c-Myc interacts with TRF1/PIN2 and regulates telomere length

Biochemical and Biophysical Research Communications

Volumn 362, Issue 4, 2007, Pages 842-847

  Kim, Hongtae ^a   Chen, Junjie ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Myc; Telomere; TRF1 PIN2

Indexed keywords

BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; DOUBLE STRANDED DNA; MYC PROTEIN; TELOMERASE; TELOMERIC REPEAT BINDING FACTOR 1;

ARTICLE; CONTROLLED STUDY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TELOMERE; TWO HYBRID SYSTEM; YEAST;

DNA-BINDING PROTEINS; HUMANS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 34548575232     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.08.064     Document Type: Article

References (23)

1. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
2. Blackburn E.H. Structure and function of telomeres. Nature 350 (1991) 569-573
3. Cervantes R.B., and Lundblad V. Mechanisms of chromosome-end protection. Curr. Opin. Cell Biol. 14 (2002) 351-356
4. de Lange T. Protection of mammalian telomeres. Oncogene 21 (2002) 532-540
5. Shen M., Haggblom C., Vogt M., Hunter T., and Lu K.P. Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. Proc. Natl. Acad. Sci. USA 94 (1997) 13618-13623
6. Kim S.H., Kaminker P., and Campisi J. TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23 (1999) 405-412
7. Smith S., Giriat I., Schmitt A., and de Lange T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282 (1998) 1484-1487
8. Iwano T., Tachibana M., Reth M., and Shinkai Y. Importance of TRF1 for functional telomere structure. J. Biol. Chem. 279 (2004) 1442-1448
9. Karlseder J., Kachatrian L., Takai H., Mercer K., Hingorani S., Jacks T., and de Lange T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell Biol. 23 (2003) 6533-6541
10. Gietz D., St Jean A., Woods R.A., and Schiestl R.H. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20 (1992) 1425
11. Hofer B., Backhaus S., and Timmis K.N. The biphenyl/polychlorinated biphenyl-degradation locus (bph) of Pseudomonas sp. LB400 encodes four additional metabolic enzymes. Gene 144 (1994) 9-16
12. Dang C.V. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell Biol. 19 (1999) 1-11
13. Grandori C., Cowley S.M., James L.P., and Eisenman R.N. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu. Rev. Cell Dev. Biol. 16 (2000) 653-699
14. Lutz W., Leon J., and Eilers M. Contributions of Myc to tumorigenesis. Biochim. Biophys. Acta 1602 (2002) 61-71
15. Mateyak M.K., Obaya A.J., Adachi S., and Sedivy J.M. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ. 8 (1997) 1039-1048
16. Knoepfler P.S., Cheng P.F., and Eisenman R.N. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 16 (2002) 2699-2712
17. Trumpp A., Refaeli Y., Oskarsson T., Gasser S., Murphy M., Martin G.R., and Bishop J.M. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414 (2001) 768-773
18. Wu K.J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., and Dalla-Favera R. Direct activation of TERT transcription by c-MYC. Nat. Genet. 21 (1999) 220-224
19. Greenberg R.A., O'Hagan R.C., Deng H., Xiao Q., Hann S.R., Adams R.R., Lichtsteiner S., Chin L., Morin G.B., and DePinho R.A. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 18 (1999) 1219-1226
20. Takakura M., Kyo S., Kanaya T., Hirano H., Takeda J., Yutsudo M., and Inoue M. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 59 (1999) 551-557
21. Dominguez-Sola D., Ying C.Y., Grandori C., Ruggiero L., Chen B., Li M., Galloway D.A., Gu W., Gautier J., and Dalla-Favera R. Non-transcriptional control of DNA replication by c-Myc. Nature 448 7152 (2007) 445-451
22. Smucker E.J., and Turchi J.J. TRF1 inhibits telomere C-strand DNA synthesis in vitro. Biochemistry 40 (2001) 2426-2432
23. Ohki R., and Ishikawa F. Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. Nucleic Acids Res. 32 (2004) 1627-1637