Studies on neurosteroids. XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS

Steroids

Volumn 72, Issue 13, 2007, Pages 865-874

  Higashi, Tatsuya ^a   Yokoi, Hiroyuki ^a   Maekubo, Hitoe ^a   Honda, Ayako ^a   Shimada, Kazutake ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Derivatization; Liquid chromatography mass spectrometry; Rat brain; Sex difference; Stress; Tetrahydrocorticosterone

Indexed keywords

2 NITRO 4 TRIFLUOROMETHYLPHENYL HYDRAZONE DERIVATIVE; 3ALPHA,5ALPHA TETRAHYDROCORTISONE; 3ALPHA,5BETA TETRAHYDROCORTISONE; 3BETA,5ALPHA TETRAHYDROCORTISONE; 3BETA,5BETA TETRAHYDROCORTISONE; CORTICOSTERONE; DINITROBENZOYL ESTER DERIVATIVE; ESTER DERIVATIVE; HYDRAZONE DERIVATIVE; NEUROSTEROID; TETRAHYDROCORTISONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE DETERMINATION; IMMOBILIZATION; ISOMER; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; RAT; SEX DIFFERENCE;

ANIMALS; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; CORTICOSTERONE; IMMOBILIZATION; ISOMERISM; MASS SPECTROMETRY; RATS; RATS, WISTAR; STEROIDS;

RATTUS;

EID: 34548640823     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2007.07.008     Document Type: Article

References (25)

1. Patel A., and Bulloch K. Type II glucocorticoid receptor immunoreactivity in the mossy cells of the rat and the mouse hippocampus. Hippocampus 13 (2003) 59-66
2. Armanini M.P., Hutchins C., Stein B.A., and Sapolsky R.M. Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent. Brain Res 532 (1990) 7-12
3. 2+ elevation in cultured rat hippcapal neurons. J Neurochem 83 (2002) 1441-1451
4. 2+ elevation in mouse hippocampal slices. Biochem Biophys Res Commun 321 (2004) 510-513
5. Strömberg J., Bäckström T., and Lundgren P. Rapid non-genomic effect of glucocorticoid metabolites and neurosteroids on the γ-aminobutyric acid-A receptor. Eur J Neurosci 21 (2005) 2083-2088
6. Higashi T., Takido N., and Shimada K. Studies on neurosteroids XVII. Analysis of stress-induced changes in neurosteroid levels in rat brains using liquid chromatography-electron capture atmospheric pressure chemical ionization-mass spectrometry. Steroids 70 (2005) 1-11
7. Higashi T., Ninomiya Y., Iwaki N., Yamauchi A., Takayama N., and Shimada K. Studies on neurosteroids XVIII. LC-MS analysis of changes in rat brain and serum testosterone levels induced by immobilization stress and ethanol administration. Steroids 71 (2006) 609-617
8. Higashi T., Nagahama A., Otomi N., and Shimada K. Studies on neurosteroids XIX. Development and validation of liquid chromatography-tandem mass spectrometric method for determination of 5α-reduced pregnane-type neurosteroids in rat brain and serum. J Chromatogr B 848 (2007) 188-199
9. Wang Y., Karu K., and Griffiths W.J. Analysis of neurosterols and neurosteroids by mass spectrometry. Biochimie 89 (2007) 182-191
10. Liu S., Sjövall J., and Griffiths W.J. Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatography-electrospray mass spectrometry. Anal Chem 75 (2003) 5835-5846
11. Higashi T., and Shimada K. Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography-mass spectrometry. Anal Bioanal Chem 378 (2004) 875-882
12. Higashi T. Trace determination of steroids causing age-related diseases using LC/MS combined with detection-oriented derivatization. Chem Pharm Bull 54 (2006) 1479-1485
13. Higashi T., Takido N., Yamauchi A., and Shimada K. Electron-capturing derivatization of neutral steroids for increasing sensitivity in liquid chromatography/negative atmospheric pressure chemical ionization-mass spectrometry. Anal Sci 18 (2002) 1301-1307
14. Hosoda H., Osanai K., Fukasawa I., and Nambara T. Chemical conversion of corticosteroids to 3α,5α-tetrahydro derivatives. Synthesis of allotetrahydrocortisol glucuronides and allotetrahydrocortisone glucuronides. Chem Pharm Bull 38 (1990) 1949-1952
15. Singh G., Gutierrez A., Xu K., and Blair I.A. Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range. Anal Chem 72 (2000) 3007-3013
16. Hayen H., Jachmann N., Vogel M., and Karst U. LC-electron capture-APCI(-)-MS determination of nitrobenzoxadiazole derivatives. Analyst 128 (2003) 1365-1372
17. Higashi T., Takayama N., Kyutoku M., Shimada K., Koh E., and Namiki M. Liquid chromatography-mass spectrometric assay of androstenediol in prostatic tissue: influence of androgen deprivation therapy on its level. Steroids 71 (2006) 1007-1013
18. Higashi T., Takayama N., Nishio T., Taniguchi E., and Shimada K. Procedure for increasing the detection responses of estrogens in LC-MS based on introduction of a nitrobenzene moiety followed by electron capture atmospheric pressure chemical ionization. Anal Bioanal Chem 386 (2006) 658-665
19. Barbaccia M.L., Serra M., Purdy R.H., and Biggio G. Stress and neuroactive steroids. Int Rev Neurobiol 46 (2001) 243-272
20. Higashi T, Nagahama A, Mukai Y, Shimada K. Studies on neurosteroids XXII. Liquid chromatography-tandem mass spectrometric method for profiling rat brain 3-oxo-4-ene-neuroactive steroids. Biomed Chromatogr, in press.
21. Higashi T., Nishio T., Yokoi H., Ninomiya Y., and Shimada K. Studies on neurosteroids XXI. An improved liquid chromatography-tandem mass spectrometric method for determination of 5α-androstane-3α,17β-diol in rat brains. Anal Sci 23 (2007) 1015-1019
22. Kiyokage E., Toida K., Suzuki-Yamamoto T., and Ishimura K. Localization of 5α-reductase in the rat main olfactory bulb. J Comp Neurol 493 (2005) 381-395
23. Normington K., and Russell D.W. Tissue distribution and kinetic characteristics of rat steroid 5α-reductase isozymes. Evidence for distinct physiological functions. J Biol Chem 267 (1992) 19548-19554
24. Poletti A., Coscarella A., Negri-Cesi P., Colciago A., Celotti F., and Martini L. 5α-Reductase isozymes in the central nervous system. Steroids 63 (1998) 246-251
25. van Broekhoven F., and Verkes R.J. Neurosteroids in depression: a review. Psychopharmacology 165 (2003) 97-110