shoulders CC 1999 A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase. J Biol Chem 274:3159-3164
9. Segrest JP, Jones MK, De Loof H, Dashti N 2001 Structure of apolipoprotein B-100 in low density lipoproteins. J Lipid Res 42:1346-1367
10. Borén J, Lee I, Zhu W, Arnold K, Taylor S, Innerarity TL 1998 Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100. J Clin Invest 101:1084-1093
11. Chatterton JE, Phillips ML, Curtiss LK, Milne R, Fruchart JC, Schumaker VN 1995 Immunoelectron microscopy of low-density lipoproteins yields a ribbon and bow model for the conformation of apolipoprotein-B on the lipoprotein surface. J Lipid Res 36:2027-2037
12. Benn M, Nordestgaard BG, Jensen JS, Nilausen K, Meinertz H, Tybjærg-Hansen A 2005 Mutation in apolipoprotein B associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor. J Biol Chem 280:21052-21060
13. Frikke-Schmidt R, Tybjærg-Hansen A, Steffensen R, Jensen G, Nordestgaard BG 2000 Apolipoprotein E genotype: ε32 women are protected while ε43 and epsilon44 men are susceptible to ischemic heart disease: the Copenhagen City Heart Study. J Am Coll Cardiol 35:1192-1199
14. Tybjærg-Hansen A, Jensen HK, Benn M, Steffensen R, Jensen G, Nordestgaard BG 2005 Phenotype of heterozygotes for low-density lipoprotein receptor mutations identified in different background populations. Arterioscler Thromb Vasc Biol 25:211-215
15. Kornerup K, Nordestgaard BG, Feldt-Rasmussen B, Borch-Johnsen K, Jensen KS, Jensen JS 2002 Transvascular low-density lipoprotein transport in patients with diabetes mellitus (type 2) - a noninvasive in vivo isotope technique. Arterioscler Thromb Vasc Biol 22:1168-1174
16. Bilheimer DW, Eisenberg S, Levy RI 1972 The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations. Biochim Biophys Acta 260:212-221
17. Benn M, Nordestgaard BG, Jensen JS, Grande P, Sillesen H, Tybjærg-Hansen A 2005 Polymorphism in APOB associated with increased low-density lipoprotein levels in both genders in the general population. J Clin Endocrinol Metab 90:5797-5803
18. SAAM Institute 2002 SAAM II. 1992-2000 ed. Seattle: SAAM Institute, University of Washington
19. Cholesterol, diastolic blood pressure, and stroke 1995 13,000 strokes in 450,000 people in 45 prospective cohorts. Prospective studies collaboration. Lancet 346:1647-1653
20. Shahar E, Chambless LE, Rosamond WD, Boland LL, Ballantyne CM, McGovern PG, Sharrett AR 2003 Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. Stroke 34:623-631
21. MRC/BHF 2002 Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360:7-22
22. Amarenco P, Bogousslavsky J, Callahan III A, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, Zivin JA 2006 High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 355:549-559
23. Korhonen T, Savolainen MJ, Kesaniemi YA 1999 Variation of apolipoprotein B as a possible cause of decreased low density lipoprotein clearance and hypercholesterolemia. Atherosclerosis 146:1-10
24. Demant T, Houlston RS, Caslake MJ, Series JJ, Shepherd J, Packard CJ, Humphries SE 1988 Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene. J Clin Invest 82:797-802
25. Soria LF, Ludwig EH, Clarke HRG, Vega GL, Grundy SM, McCarthy BJ 1989 Association between a specific apolipoprotein-B mutation and familial defective apolipoprotein-B-100. Proc Nat Acad Sci USA 86:587-591
26. Ludwig EH, Hopkins PN, Allen A, Wu LL, Williams RR, Anderson JL, Ward RH, Lalouel JM, Innerarity TL 1997 Association of genetic variations in apolipoprotein B with hypercholesterolemia, coronary artery disease, and receptor binding of low density lipoproteins. J Lipid Res 38:1361-1373
27. Parhofer KG, Barrett PHR, Bier DM, Schonfeld G 1992 Lipoproteins containing the truncated apolipoprotein, Apo B-89, are cleared from human plasma more rapidly than Apo B-100 containing lipoproteins in vivo. J Clin Invest 89:1931-1937
28. Gabelli C, Bilato C, Martini S, Tennyson GE, Zech LA, Corsini A, Albanese M, Brewer Jr HB, Crepaldi G, Baggio G 1996 Homozygous familial hypobetalipoproteinemia. Increased LDL catabolism in hypobetalipoproteinemia due to a truncated apolipoprotein B species, apo B-87Padova. Arterioscler Thromb Vasc Biol 16:1189-1196
29. Linton MF, Farese Jr RV, Young SG 1993 Familial hypobetalipoproteinemia. J Lipid Res 34:521-541