Detection of the MPL W515L mutation in bone marrow core biopsy specimens with essential thrombocythemia using the TaqMan assay

Human Pathology

Volumn 38, Issue 10, 2007, Pages 1581-1582

  Laurent, Camille ^a,b   Demas, Véronique ^c   Delabesse, Eric ^c   Brousset, Pierre ^c  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b CHU PURPAN   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOPOIETIN RECEPTOR;

ALLELE; BONE MARROW BIOPSY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC TEST; DNA DETERMINATION; GENE MUTATION; GENOME ANALYSIS; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LETTER; MUTATIONAL ANALYSIS; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE COUNT; THROMBOCYTHEMIA;

BIOPSY; BONE MARROW CELLS; HUMANS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, THROMBOPOIETIN; THROMBOCYTHEMIA, HEMORRHAGIC;

EID: 34548672143     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2007.06.001     Document Type: Letter

References (4)

1. Bousquet M., LeGuellec S., Quelen C., Rigal-Huguet F., Delsol G., and Brousset P. Frequent detection of the JAK2 V617F mutation in bone marrow core biopsy specimens from chronic myeloproliferative disorders using the TaqMan polymerase chain reaction single nucleotide polymorphism genotyping assay: a retrospective study with pathologic correlations. Hum Pathol 37 (2006) 1458-1464
2. Campbell P.J., and Green A.R. The myeloproliferative disorders. N Engl J Med 355 (2006) 2452-2466
3. Pikman Y., Lee B.H., Mercher T., et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 3 (2006) e270
4. Pardanani A.D., Levine R.L., Lasho T., et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 108 (2006) 3472-3476