Spongolactams, farnesyl transferase inhibitors from a marine sponge: Isolation through an LC/MS-guided assay, structures, and semisyntheses

Journal of Organic Chemistry

Volumn 72, Issue 19, 2007, Pages 7190-7198

  Mori, Daisuke ^a   Kimura, Yuko ^a   Kitamura, Shigeyuki ^a   Sakagami, Youji ^a   Yoshioka, Yukio ^b   Shintani, Tomoaki ^b   Okamoto, Tetsuji ^b   Ojika, Makoto ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL TRANSFERASE INHIBITORS; OKINAWAN MARINE SPONGE; SPONGOLACTAMS;

BIOACTIVITY; BIOASSAY; BIOSYNTHESIS; CYTOTOXICITY; METABOLITES; TUMORS;

ENZYME INHIBITION;

DITERPENE; FURANODITERPENE; LACTAM DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SPONGOLACTAM A; SPONGOLACTAM B; SPONGOLACTAM C; SPONGOLACTAM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; LACTAMS; MASS SPECTROMETRY; SACCHAROMYCES CEREVISIAE;

EID: 34548711777     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo071003y     Document Type: Article

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