Alphaviral vectors for gene transfer into neurons

Molecular Neurobiology

Volumn 26, Issue 2-3, 2002, Pages 183-201

  Ehrengruber, Markus U ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Expression vector; Green fluorescent protein; Hippocampus; RNA virus; Semliki Forest virus; Sindbis virus

Indexed keywords

CALCIUM ION; GREEN FLUORESCENT PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); RECOMBINANT PROTEIN; VIRUS RNA; VIRUS VECTOR;

ALPHA VIRUS; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HIPPOCAMPUS; LIGAND BINDING; NERVE CELL; NONHUMAN; RAT; RNA VIRUS; SEMLIKI FOREST ALPHAVIRUS; SINDBIS VIRUS; TEMPERATURE DEPENDENCE; VIRUS REPLICATION;

EID: 0036773431     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1385/MN:26:2-3:183     Document Type: Article

References (91)

1. Schlesinger S. and Schlesinger M. J. (2001) Togaviridae: The viruses and their replication, in Fields Virology. (Knipe D. M. and Howley P. M., eds.) Lippincott Williams & Wilkins, Philadelphia, pp. 895-916.
2. Smithburn K. C. and Haddow A. J. (1944) Semliki Forest virus. I. Isolation and pathogenic properties. J. Immunol. 49, 141-147.
3. Taylor R. M., Hurlbut H. S., Work T. H., Kingsbury J. R., and Frothingham T. E. (1955) Sindbis virus: A newly recognized arthropod-transmitted virus. Am. J. Trop. Med. Hyg. 4, 844-846.
4. Kubes V. and Rios F. A. (1939) The causative agent of infectious equine encephalomyelitis in Venezuela. Science 90, 21.
5. Griffin D. E. (2001) Alphaviruses in Fields Virology. (Knipe D. M. and Howley P. M., eds.) Lippincott Williams & Wilkins, Philadelphia, pp. 917-962.
6. Bradish C. J., Allner K., and Maber H. B. (1971) The virulence of original and derived strains of Semliki Forest virus for mice, guinea pigs, and rabbits. J. Gen. Virol. 12, 141-160.
7. Fazakerley J. K., Pathak S., Scallan M., Amor S., and Dyson H. (1993) Replication of the A7(74) strain of Semliki Forest virus is restricted in neurons. Virology 195, 627-637.
8. Oliver K. R., Scallan M. F., Dyson H., and Fazakerley J. K. (1997) Susceptibility to a neurotropic virus and its changing distribution in the developing brain is a function of CNS maturity. J. Neurovirol. 3, 38-48.
9. Griffin D. E. (1998) A review of alphavirus replication in neurons. Neurosci. Biobehav. Rev. 22, 721-723.
10. Peränen J., Takkinen K., Kalkkinen N., and Kääriäinen L. (1988) Semliki Forest virus-specific non-structural protein nsP3 is a phosphoprotein. J. Gen. Virol. 69, 2165-2178.
11. LaStarza M. W., Lemm J. A., and Rice C. M. (1994) Genetic analysis of the nsP3 region of Sindbis virus: Evidence for roles in minus-strand and subgenomic RNA synthesis. J. Virol. 68, 5781-5791.
12. Davis N. L., Willis L. V., Smith J. F., and Johnston R. E. (1989) In vitro synthesis of infectious venezuelan equine encephalitis virus RNA from a cDNA clone: Analysis of a viable deletion mutant. Virology 171, 189-204.
13. Liljeström P. and Garoff H. (1991) A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. BioTechnology 9, 1356-1361.
14. Xiong C., Levis R., Shen P., Schlesinger S., Rice C. M., and Huang H. V. (1989) Sindbis virus: An efficient, broad host range vector for gene expression in animal cells. Science 243, 1188-1191.
15. Bredenbeek P. J., Frolov I., Rice C. M., and Schlesinger S. (1993) Sindbis virus expression vectors: Packaging of RNA replicons by using defective helper RNAs. J. Virol. 67, 6439-6446.
16. Lundstrom K. (1999) Alphaviruses as tools in neurobiology and gene therapy. J. Recept. Signal Transduct. Res. 19, 673-686.
17. Schlesinger S. (2001) Alphavirus vectors: Development and potential therapeutic applications. Expert Opin. Biol. Ther. 1, 177-191.
18. Hahn C. S., Hahn Y. S., Braciale T. J., and Rice C. M. (1992) Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation. Proc. Natl. Acad. Sci. USA 89, 2679-2683.
19. Malherbe P., Kratzeisen C., Lundstrom K., Richards J. G., Faull R. L. M., and Mutel V. (1999) Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Mol. Brain Res. 67, 201-210.
20. Polo J. M., Belli B. A., Driver D. A., et al. (1999) Stable alphavirus packaging cell lines for Sindbis virus and Semliki Forest virus-derived vectors. Proc. Natl. Acad. Sci. USA 96, 4598-4603.
21. Schlesinger S. (1993) Alphaviruses - Vectors for the expression of heterologous genes. Trends Biotechnol. 11, 18-22.
22. DiCiommo D. P. and Bremner R. (1998) Rapid, high level protein production using DNA-based Semliki Forest virus vectors. J. Biol. Chem. 273, 18,060-18,066.
23. Koller D., Ruedl C., Loetscher M., et al. (2001) A high-throughput alphavirus-based expression cloning system for mammalian cells. Nat. Biotechnol. 19, 851-855.
24. Atkins G. J., Sheahan B. J., and Liljeström P. (1999) The molecular pathogenesis of Semliki Forest virus: A model virus made useful? J. Gen. Virol. 80, 2287-2297.
25. Olkkonen V. M., Liljeström P., Garoff H., Simons K., and Dotti C. G. (1993) Expression of heterologous proteins in cultured rat hippocampal neurons using the Semliki Forest virus vector. J. Neurosci. Res. 35, 445-451.
26. Wittemann S., Mark M. D., Rettig J., and Herlitze S. (2000) Synaptic localization and presynaptic function of calcium channel β4-subunits in cultured hippocampal neurons. J. Biol. Chem. 275, 37,807-37,814.
27. Ehrengruber M. U., Lundstrom K., Schweitzer C., Heuss C., Schlesinger S., and Gähwiler B. H. (1999) Recombinant Semliki Forest virus and Sindbis virus efficiently infect neurons in hippocampal slice cultures. Proc. Natl. Acad. Sci. USA 96, 7041-7046.
28. Ehrengruber M. U., Hennou S., Büeler H., Naim H. Y., Déglon N., and Lundstrom K. (2001) Gene transfer into neurons from hippocampal slices: Comparison of recombinant Semliki Forest virus, adenovirus, adeno-associated virus, lentivirus, and measles virus. Mol. Cell. Neurosci. 17, 855-871.
29. Lundstrom K., Richards J. G., Pink J. R., and Jenck F. (1999) Efficient in vivo expression of a reporter gene in rat brain after injection of recombinant replication-deficient Semliki Forest virus. Gene Ther. Mol. Biol. 3, 15-23.
30. Gwag B. J., Kim E. Y., Ryu B. R., et al. (1998) A neuron-specific gene transfer by a recombinant defective Sindbis virus. Mol. Brain Res. 63, 53-61.
31. Osten P., Khatri L., Perez J. L., et al. (2000) Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor. Neuron 27, 313-325.
32. Maletic-Savatic M., Malinow R., and Svoboda K. (1999) Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science 283, 1923-1927.
33. Gähwiler B. H. (1981) Organotypic monolayer cultures of nervous tissue. J. Neurosci. Methods 4, 329-342.
34. Stoppini L., Buchs P.-A., and Muller D. (1991) A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182.
35. Malinow R., Hayashi Y., Maletic-Savatic M., Zaman S. H., Poncer J.-C., Shi S.-H., and Esteban J. A. (2000) Introduction of green fluorescent protein into hippocampal neurons through viral infection, in Imaging Neurons: A Laboratory Manual (Yuste R., Lanni F., and Konnerth A., eds.) CSHL Press, Cold Spring Harbor, pp. 58.1-58.8.
36. Ehrengruber M. U. and Lundstrom K. (2000) Alphavirus-mediated gene transfer into neurons, in Current Protocols in Neuroscience. (Crawley J. N., Gerfen C. R., Rogawski M. A., Sibley D. R., Skolnick P., and Wray S., eds.), John Wiley & Sons, New York, pp. 4.22.1-4.22.23.
37. Ehrengruber M. U. and Lundstrom K. (2002) Semliki Forest virus and Sindbis virus vectors, in Current Protocols in Human Genetics. (Dracopoli N. C., Haines J. L., Korf B. R., et al. eds.) John Wiley & Sons, New York, pp. 12.2.1-12.2.23.
38. Lundstrom K., Schweitzer C., Richards J. G., Ehrengruber M. U., Jenck E, and Mülhardt C. (1999) Semliki Forest virus vectors for in vitro and in vivo applications. Gene Ther. Mol. Biol. 4, 23-31.
39. Lundstrom K., Rotmann D., Hermann D., Schneider E. M., and Ehrengruber M. U. (2001) Novel mutant Semliki Forest virus vectors: Gene expression and localization studies in neuronal cells. Histochem. Cell Biol. 115, 83-91.
40. Shi S.-H., Hayashi Y., Petralia R. S., Zaman S. H., Wenthold R. J., Svoboda K., and Malinow R. (1999) Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284, 1811-1816.
41. Ehrengruber M. U., Muhlebach S. G., Söhrman S., Leutenegger C., M., Lester H. A., and Davidson N. (2000) Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus. Gene 258, 63-69.
42. B receptor directly interacts with the activating transcription factor 4. J. Biol. Chem. 275, 35,185-35,191.
43. Lundstrom K., Mills A., Buell G., Allet E., Adami N., and Liljeström P. (1994) High-level expression of the human neurokinin-1 receptor in mammalian cell lines using the Semliki Forest virus expression system. Eur. J. Biochem. 224, 917-921.
44. Monastyrskaia K., Lundstrom K., Plahl D., Acuna G., Schweitzer C., Malherbe P., and Mutel V. (1999) Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction. Br. J. Pharmacol. 128, 1027-1034.
45. Schweitzer C., Kratzeisen C., Adam G., et al. (2000) Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors. Neuropharmacology 39, 1700-1706.
46. Lundstrom K., Vargas A., and Allet B. (1995) Functional activity of a biotinylated human neurokinin 1 receptor fusion expressed in the Semliki Forest virus system. Biochem. Biophys. Res. Commun. 208, 260-266.
47. 1b-adrenergic receptor and G protein subunits in mammalian cell lines using the Semliki Forest virus expression system. J. Recept. Signal Transduct. Res. 19, 369-378.
48. A receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts. J. Neurosci. 17, 6587-6596.
49. Dryga S. A., Dryga O. A., and Schlesinger S. (1997) Identification of mutations in a Sindbis virus variant able to establish persistent infection in BHK cells: The importance of a mutation in the nsP2 gene. Virology 228, 74-83.
50. Agapov E. V., Frolov I., Lindenbach B. D., Pragai B. M., Schlesinger S., and Rice C. M. (1998) Non-cytopathogenic Sindbis RNA vectors for heterologous gene expression. Proc. Natl. Acad. Sci. USA 95, 12,989-12,994.
51. Perri S., Driver D. A., Gardner J. P., Sherrill S., Belli B. A., Dubensky T. W., Jr., and Polo J. M. (2000) Replicon vectors derived from Sindbis virus and Semliki Forest virus that establish persistent replication in host cells. J. Virol. 74, 9802-9807.
52. Rikkonen M. (1996) Functional significance of the nuclear-targeting and NTP-binding motifs of Semliki Forest virus nonstructural protein nsP2. Virology 218, 352-361.
53. Fazakerley J. K., Boyd A., Mikkola M. L., and Kääriäinen L. (2002) A single amino acid change in the nuclear localization sequence of the nsP2 protein affects the neurovirulence of Semliki Forest virus. J. Virol. 76, 392-396.
54. Mazzucchelli C., Vantaggiato C., Ciamei A., et al. (2002) Knockout of ERK1 MAP kinase enchances synaptic plasticity in the striatum and facilitates striatal-mediated lerning and memory. Neuron 34, 807-820.
55. Hahn Y. S., Grakoui A., Rice C. M., Strauss E. G., and Strauss J. H. (1989) Mapping of RNA-temperature-sensitive mutants of Sindbis virus: Complementation group F mutants have lesions in nsP4. J. Virol. 63, 1194-1202.
56. Hahn Y. S., Strauss E. G., and Strauss J. H. (1989) Mapping of RNA-temperature-sensitive mutants of Sindbis virus: Assignment of complementation groups A, B, and G to nonstructural proteins. J. Virol. 63, 3142-3150.
57. Boorsma M., Nieba L., Koller D., Bachmann M. F., Bailey J. E., and Renner W. A. (2000) A temperature-regulated replicon-based DNA expression system. Nature Biotech. 18, 429-432.
58. Lundstrom K., Ziltener P., Hermann D., Schweitzer C., Richards J. G., and Jenck F. (2001) Improved Semliki Forest virus vectors for receptor research and gene therapy. J. Recept. Signal Transduct. Res. 21, 55-70.
59. + channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proc. Natl. Acad. Sci. USA 94, 7070-7075.
60. Ehrengruber M. U., Ehler E., Billeter M. A., and Naim H. Y. (2002) Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. J. Virol. 76, 5720-5728.
61. Strauss J. H. and Strauss E. G. (1994) The alphaviruses: Gene expression, replication, and evolution. Microbiol. Rev. 58, 491-562.
62. Altman-Hamamdzic S., Groseclose C., Ma J.-X., Hamamdzic D., Vrindavanam N. S., Middaugh L. D., Parratto N. P., and Sallee E R. (1997) Expression of β-galactosidase in mouse brain: Utilization of a novel nonreplicative Sindbis virus vector as a neuronal gene delivery system. Gene Ther. 4, 815-822.
63. Knight D. E. (2000) Secreation from bovine chromaffin cells acutely expressing exogenous proteins using a recombinant Semliki Forest virus containing an EGFP reporter. Mol. Cell. Neurosci. 14, 486-505.
64. Allet B., Hochmann A., Martinoiu I., Berger A., Missotten M., Antonsson B., et al. (1996) Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis. J. Cell Biol. 135, 479-486.
65. Kyttälä A., Heinonen O., Peltonen L., and Jalanko A. (1998) Expression and endocytosis of lysosomal aspartylglucosaminidase in mouse primary neurons. J. Neurosci. 18, 7756.
66. Park D. S., Levine B., Ferrari G., and Greene L. A. (1997) Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons. J. Neurosci. 17, 8975-8983.
67. Hayashi Y., Shi S.-H., Esteban J. A., Piccini A., Poncer J.-C., and Malinow R. (2000) Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287, 2262-2267.
68. Voets T., Toonen R. F., Brian E. C., de Wit H., Moser T., Rettig J., Südhof T. C., Neher E., and Verhage M. (2001) Munc18-1 promotes large dense-core vesicle docking. Neuron 31, 581-591.
69. Ashery U., Varoqueaux F., Voets T., Betz A., Thakur P., Koch H., Neher E., Brose N., and Rettig J. (2000) Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells. EMBO J. 19, 3586-3596.
70. Chheda M. G., Ashery U., Thakur P., Rettig J., and Sheng Z. H. (2002) Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nat. Cell Biol. 3, 331-338.
71. Lao G., Scheuss V., Gerwin C. M., Su Q., Mochida S., Rettig J., and Sheng Z. H. (2000) Syntaphilin: A syntaxin-1 clamp that controls SNARE assembly. Neuron 25, 191-201.
72. A receptor α subunits expression with the properties of IPSCs in the developing thalamus. J. Neurosci. 20, 2202-2208.
73. Werner P., Kawashima E., Reid J., Hussy N., Lundstrom K., Buell G., Humbert Y., and Jones K. A. (1994) Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants. Mol. Brain Res. 26, 233-241.
74. 2-green fluorescent protein receptors. Proc. Natl. Acad. Sci. USA 98, 5288-5293.
75. Shi S.-H., Hayashi Y., Esteban J., and Malinow R. (2001) Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105, 331-343.
76. Zhu J. J., Esteban J. A., Hayashi Y., and Malinow R. (2000) Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity. Nat. Neurosci. 3, 1098-1106.
77. 2+-permeable AMPA receptors at hippocampal CA1 synapses and induction of NMDA receptor-independent long-term potentiation. Eur. J. Neurosci. 13, 1635-1643.
78. D-aspartate-induced α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pickl: Ligand-binding studies using Sindbis vectors carrying AMPA receptor decoys. J. Biol. Chem. 276, 40,025-40,032.
79. Takamori S., Rhee J. S., Rosenmund C., and Jahn R. (2001) Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). J. Neurosci. 21, RC182:1-6.
80. Takamori S., Rhee J. S., Rosenmund C., and Jahn R. (2000) Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Nature 407, 189-194.
81. Owe-Larsson B., Berglund M., Kristensson K., Garoff H., Larhammar D., and Low P. (1999) Perturbation of the synaptic release machinery in hippocampal neurons by overexpression of SNAP-25 with the Semliki Forest virus vector. Eur. J. Neurosci. 11, 1981-1987.
82. Wei S., Xu T., Ashery U., Kollewe A., Matti U., Antonin W., Rettig J., and Neher E. (2000) Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25. EMBO J. 19, 1279-1289.
83. Tobaben S., Thakur P., Fernandez-Chacon R., Südhof T. C., Rettig J., and Stahl B. (2001) A trimeric protein complex functions as a synaptic chaperone machine. Neuron 31, 687-699.
84. 2+ influx in Purkinje cells. Neuron 32, 113-122.
85. Simons M., De Strooper B., Multhaup G., Tienari P. J., Dotti C. G., and Beyreuther K. (2001) Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. J. Neurosci. 16, 899-908.
86. Cook D. G., Sung J. C., Golde T. E., et al. (1996) Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites. Proc. Natl. Acad. Sci. USA 93, 9223-9228.
87. Ulmanen I., Peranen J., Tenhunen J., Tilgmann C., Karhunen T., Panula P., Bernasconi L., Aubry J. P., and Lundstrom K. (1997) Expresion and intracellular localization of catechol O-methyltransferase in transfected mammalian cells. Eur. J. Biochem. 243, 452-459.
88. Hama E., Shirotani K., Masumoto H., Sekine-Aizawa Y., Aizawa H., and Saido T. C. (2001) Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons (Tokyo). J. Biochem 130, 721-726.
89. de Hoop M., von Poser C., Lange C., Ikonen E., Hunziker W., and Dotti C. G. (1995) Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture. J. Cell Biol. 130, 1447-1459.
90. Frolov I., Agapov E., Hoffman T. A., Prágai B. M., Lippa M., Schlesinger S., and Rice C. M. (1999) Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells. J. Virol. 73, 3854-3865.
91. Berglund P., Sjöberg M, Garoff H., et al. (1993) Semliki Forest virus expression system: Production of conditionally infectious recombinant particles. BioTechnology 11, 916-920.