Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands

Biopharmaceutics and Drug Disposition

Volumn 28, Issue 6, 2007, Pages 275-282

  Pike, Andrew ^a,b   Cook, Susan M ^a   Watt, Alan P ^a   Scott Stevens, Paul ^a   Rosahl, Thomas W ^a   McKernan, Ruth M ^a   Pym, Luanda J ^a   Guiblin, Alec ^a   Moyes, Christopher ^a   Sohal, Bindi ^a   Atack, John R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

Benzodiazepines; Brain concentration; Occupancy; Specific binding

Indexed keywords

3 CYCLOPENTYL 5 METHYL 2 (2 METHYL 2H 1,2,4 TRIAZOL 3 YLMETHOXY) 8 PHENYL IMIDAZO[1,2 D] 1,2,4 TRIAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 7 CYCLOBUTYL 6 (2 METHYL 2H 1,2,4 TRIAZOL 3 YLMETHOXY) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; METHYLCELLULOSE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; BRAIN HOMOGENATE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG STRUCTURE; HYPOTHESIS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR BINDING; RECEPTOR OCCUPANCY; WILD TYPE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BENZODIAZEPINES; BENZODIAZEPINONES; BINDING SITES; BINDING, COMPETITIVE; BRAIN; BRAIN CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; FLUNITRAZEPAM; GABA MODULATORS; INJECTIONS, INTRAVENOUS; LIGANDS; MALE; MICE; MICE, MUTANT STRAINS; PYRIDAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; TISSUE DISTRIBUTION; TRIAZINES;

EID: 34548754587     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.553     Document Type: Article

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