Effect of cyclophosphamide treatment on selected lysosomal enzymes in the kidney of rats

Experimental and Toxicologic Pathology

Volumn 59, Issue 2, 2007, Pages 143-149

  Abraham, Premila ^a   Indirani, K ^a   Sugumar, Emila ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Cyclophosphamide; Lysosomal enzymes; Nephrotoxicity; Protein accumulation; Rat

Indexed keywords

ACETYLGLUCOSAMINIDASE; ACID PHOSPHATASE; BETA GLUCURONIDASE; CREATININE; CYCLOPHOSPHAMIDE; LYSOSOME ENZYME; SODIUM CHLORIDE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; EDEMA; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; GLOMERULONEPHRITIS; HISTOPATHOLOGY; KIDNEY INJURY; KIDNEY INTERSTITIUM; KIDNEY MASS; KIDNEY TUBULE; MALE; NEPHROTOXICITY; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SINGLE DRUG DOSE; TIME; UREA BLOOD LEVEL; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

EID: 34548646042     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2007.05.003     Document Type: Article

References (37)

1. Abboud H.E. Growth factors and diabetic nephropathy: an overview. Kidney Int 52 (1997) S3-S6
2. Ahluwalia A., Maggi C.A., Santicioli P., Lecci A., and Giuliani S. Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder. Br J Pharmacol 111 (1994) 1017-1022
3. Bouby N., Trinh-Trang-Tan M.M., and Laouari D. Role of urinary concentrating process in the renal effects of high protein intake. Kidney Int 34 (1988) 4-12
4. Davison J.M., and Lindheimer M.D. Changes in renal hemodyanamics and kidney weight during pregnancy in the unanaesthetised rat. J Physiol 310 (1980) 129-136
5. Dechant K.L., Brogden R.N., Pilkington T., and Faulds D. Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer. Drugs 42 (1991) 428-467
6. Dell'Angelica E.C., Mullins C., Caplan S., and Bonifacino J.S. Lysosome related organelles. FASEB J 14 (2000) 1265-1278
7. Dianzani M.U. Lysosome changes in liver injury. In: DeReuck A.V.S., and Cameron M.P. (Eds). Ciba foundation symposium on lysosomes (1963), Little, Brown and Co., Boston 335-351
8. Fine L.G., Holley R.W., Nasri H., and Badie-Dezfooly B. BSC-1 growth inhibitor transforms a mitogenic stimulus into ahypertrophic stimulus for renal proximal tubular cells: Relationship to Na+/H+ antiport activity. Proc Natl Acad Sci USA 82 (1985) 6163-6166
9. Franch H.A., and Preisig P.A. NH4Cl induced hypertrophy is mediated by weak base effects and is independent of cell cycle processes. Am J Physiol 270 (1996) C932-C938
10. Franch H.A., Curtis P.V., and Mitch W.E. Mechanism of renal tubular cell hypertrophy: mitogen induced suppression of proteolysis. Am J Physiol 273 (1997) C843-C851
11. Jurgens H. Recent advances in childhood cancer. Eur J Cancer 33A (1997) S15-S22
12. Kalhorn T.F., Howald W.N., Cole S., Phillips B., Wang J., Slattery J.T., et al. Rapid quantitation of cyclophosphamide metabolites in plasma by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 835 (2006) 105-113
13. Kawai Y., and Anno K. Mucopolysaccharide-degrading enzymes from the liver of the squid, ommastrephes sloami pacificus I. Hyaluronidase. Biochim Biophys Acta 242 (1971) 428-436
14. Kerbusch T., de Kraker J., Keizer H.J., van Putten J.W., Groen H.J., Jansen R.L., et al. Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites. Clin Pharmacokinet 40 (2001) 41-62
15. Khandkar M.A., and Parmar D.V. Is activation of lysosomal enzymes responsible for paracetamol-induced hepatotoxicity and nephrotoxicity?. J Pharm Pharmacol 48 (1996) 437-440
16. Kyaw A.A., Aung T., and Htut T. Lysosomal enzymes activities in normals and in patients with chronic liver disease. Clin Chim Acta 131 (1983) 317-323
17. Ling H., Vamvakas S., Schaefer L., Schnittler H.J., and Schaefer R.M. Angiotensin II induced cell hypertrophy: potential role of impaired proteolytic activity in cultured LLC-PK1 cells. Nephrol Dial Transplant 10 (1995) 1305-1312
18. Ling H., Vamvakas S., and Gekle M. Role of lysosomal cathepsin activities in cell hypertrophy induced by NH4Cl in cultured renal proximal tubule cells. J Am Soc Nephrol 7 (1996) 73-80
19. Liu B., and Preisig P.A. Renal hypertrophy following uninephrectomy (Unx) is associated with activation of cdk2/cyclin E, but not cdk4/cyclinD1 kinase (abstract). J Am Soc Nephrol 8 (1997) 424
20. Liu B., and Preisig P.A. Compensatory renal hypertrophy (CRH) is mediated by both cell cycle dependant and independent growth processes (abstract). J Am Soc Nephrol 9 (1998) 444
21. Lotpeich W.D. Renal hypertrophy in metabolic acidosis and its relation to ammonia excretion. Am J Physiol 208 (1965) 1135-1142
22. Lowry O.H., Rosebrough M.J., and Farr A.L. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
23. Mathews B.F. Growth of the maternal kidneys in pregnant mice. Proc J Physiol 273 (1977) 84P
24. Mohrmann M., Ansorge S., Schmich U., Schonfeld B., and Brandis M. Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture. Pediatr Nephrol 8 (1994) 157-163
25. Okamura T., Garland E.M., Taylor R.J., Johansson S.L., and Cohen S.M. The effect of cyclophosphamide administration on the kidney of the rat. Toxicol Lett 63 (1992) 261-276
26. Olbricht C.J., and Fink M. Alterations in lysosomal enzymes of the proximal tubule in gentamicin nephrotoxicity. Kidney Int 39 (1991) 639-646
27. Pratt C.B., Meyer W.H., Jenkins J.J., Avery L., McKay C.P., Wyatt R.J., et al. Ifosfamide, Fanconi's syndrome, and rickets. J Clin Oncol 9 (1991) 1495-1499
28. Rosenblit P.D., Metzger R.P., and Wick A.N. Effect of streptozotocin diabetes on acid phosphatase and selected glycosidase activities of serum and various rat organs. Proc Soc Exp Biol Med 145 (1974) 244-248
29. Rossi R., Godde A., Kleinebrand A., Riepenhausen M., Boos J., Ritter J., et al. Unilateral nephrectomy and cisplatin as risk factors of ifosfamide-induced nephrotoxicity: analysis of 120 patients. J Clin Oncol 12 (1994) 159-165
30. Schwartz G., Gordjani N., Benesic A., Freudinger R., Wollny B., and Kirchhoff A. Gekle MChloroacetaldehyde and acroleun induced death of human proximal tubule cells. Pediatr Nephrol 21 (2006) 60-67
31. Seyer-Hansen K. Renal hypertrophy in experimental diabetes mellitus. Kidney Int 23 (1983) 643-646
32. Seyer-Hansen K., Hansen J., and Gunderson H.J.G. Renal hypertrophy in experimental diabetes. Diabetologia 18 (1980) 501-505
33. Sugumar E., Indirani K., and Abraham P. Normal plasma creatinine levels despite histological evidence of renal damage in cyclophosphamide treated rats. Clin Chim Acta 376 (2007) 244-245
34. Vengerovaski A.I., and Saratikov A.S. The effect of hepatotoxins on the activity of organelle-specific enzymes and metabolism of liver lipids. Vopr Med Khim 35 (1989) 87-91
35. Whiting P.H., and Brown P.A. The relationship between enzymuria and kidney enzyme activities in experimental gentamicin toxicity. Ren Fail 18 (1996) 899-909
36. Woodland C., Ito S., Granvil C.P., Wainer I.W., Klein J., and Koren G. Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites. Life Sci 68 (2000) 109-117
37. Ziyadeh F.N., Goldfarb S., and Kern E.F.O. Diabetic nephropathy: metabolic and biochemical mechanisms. In: Brenner B.M., and Stein J.H. (Eds). Contemporary issues in nephrology (1989), Churchill Livingstone, New York 87-113