-
1
-
-
33644508373
-
Dihydrofolate reductase inhibitors as antibacterial agents
-
HAWSER S, LOCIURO S, ISLAM K: Dihydrofolate reductase inhibitors as antibacterial agents. Biochem. Pharmacol. (2006) 71:941-948.
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 941-948
-
-
HAWSER, S.1
LOCIURO, S.2
ISLAM, K.3
-
2
-
-
0242569143
-
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria
-
SCHNEIDER P, HAWSER S, ISLAM K: Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. Bioorg. Med. Chem. Lett. (2003) 13:4217-4221.
-
(2003)
Bioorg. Med. Chem. Lett
, vol.13
, pp. 4217-4221
-
-
SCHNEIDER, P.1
HAWSER, S.2
ISLAM, K.3
-
6
-
-
34848846419
-
Pharmacokinetics of single and multiple doses of iclaprim given by intravenous infusion in healthy volunteers
-
Niagara-On-The-Lake, Canada 9-11 October, Abstract P33
-
BRANDT R, IRONS S, MCBURNEY A et al.: Pharmacokinetics of single and multiple doses of iclaprim given by intravenous infusion in healthy volunteers. 3rd International Symposium on Resistant Gram-Positive Infections, Niagara-On-The-Lake, Canada (9-11 October 2006) (Abstract P33).
-
(2006)
3rd International Symposium on Resistant Gram-Positive Infections
-
-
BRANDT, R.1
IRONS, S.2
MCBURNEY, A.3
-
7
-
-
1942504486
-
AR-100, a novel diaminopyrimidine compound: Bactericidal activity and post-antibiotic effect on Gram-positive pathogens
-
San Diego, CA, USA 27-30 September, Abstract F-2029
-
HAWSER S, WEISS L, FISCHER M et al.: AR-100, a novel diaminopyrimidine compound: bactericidal activity and post-antibiotic effect on Gram-positive pathogens. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA (27-30 September 2002) (Abstract F-2029)
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
HAWSER, S.1
WEISS, L.2
FISCHER, M.3
-
8
-
-
34848848874
-
Pharmacodynamic activity of iclaprim vs. resistant Streptococcus pneumoniae using an in vitro model
-
Prague, Czech Republic 1-4 May, Abstract P1026
-
ZHANEL GG, GOOLIA M, RUSEN J et al.: Pharmacodynamic activity of iclaprim vs. resistant Streptococcus pneumoniae using an in vitro model. 14th European Congress of Clinical Microbiology and Infectious Diseases, Prague, Czech Republic (1-4 May 2004) (Abstract P1026).
-
(2004)
14th European Congress of Clinical Microbiology and Infectious Diseases
-
-
ZHANEL, G.G.1
GOOLIA, M.2
RUSEN, J.3
-
9
-
-
34848906090
-
-
ZHANEL GG, PALATNICK LP, HISNAGA TL et al.: Activity of iclaprim against penicillin, erythromycin, trimethoprim/sulfamethoxazole or ciprofloxacin-resistant Streptococcus pneumoniae from Canada. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA (14-17 September 2003): E2002.
-
ZHANEL GG, PALATNICK LP, HISNAGA TL et al.: Activity of iclaprim against penicillin, erythromycin, trimethoprim/sulfamethoxazole or ciprofloxacin-resistant Streptococcus pneumoniae from Canada. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA (14-17 September 2003): E2002.
-
-
-
-
10
-
-
1942536269
-
AR-100, a novel diaminopyrrimidine compound: Activity against selected Gram-positive and Gram-negative bacterial pathogens and synergy with other antibiotics
-
San Diego, USA 27-30 September, Abstract F-2019
-
HAWSER S, WEISS L, FISCHER M et al.: AR-100, a novel diaminopyrrimidine compound: activity against selected Gram-positive and Gram-negative bacterial pathogens and synergy with other antibiotics. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2019).
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
HAWSER, S.1
WEISS, L.2
FISCHER, M.3
-
11
-
-
34848890131
-
Iclaprim, a novel diaminopyrimidine antibiotic: Synergy studies with different classes of antibiotics
-
Prague, Czech Republic 1-4 May, Abstract P532
-
WEISS L, GILLESSEN D, HAWSER S et al.: Iclaprim, a novel diaminopyrimidine antibiotic: synergy studies with different classes of antibiotics. 14th European Congress of Clinical Microbiology and Infectious Diseases, Prague, Czech Republic (1-4 May 2004) (Abstract P532).
-
(2004)
14th European Congress of Clinical Microbiology and Infectious Diseases
-
-
WEISS, L.1
GILLESSEN, D.2
HAWSER, S.3
-
12
-
-
34848837177
-
Concentrations of iclaprim in plasma, epithelial lining fluid (Elf) alveolar macrophages (Am) and bronchial mucosa (Mb) following a single 1.6 mg/kg intravenous infusion in healthy subjects
-
Washington, DC, USA 16-19 December, Abstract
-
ANDREWS JM, HONEYBOURNE D, ASHBY JP et al.: Concentrations of iclaprim in plasma, epithelial lining fluid (Elf) alveolar macrophages (Am) and bronchial mucosa (Mb) following a single 1.6 mg/kg intravenous infusion in healthy subjects. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, USA (16-19 December 2005) (Abstract A-9).
-
(2005)
45th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
ANDREWS, J.M.1
HONEYBOURNE, D.2
ASHBY, J.P.3
-
14
-
-
1942504484
-
AR-100, a novel diaminopyrimidine: Activity against various clinical isolates of Gram-positive and Gram-negative bacteria
-
San Diego, USA , Abstract F-2022
-
GEMMELL CG, MIDDLEMAS G: AR-100, a novel diaminopyrimidine: activity against various clinical isolates of Gram-positive and Gram-negative bacteria. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy San Diego, USA (2002) (Abstract F-2022).
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
GEMMELL, C.G.1
MIDDLEMAS, G.2
-
15
-
-
1942504485
-
AR-100, a novel diaminopyrimidine compound: Activity against streptococci
-
San Diego, USA 27-30 September, Abstract F-2023
-
GOOD CE, WINDAU A, BAJAKSOUZIAN S et al.: AR-100, a novel diaminopyrimidine compound: activity against streptococci. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2023).
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
GOOD, C.E.1
WINDAU, A.2
BAJAKSOUZIAN, S.3
-
16
-
-
0242437814
-
Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at Hershey Medical Center
-
BOZDOGAN B, ESEL D, WHITENER C et al.: Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at Hershey Medical Center. J. Antimicrob. Chemother. (2003) 52:864-868.
-
(2003)
J. Antimicrob. Chemother
, vol.52
, pp. 864-868
-
-
BOZDOGAN, B.1
ESEL, D.2
WHITENER, C.3
-
17
-
-
9144264415
-
Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania
-
TENOVER FC, WEIGEL LM, APPELBAUM PC et al.: Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania. Antimicrob. Agents Chemother. (2004) 48:275-280.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 275-280
-
-
TENOVER, F.C.1
WEIGEL, L.M.2
APPELBAUM, P.C.3
-
18
-
-
1942536268
-
AR-100, a novel diaminopyrimidine compound: In vitro activity against pneumococci
-
San Diego, USA 27-30 September, Abstract F-2021
-
THEN RL, HARTMANN PG, LOCHER HH: AR-100, a novel diaminopyrimidine compound: in vitro activity against pneumococci. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2021).
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
THEN, R.L.1
HARTMANN, P.G.2
LOCHER, H.H.3
-
19
-
-
34848925907
-
-
MILATOVIC D, VERHOEF J, FLUIT AC: In vitro activity of iclaprim (AR-100) against Gram-positive and Gram-negative bacteria. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, USA (14-17 September 2003) (Abstract E-2006).
-
MILATOVIC D, VERHOEF J, FLUIT AC: In vitro activity of iclaprim (AR-100) against Gram-positive and Gram-negative bacteria. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, USA (14-17 September 2003) (Abstract E-2006).
-
-
-
-
20
-
-
1942440118
-
AR-100, a novel diaminopyrimidine compound: In vitro activity against Gram-positive and Gram-negative bacterial pathogens
-
San Diego, USA 27-30 September, Abstract F-2018
-
THEN RL, LOCHER HH, ANGEHRN P: AR-100, a novel diaminopyrimidine compound: in vitro activity against Gram-positive and Gram-negative bacterial pathogens. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2018).
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
THEN, R.L.1
LOCHER, H.H.2
ANGEHRN, P.3
-
21
-
-
34848813023
-
AR-100, a novel diaminopyrimidine compound: Activity against Haemophilus species and Moraxella catarrhalis
-
September, Abstract F-2026
-
JACOBS MR, WINDAU A, BAJAKSOUZIAN S et al.: AR-100, a novel diaminopyrimidine compound: activity against Haemophilus species and Moraxella catarrhalis. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2026).
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30
-
-
JACOBS, M.R.1
WINDAU, A.2
BAJAKSOUZIAN, S.3
-
23
-
-
1942536270
-
AR-100, a novel ciaminopyrimidine compound: Activity against enterobacteriaceae
-
San Diego, USA 27-30 September, Abstract F-2025
-
WINDAU A, BAJAKSOUZIAN S, APPELBAUM PC et al.: AR-100, a novel ciaminopyrimidine compound: activity against enterobacteriaceae. 42nd Intencience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2025).
-
(2002)
42nd Intencience Conference on Antimicrobial Agents and Chemotherapy
-
-
WINDAU, A.1
BAJAKSOUZIAN, S.2
APPELBAUM, P.C.3
-
24
-
-
1942504481
-
AR-100, a novel diaminopyrimidine compound: Anti-anaerobe activity compared to other agents
-
San Diego, USA 27-30 September, Abstract F-2027
-
EDNIE L, JACOBS M, APPELBAUM P: AR-100, a novel diaminopyrimidine compound: anti-anaerobe activity compared to other agents. 42nd Interscience Confirence on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2027).
-
(2002)
42nd Interscience Confirence on Antimicrobial Agents and Chemotherapy
-
-
EDNIE, L.1
JACOBS, M.2
APPELBAUM, P.3
-
25
-
-
2142646449
-
In vitro activity of a novel diaminopyrimidine comound, iclaprim, against Chlamydia trachomatis and C. pneumoniae
-
KOHLHOFF SA, ROBLIN PM, REZNIK T et al.: In vitro activity of a novel diaminopyrimidine comound, iclaprim, against Chlamydia trachomatis and C. pneumoniae. Antimicrob. Agents Chemother. (2004) 48:1885-1886.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 1885-1886
-
-
KOHLHOFF, S.A.1
ROBLIN, P.M.2
REZNIK, T.3
-
27
-
-
34848923191
-
Anti-pneumocystis activity of iclaprim, a reliable therapeutic alternative against pneumocystis pneumonia
-
Prague, Czech Republic 1-4 May, Abstract P533
-
ALIOUAT EM, DEI-CAS E, GANTOIS N et al.: Anti-pneumocystis activity of iclaprim, a reliable therapeutic alternative against pneumocystis pneumonia. 14th European Congress of Clinical Microbiology and Infectious Diseases, Prague, Czech Republic (1-4 May 2004) (Abstract P533).
-
(2004)
14th European Congress of Clinical Microbiology and Infectious Diseases
-
-
ALIOUAT, E.M.1
DEI-CAS, E.2
GANTOIS, N.3
-
28
-
-
33644507777
-
AR-100, a novel diaminopyrimidine compound: Resistance studies in trimethoprim-sensitive and -resistant
-
San Diego, USA 27-30 September, Abstract F-2028
-
HAWSER S, HALDIMANN A, PARISI S et al.: AR-100, a novel diaminopyrimidine compound: resistance studies in trimethoprim-sensitive and -resistant Staplylococcus aureus. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, USA (27-30 September 2002) (Abstract F-2028).
-
(2002)
Staplylococcus aureus. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
HAWSER, S.1
HALDIMANN, A.2
PARISI, S.3
-
29
-
-
33644525045
-
Efficacy and safety of intravenous iclaprim in complicated skin and skin structure infections: Results of a Phase II study
-
Washington, DC, USA , Abstract
-
KRIEVENS D, LEIGHTON A, BRANDT R et al.: Efficacy and safety of intravenous iclaprim in complicated skin and skin structure infections: results of a Phase II study. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, USA (2005) (Abstract L-1579).
-
(2005)
45th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
KRIEVENS, D.1
LEIGHTON, A.2
BRANDT, R.3
-
30
-
-
34848877924
-
In vitro plasma fibrin clot models versus in vivo models of experimental endocarditis: Case study for diaminopyrimidine antibiotics iclaprim and trimethoprim/ sulfamethoxazole
-
Prague, Czech Republic 1-4 May, Abstract P534
-
ENTENZA JM, GIDDEY M, VOUILLAMOZ J et al.: In vitro plasma fibrin clot models versus in vivo models of experimental endocarditis: case study for diaminopyrimidine antibiotics iclaprim and trimethoprim/ sulfamethoxazole. 14th European Congress of Clinical Microbiology and Infectious Diseases. Prague, Czech Republic (1-4 May 2004) (Abstract P534).
-
(2004)
14th European Congress of Clinical Microbiology and Infectious Diseases
-
-
ENTENZA, J.M.1
GIDDEY, M.2
VOUILLAMOZ, J.3
-
31
-
-
1942440119
-
AR-100, a novel diaminopyrimidine compound: In vivo efficacy in a murine model of staphylococcal septicemia
-
San Diego, USA 27-30 September, Abstract F-2030
-
CANDIANI GP, ROMANO G, JABES D et al.: AR-100, a novel diaminopyrimidine compound: in vivo efficacy in a murine model of staphylococcal septicemia. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2030).
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
CANDIANI, G.P.1
ROMANO, G.2
JABES, D.3
-
33
-
-
34247192001
-
The FDA and the case of Ketek
-
ROSS DB: The FDA and the case of Ketek. N. Engl. J. Med. (2007) 356:1601-1604.
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 1601-1604
-
-
ROSS, D.B.1
-
34
-
-
33847155159
-
Infectious diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults
-
MANDELL LA, WUNDERINK RG, ANZUETO A et al.: Infectious diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults. Clin. Infect. Dis. (2007) 44:S27-S72.
-
(2007)
Clin. Infect. Dis
, vol.44
-
-
MANDELL, L.A.1
WUNDERINK, R.G.2
ANZUETO, A.3
-
35
-
-
0000841123
-
Evidence that a point mutation in dihydrofolate reductasethymidylate synthase confers resistance to pyrimethamine in falciparum malaria
-
PETERSON DS, WALLIKER D, WELLEMS TE: Evidence that a point mutation in dihydrofolate reductasethymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc. Natl. Acad. Sci. USA (1988) 85:9114-9118.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 9114-9118
-
-
PETERSON, D.S.1
WALLIKER, D.2
WELLEMS, T.E.3
-
36
-
-
0027737510
-
Trimethoprim and brodimoprim resistance of Gram-positive and Gram-negative bacteria
-
THOMSON CJ: Trimethoprim and brodimoprim resistance of Gram-positive and Gram-negative bacteria. J. Chemother. (1993) 5:458-464.
-
(1993)
J. Chemother
, vol.5
, pp. 458-464
-
-
THOMSON, C.J.1
-
37
-
-
1942440120
-
AR-100, a novel diaminopyrimidine compund: Activity against staphylococci and enterococci
-
San Diego, USA 27-30 September, Abstract F-2024
-
BAJAKSOUZIAN S, WINDAU A, APPELBAUM PC et al.: AR-100, a novel diaminopyrimidine compund: activity against staphylococci and enterococci. 42nd Interscience Confirence on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract F-2024).
-
(2002)
42nd Interscience Confirence on Antimicrobial Agents and Chemotherapy
-
-
BAJAKSOUZIAN, S.1
WINDAU, A.2
APPELBAUM, P.C.3
-
38
-
-
34848885299
-
Iclaprim, a novel diaminopyrimidine antibiotic: In vitro and intracellular activitiy against Listeria monocytogenes
-
San Diego, USA 27-30 September, Abstract E-2004
-
FISCHER M, WEISS L, SCHEIDEGGER D et al.: Iclaprim, a novel diaminopyrimidine antibiotic: in vitro and intracellular activitiy against Listeria monocytogenes. 42nd Interscience Conftrence on Antimicrobial Agents and Chemotherapy, San Diego, USA (27-30 September 2002) (Abstract E-2004).
-
(2002)
42nd Interscience Conftrence on Antimicrobial Agents and Chemotherapy
-
-
FISCHER, M.1
WEISS, L.2
SCHEIDEGGER, D.3
|