Semliki Forest virus vectors with mutations in the nonstructural protein 2 gene permit extended superinfection of neuronal and non-neuronal cells

Journal of NeuroVirology

Volumn 13, Issue 4, 2007, Pages 353-363

  Ehrengruber, Markus ^a   Goldin, Alan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alphavirus; Baby hamster kidney 21 (BHK) cell; Homologous interference; Monomeric red fluorescent protein; Mouse cortical neuron; Superinfection exclusion

Indexed keywords

COMPLEMENTARY DNA; FLUORESCENT DYE; NONSTRUCTURAL PROTEIN 2; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENETIC CODE; HIPPOCAMPUS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEMLIKI FOREST ALPHAVIRUS; SUPERINFECTION; VIRUS PARTICLE; VIRUS STRAIN; WILD TYPE;

ALPHAVIRUS INFECTIONS; ANIMALS; CELL LINE; CEREBRAL CORTEX; CLONING, MOLECULAR; CRICETINAE; CYSTEINE ENDOPEPTIDASES; FLUORESCENT DYES; GENETIC VECTORS; KIDNEY; LUMINESCENT PROTEINS; MICE; NEURONS; POINT MUTATION; RATS; SEMLIKI FOREST VIRUS; SUPERINFECTION; TRANSGENES;

ALPHAVIRUS; CRICETINAE; RABBIT FIBROMA VIRUS; RATTUS; SEMLIKI FOREST VIRUS;

EID: 34548612765     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280701393204     Document Type: Article

References (32)

1. Agapov, E. V., Frolov, I., Lindenbach, B. D., Pragai, B. M., Schlesinger, S. and Rice, C. M. (1998) Non-cytopathogenic Sindbis RNA vectors for heterologous gene expression. Proc Natl Acad Sci U S A, 95, pp. 12989-12994.
2. Bausch, S. B., Patterson, T. A., Ehrengruber, M. U., Lester, H. A., Davidson, N. and Chavkin, C. (1995) Colocalization of mu opioid receptors with GIRK1 potassium channels in rat brain: An immunocytochemical study. Recept Channels, 3, pp. 221-241.
3. Bredenbeek, P. J., Frolov, I., Rice, C. M. and Schlesinger, S. (1993) Sindbis virus expression vectors: Packaging of RNA replicons by using defective helper RNAs. J Virol, 67, pp. 6439-6446.
4. Campbell, R. E., Tour, O., Palmer, A. E., Steinbach, P. A., Baird, G. S., Zacharias, D. A. and Tsien, R. Y. (2002) A monomeric red fluorescent protein. Proc Natl Acad Sci U S A, 99, pp. 7877-7882.
5. DeSouza, S., States, B. A. and Ziff, E. B. (2002) Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters. J Neurosci, 22, pp. 3493-3503.
6. Dryga, S. A., Dryga, O. A. and Schlesinger, S. (1997) Identification of mutations in a Sindbis virus variant able to establish persistent infection in BHK cells: The importance of a mutation in the nsP2 gene. Virology, 228, pp. 74-83.
7. Ehrengruber, M. U. (2002) Alphaviral gene transfer in neurobiology. Brain Res Bull, 59, pp. 13-22.
8. Ehrengruber, M. U. (2002) Alphaviral vectors for gene transfer into neurons. Mol Neurobiol, 26, pp. 183-201.
9. Ehrengruber, M. U., Hennou, S., Büeler, H., Naim, H. Y., Déglon, N. and Lundstrom, K. (2001) Gene transfer into neurons from hippocampal slices: Comparison of recombinant Semliki Forest virus, adenovirus, adeno-associated virus, lentivirus, and measles virus. Mol Cell Neurosci, 17, pp. 855-871.
10. Ehrengruber, M. U. and Lundstrom, K. (2002) Semliki Forest virus and Sindbis virus vectors. Current protocols in human genetics, pp. 12.2.1-12.2.23. John Wiley & Sons, New York
11. Ehrengruber, M. U., Lundstrom, K., Schweitzer, C., Heuss, C., Schlesinger, S. and Gähwiler, B. H. (1999) Recombinant Semliki Forest virus and Sindbis virus efficiently infect neurons in hippocampal slice cultures. Proc Natl Acad Sci U S A, 96, pp. 7041-7046.
12. Fazakerley, J. K., Boyd, A., Mikkola, M. L. and Kääriäinen, L. (2002) A single amino acid change in the nuclear localization sequence of the nsP2 protein affects the neurovirulence of Semliki Forest virus. J Virol, 76, pp. 392-396.
13. Frolov, I., Agapov, E., Hoffman, T. A., Prágai, B. M., Lippa, M., Schlesinger, S. and Rice, C. M. (1999) Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells. J Virol, 73, pp. 3854-3865.
14. Garmashova, N., Gorchakov, R., Frolova, E. and Frolov, I. (2006) Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription. J Virol, 80, pp. 5686-5696.
15. Graham, A., Walker, R., Baird, B., Hahn, C. N. and Fazakerley, J. K. (2006) CNS gene therapy applications of the Semliki Forest virus 1 vector are limited by neurotoxicity. Mol Ther, 13, pp. 631-635.
16. Johnston, R. E., Wan, K. and Bose, H. R. (1974) Homologous interference induced by Sindbis virus. J Virol, 14, pp. 1076-1082.
17. Kim, K. H., Rümenapf, T., Strauss, E. G. and Strauss, J. H. (2004) Regulation of Semliki Forest virus RNA replication: A model for the control of alphavirus pathogenesis in invertebrate hosts. Virology, 323, pp. 153-163.
18. Massengill, J. L., O'Dowd, D. K. and Smith, M. A. (1997) Agrin gene expression in mouse somatosensory cortical neurons during development in vivo and in cell culture. Neuroscience, 79, pp. 191-201.
19. Liang, X. H., Jiang, H. H. and Levine, B. (1997) Expression of a biologically active antiviral antibody using a Sindbis virus vector system. Mol Immunol, 34, pp. 907-917.
20. Liljeström, P. and Garoff, H. (1991) A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Biotechnology, 9, pp. 1356-1361.
21. Lundstrom, K. (2007) Alphaviruses: Semliki Forest virus and Sindbis virus as gene delivery vectors. Gene transfer: Delivery and expression of DNA and RNA, a laboratory manual, pp. 327-348. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
22. Lundstrom, K., Abenavoli, A., Malgaroli, A. and Ehrengruber, M. U. (2003) Novel Semliki Forest virus vectors with reduced cytotoxicity and temperature-sensitivity for long-term enhancement of transgene expression. Mol Ther, 7, pp. 202-209.
23. Maletic-Savatic, M., Malinow, R. and Svoboda, K. (1999) Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science, 283, pp. 1923-1927.
24. Perri, S., Driver, D. A., Gardner, J. P., Sherrill, S., Belli, B. A., Dubensky Jr, T. W. and Polo, J. M. (2000) Replicon vectors derived from Sindbis virus and Semliki Forest virus that establish persistent replication in host cells. J Virol, 74, pp. 9802-9807.
25. Rikkonen, M. (1996) Functional significance of the nuclear-targeting and NTP-binding motifs of Semliki Forest virus nonstructural protein nsP2. Virology, 218, pp. 352-361.
26. Sawicki, D. L., Perri, S., Polo, J. M. and Sawicki, S. G. (2006) Role for nsP2 proteins in the cessation of alphavirus minus-strand synthesis by host cells. J Virol, 80, pp. 360-371.
27. 1b-adrenergic receptor and G protein subunits in mammalian cell lines using the Semliki Forest virus expression system. J Recept Signal Transduct Res, 19, pp. 369-378.
28. Schlesinger, S. (2000) Alphavirus expression vectors. Adv Virus Res, 55, pp. 565-577.
29. Singh, I. R., Suomalainen, M., Varadarajan, S., Garoff, H. and Helenius, A. (1997) Multiple mechanisms for the inhibition of entry and uncoating of superinfecting Semliki Forest virus. Virology, 231, pp. 59-71.
30. Strauss, J. H. and Strauss, E. G. (1994) The alphaviruses: Gene expression, replication, and evolution. Microbiol Rev, 58, pp. 491-562.
31. Takkinen, K. (1986) Complete nucleotide sequence of the nonstructural genes of Semliki Forest virus. Nucleic Acids Res, 14, pp. 5667-5682.
32. Tuittila, M. T., Santagati, M. G., Röyttä, M., Määttä, J. A. and Hinkkanen, A. E. (2000) Replicase complex genes of Semliki Forest virus confer lethal neurovirulence. J Virol, 74, pp. 4579-4589.