Is activation of lysosomal enzymes responsible for paracetamol-induced hepatotoxicity and nephrotoxicity?

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 4, 1996, Pages 437-440

  Khandkar, Milind A ^a   Parmar, Dipak V ^a   Das, Mita ^a   Katyare, Surendra S ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; CATHEPSIN D; DEOXYRIBONUCLEASE II; LYSOSOME ENZYME; PARACETAMOL; RIBONUCLEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG OVERDOSE; ENZYME ACTIVATION; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER TOXICITY; LIVER WEIGHT; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN;

EID: 0029890027     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb05948.x     Document Type: Article

References (12)

1. Barret, A. J., Heath, S. S. (1977) Lysosomal enzymes. In: Dingle, J. T. (ed.) Lysosome. Laboratory handbook, North-Holland, Amsterdam, pp 19-145
2. Burcham, P. C., Harman, A. W. (1990) Mitochondrial dysfunction in paracetamol hepatotoxicity: in vitro studies in isolated mouse hepatocytes. Toxicol. Lett. 50: 37-48
3. Ginsberg, G. L., Cohen, S. D. (1985) Plasma membrane alterations and covalent binding to organelles after an hepatotoxic dose of acetaminophen. Toxicologist 5: 154
4. Katyare, S. S., Satav, J. G. (1989) Impaired mitochondrial oxidative energy metabolism following paracetamol-induced hepatotoxicity in the rat. Br. J. Pharmacol. 96: 51-58
5. Kleinman, J. G., Breitenfield, R. V., Roth, D. A. (1980) Acute renal failure associated with acetaminophen ingestion: report of a case and review of the literature. Clin. Nephrol. 14: 201-205
6. Meyers, L. L., Beierschmitt, W. P., Khairallah, E. A., Cohen, S. D. (1988) Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice. Toxicol. App. Pharmacol. 93: 378-387
7. Parmar, D. V., Ahmed, G., Khandkar, M. A., Katyare, S. S. (1995) Mitochondrial ATPase: a target for paracetamol-induced hepatotoxicity. Eur. J. Pharmacol. 293:225-229
8. Satav, J. G., Katyare, S. S. (1981) Thyroid hormone and cathepsin D activity in the rat liver, kidney and brain. Experientia 37: 100-101
9. 2+ endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death. Toxicol. Appl. Pharmacol. 112: 32-40
10. Szego, C. M., Piefras, R. J. (1984) Lysosomal functions in cellular activation: propogation of the action of hormones and other effectors. Int. Rev. Cytol. 88: 238-239
11. Tirmenstein, M. A., Nelson, S. D. (1989) Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver. J. Biol. Chem. 264: 9814-9819
12. Vermeulen, N. P. E., Bessems, J. G. M., Van De Straat, R. (1992) Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism based prevention. Drug Metab. Rev. 24: 367-407