Metabolic effects of a novel silicate inositol complex of the nitric oxide precursor arginine in the obese insulin-resistant JCR:LA-cp rat

Metabolism: Clinical and Experimental

Volumn 56, Issue 10, 2007, Pages 1318-1325

  Proctor, Spencer D ^a   Kelly, Sandra E ^a   Vine, Donna F ^a   Russell, James C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; CHOLESTEROL; INOSITOL; INSULIN; NITRIC OXIDE; PHOSPHOLIPID; SILICATE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FEMALE; FOOD INTAKE; GLOMERULOSCLEROSIS; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MICROANGIOPATHY; NONHUMAN; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RAT; RAT STRAIN; VASCULAR DISEASE; WEIGHT GAIN;

ANIMALS; ARGININE; BLOOD GLUCOSE; BODY WEIGHT; EATING; FEMALE; INOSITOL; INSULIN; INSULIN RESISTANCE; LIPIDS; MALE; NITRIC OXIDE; OBESITY; RATS; RATS, INBRED STRAINS; SILICATES; SILICON;

EID: 34548624596     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2007.05.022     Document Type: Article

References (39)

1. Steiner G. Hyperinsulinemia and hypertriglyceridemia. J Int Med 736 Suppl (1994) 23-26
2. Després J.-P., Lamarche B., Mauriège P., Cantin B., Dagenais G.R., Moorjani S., et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 334 (1996) 952-957
3. Uusitupa M.I., Niskanen L.K., Siitonen O., Voutilainen E., and Pyorala K. 5-year incidence of atherosclerotic vascular disease in relation to general risk factors, insulin level, and abnormalities in lipoprotein composition in non-insulin-dependent diabetic and nondiabetic subjects. Circulation 82 (1990) 27-36
4. O'Brien S.F., and Russell J.C. Insulin resistance and vascular wall function: lessons from animal models (review). Endocrinol Metab 4 (1997) 155-162
5. Franks S., McCarthy M.I., and Hardy K. Development of polycystic ovary syndrome: involvement of genetic and environmental factors. Int J Androl 29 (2006) 278-285
6. Essah P.A., and Nestler J.E. The metabolic syndrome in polycystic ovary syndrome. J Endocrinol Invest 29 (2006) 270-280
7. Radomski M.W., and Salas E. Nitric oxide-biological mediator, modulator and factor of injury: its role in the pathogenesis of atherosclerosis. Atherosclerosis 118: (1995) S69-S80
8. Russell J.C., McKendrick J.D., Dubé G.P., Dolphin P.J., and Radomski M.W. Effects of LY117018 and the estrogen analogue, 17α-ethinylestradiol, on vascular reactivity, platelet aggregation, and lipid metabolism in the insulin-resistant JCR:LA-cp rat: role of nitric oxide. J Cardiovasc Pharmacol 37 (2001) 119-128
9. Loscalzo J. l-Arginine and atherothrombosis. J Nutr 134 (2004) 2798S-2800S
10. Gornik H.L., and Creager M.A. Arginine and endothelial and vascular health. J Nutr 134 (2004) 2880S-2887S
11. Bayliss C. Session III: arginine and pathophysiology I-discussion summary. J Nutr 134 (2004) 2818S-2819S
12. Proctor S.D., Kelly S.E., and Russell J.C. A novel complex of arginine-silicate improves micro- and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR:LA-cp rats. Diabetologia 48 (2005) 1925-1932
13. Russell J.C., Kelly S.E., and Proctor S.D. The JCR:LA-cp rat: animal model of the metabolic syndrome exhibiting micro- and macro-vascular disease. In: Shafrir E. (Ed). Animal models of diabetes (2007), CRC Press, Boca Raton (Fla) 157-180
14. O'Brien S.F., Russell J.C., and Davidge S.T. Vascular wall dysfunction in JCR:LA-cp rats: effects of age and insulin resistance. Am J Physiol 277 (1999) C987-C993
15. Juturu V., Komorowski J.R., and Gudi R. Orally administered arginine silicate inositol complex is not clastogenic in Chinese hamster ovary cells. FASEB J 18 (2004) A 869 [Abstract]
16. Komorowski J.R., Juturu V., and Gudi R. Arginine silicate inositol complex is not toxic in mouse micronucleus assay. FASEB J 18 (2004) A 869 [Abstract]
17. Russell J.C., Amy R.M., Graham S., and Dolphin P.J. Effect of castration on hyperlipidemic, insulin resistant JCR:LA-corpulent rats. Atherosclerosis 100 (1993) 113-122
18. Russell J.C., and Amy R.M. Early atherosclerotic lesions in a susceptible rat model: the LA/N-corpulent rat. Atherosclerosis 60 (1986) 119-129
19. Juturu V., Komorowski J.R., and Roa K.S. Arginine silicate inositol complex does not induce mutation in the AMES bacterial reverse mutation test. FASEB J 18 (2004) A 869 [Abstract]
20. Russell J.C., Amy R.M., Graham S.E., Dolphin P.J., Wood G.O., and Bar-Tana J. Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by β,β′-tetramethylhexadecanedioic acid [MEDICA 16]. Arterioscler Thromb Vasc Biol 15 (1995) 918-923
21. Russell J.C., Graham S.E., and Dolphin P.J. Glucose tolerance and insulin resistance in the JCR:LA-cp rat: effect of miglitol (Bay m1099). Metabolism 48 (1999) 701-706
22. Russell J.C., Bar-Tana J., Shillabeer G., Lau D.C.W., Richardson M., Wenzel L.M., et al. Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16. Diabetes 47 (1998) 770-778
23. Vance J.E., and Russell J.C. Hypersecretion of VLDL, but not HDL, by hepatocytes from the JCR:LA-corpulent rat. J Lipid Res 31 (1990) 1491-1501
24. Elam M.B., Wilcox H.G., Cagen L.M., Deng X., Raghow R., Kumar P., et al. Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat. J Lipid Res 42 (2001) 2039-2048
25. Russell J.C., Graham S.E., and Richardson M. Cardiovascular disease in the JCR:LA-cp rat. Mol Cell Biochem 188 (1998) 113-126
26. Russell J.C., Ravel D., Pégorier J.-P., Delrat P., Jochemsen R., O'Brien S.F., et al. Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat. J Pharmacol Exp Ther 295 (2000) 753-760
27. Kuksis A., Myher J.J., Geher K., Hoffman A.G., Breckenridge W.C., Jones G.J., et al. Comparative determination of plasma cholesterol and triacylglycerol levels by automated gas-liquid chromatographic and autoanalyzer methods. J Chromatogr 146 (1978) 393-412
28. Leung F.Y., and Edmond P. Determination of silicon in serum and tissue by electrothermal atomic absorption spectrometry. Clin Biochem 30 (1997) 399-403
29. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and 15N nitrate in biological fluids. Anal Biochem 126 (1982) 131-138
30. Adler A.J., Etzion Z., and Berlyne G.E. Uptake, distribution, and excretion of 31 silicon in normal rats. Am J Physiol 251 (1986) E670-E673
31. Seaborn C.D., and Nielson F.H. Dietary silicon and arginine affect mineral element composition of rat femur and vertebra. Biol Trace Elem Res 89 (2002) 239-250
32. Seaborn C.D., Briske-Anderson M., and Nielson F.H. An interaction between dietary silicon and arginine affects immune function indicated by con-A-induced DNA synthesis of rat splenic T-lymphocytes. Biol Trace Elem Res 87 (2002) 133-142
33. O'Brien S.F., Russell J.C., Dolphin P.J., and Davidge S.T. Vascular wall function in insulin-resistant JCR:LA-cp rats: role of male and female sex. J Cardiovasc Pharmacol 36 (2000) 176-181
34. Russell J.C., Amy R.M., Manickavel V., Ahuja S.K., and Rajotte R.V. Insulin resistance and impaired glucose tolerance in the atherosclerosis prone LA/N-corpulent rat. Arteriosclerosis 7 (1987) 620-626
35. Brunner F., Wölkert G., Russell J.C., and Wascher T. Vascular dysfunction and myocardial contractility in the JCR:LA-corpulent rat. Cardiovasc Res 36 (2000) 150-158
36. Pederson R.A., Campos R.V., Buchan A.M.J., Chisholm C.B., Russell J.C., and Brown J.C. Comparison of the enteroinsular axis in two strains of obese rats: the fatty Zucker and the JCR:LA-corpulent. Int J Obes 15 (1991) 461-470
37. Russell J.C., Koeslag D.G., Amy R.M., and Dolphin P.J. Plasma lipid secretion and clearance in the hyperlipidemic JCR:LA-corpulent rat. Arteriosclerosis 9 (1989) 869-876
38. Richardson M., Schmidt A.M., Graham S.E., Achen B., DeReske M., and Russell J.C. Vasculopathy and insulin resistance in the JCR:LA-cp rat. Atherosclerosis 138 (1998) 135-146
39. Russell J.C., Kelly S.E., and Schäfer S. Vasopeptidase inhibition improves insulin sensitivity and endothelial function in the JCR:LA-cp rat. J Cardiovasc Pharmacol 44 (2004) 258-265