Guanosine acts intracellularly to initiate apoptosis in NB4 cells: A role for nucleoside transport

Leukemia and Lymphoma

Volumn 48, Issue 9, 2007, Pages 1816-1827

  Flanagan, Sheryl A ^a   Gandhi, Varsha ^b   Meckling, Kelly A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Acute promyelocytic leukemia; Apoptosis; Csg; Guanosine; NB4

Indexed keywords

GUANOSINE; NUCLEOSIDE TRANSPORTER; NUCLEOSIDE TRANSPORTER CSG; PROTEIN BCL 2; PYRIMIDINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; INTRACELLULAR TRANSPORT; MITOCHONDRION; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; PROTEIN FUNCTION;

APOPTOSIS; BIOLOGICAL TRANSPORT; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DIPYRIDAMOLE; DNA; DNA FRAGMENTATION; GUANOSINE; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIMIDINES;

EID: 34548546785     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190701528491     Document Type: Article

References (50)

1. Brown, J. R., Cornell, K. and Cook, P. W. (2000) Adenosine- and adenine-nucleotide-mediated inhibition of normal and transformed keratinocyte proliferation is dependent upon dipyridamole-sensitive adenosine transport. J Invest Dermatol, 115, pp. 849-859.
2. Tanaka, Y., Yoshihara, K., Tsuyaki, M. and Kamiya, T. (1994) Apoptosis induced by adenosine in human leukemia HL-60 cells. Exp Cell Res, 213, pp. 242-252.
3. Dawicki, D. D., Chatterjee, D., Wych, J. and Rounds, S. (1997) Extracellular ATP and adenosine cause apoptosis of pulmonary artery endothelial cells. Am J Physiol, 273, pp. L484-L494.
4. Cabrita, M. A., Baldwin, S. A., Young, J. D. and Cass, C. E. (2002) Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes. Biochem Cell Biol, 80, pp. 623-638.
5. Plagemann, P GW, Wohlheuter, R. M. and Woffendin, C. (1988) Nucleoside and nucleobase transport in animal cells. Biochim Biophys Acta, 947, pp. 405-443.
6. Vijayalakshmi, D. and Belt, J. A. (1988) Sodium-dependent nucleoside transport in mouse intestinal epithelial cells. Two transport systems with differing substrate specificities. J Biol Chem, 263, pp. 19419-19423.
7. +-dependent, guanosine-specific nitrobenzylthioinosine-sensitive transporter in acute promyelocytic leukemia cells. J Biol Chem, 272, pp. 18026-18032.
8. +-dependent (cif) nucleoside transport in acute promyelocytic leukemia NB4 cells. J Cell Physiol, 166, pp. 593-600.
9. Flanagan, S. A. and Meckling, K. A. (2007) Nucleoside transporter expression and activity is regulated during granulocytic differentiation of NB4 cells in response to all-trans-retinoic acid. Leuk Res, 31, pp. 955-968.
10. Yazdanparast, R., Moosavi, M. A., Mahdavi, M. and Lotfi, A. (2006) Guanosine 5′-triphosphate induces differentiation-dependent apoptosis in human leukemia U937 and KG1 cells. Acta Pharmacol Sinica, 27, pp. 1175-1184.
11. Pilz, R. B., Huvar, I., Scheele, J. S., Berghe, G Van den and Boss, G. R. (1997) A decrease in the intracellular guanosine 5′-triphosphate concentration is necessary for granulocytic differentiation of HL-60 cells, but growth cessation and differentiation are not associated with a change in the activation state of Ras, the transforming principle of HL-60 cells. Cell Growth Differ, 8, pp. 53-59.
12. Wright, D. G. (1987) A role for guanine ribonucleotides in the regulation of myeloid cell maturation. Blood, 69, pp. 334-337.
13. Osti, F., Corradini, F. G., Hanau, S., Matteuzzi, M. and Gambari, R. (1997) Human leukemia K562 cells: Induction to erythroid differentiation by guanine, guanosine, and guanine nucleotides. Haematologica, 82, pp. 395-401.
14. Berry, D. M., Williams, K. and Meckling-Gill, K. A. (2000) All-trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor. Leuk Res, 24, pp. 307-316.
15. Martin, S. J. and Cotter, T. G. (1990) Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells. Cell Tissue Kinet, 23, pp. 545-559.
16. Rodriquez Jr, C. O., Plunkett, W., Paff, M. T., Min, D., Nowak, B. and Ramakrishna, P. (2000) High-performance liquid chromatography method for the determination and quantitation of arabinosylguanine triphosphate and fludarabine triphosphate in human cells. J Chromatogr, 745, pp. 421-430.
17. Sherman, P. A. and Fyfe, J. A. (1989) Enzymatic assay for deoxynucleoside triphosphates using synthetic oligonucleotides as template primers. Ann Biochem, 180, pp. 222-226.
18. Gandhi, V., Plunkett, W., Kantarjian, H., Talpaz, M., Roberston, L. E. and O'Brien, S. (1998) Cellular pharmacodynamics and plasma pharmacokinetics of parenterally infused hydroxyurea during a phase 1 clinical trial in chronic myelogenous leukemia. J Clin Oncol, 16, pp. 2321-2331.
19. Majno, G. and Joris, I. (1995) Apoptosis, oncosis, and necrosis: An overview of cell death. Am J Pathol, 146, pp. 3-16.
20. Kaufmann, S. H., Desnoyers, Y., Ottaviano, N. E., Davidson, N. E. and Poirier, G. G. (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res, 53, pp. 3976-3985.
21. Kaufmann, S. H. (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res, 49, pp. 5870-5878.
22. Lazenbik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. and Earnshaw, W. C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature, 371, pp. 346-347.
23. Kaufmann, S. H. and Earnshaw, W. C. (2000) Induction of apoptosis by cancer chemotherapy. Exp Cell Res, 256, pp. 42-49.
24. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K. and Gallant, M. (1995) Identification and inhibition of the ICE/ CED-3 protease necessary for mammalian apoptosis. Nature, 376, pp. 37-43.
25. Kim, K Tae, Yeo, E. -J., Choi, H. and Park, S. C. (1998) The effect of pyrimidine nucleosides on adenosine-induced apoptosis in HL-60 cells. J Cancer Res Clin Oncol, 124, pp. 471-477.
26. +)-dependent uridine-transport system. Involvement of protein kinase C. Biochem J, 274, pp. 85-90.
27. Lee, C. W. (1994) Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: Involvement of protein kinase C. Biochem J, 300, pp. 407-412.
28. Earnshaw, W. C., Martins, L. M. and Kaufmann, S. H. (1999) Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem, 68, pp. 383-424.
29. Vozza, A., Blanco, E., Palmier, L. and Palmier, F. (2004) Identification of the mitochondrial GTP/GDP transporter in Saccharomyces cerevisiae. J Biol Chem, 279, pp. 20850-20857.
30. Hakansson, P., Hofer, A. and Thelander, L. (2006) Regulation of mammalian ribonucleotide reduction and dNTP pools after dna damage and in resting cells. J Biol Chem, 281, pp. 7834-7841.
31. Kizaki, H., Shimada, H., Ohsaka, F. and Sakurada, T. (1988) Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes. J Immunol, 141, pp. 1652-1657.
32. Oliver, F. J., Marvel, J., Collines, M KL and Lopez-Rivas, A. (1993) Bcl-2 oncogene protects a bone marrow-derived pre-B-cell line from 5′-fluor,2′-deoxyuridine-induced apoptosis. Biochem Biophys Res Commun, 194, pp. 126-132.
33. Kwok, J BJ and Tattersall, M HN (1992) DNA fragmentation, dATP pool elevation and potentiaton of antifolate cytotoxicity in L1210 cells by hypoxanthine. Br J Cancer, 65, pp. 503-508.
34. Takebe, N., Cheng, X., Fandy, T. E., Srivastava, R. K. and Shankar, S. (2006) IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myelmoa cells. Mol Cancer Ther, 5, pp. 457-466.
35. Pressacco, J., Wiley, J. S., Jamieson, G. P., Enrlichman, C. and Hedley, D. W. (1995) Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis. Br J Cancer, 72, pp. 939-942.
36. Sidi, Y. and Mitchell, B. S. (1984) 2′-Deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulation. J Clin Invest, 74, pp. 1640-1648.
37. Martomo, S. A. and Mathews, C. K. (2002) Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitro. Mutat Res, 499, pp. 197-211.
38. Bebenek, K., Roberts, J. D. and Kunkel, T. A. (1992) The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. J Biol Chem, 268, pp. 3589-3596.
39. Traut, T. W. (1994) Physiological concentrations of purines and pyrimidines. Mol Cell Biochem, 140, pp. 1-22.
40. Gudkov, S. V., Shtarkman, I. N., Smirnova, V. S., Chernikov, A. V. and Bruskov, V. I. (2006) Guanosine and inosine display antioxidant activity, protect DNA in vitro from oxidative damage induced by reactive oxygen species, and serve as radioprotectors in mice. Radiat Res, 165, pp. 538-545.
41. Gandhi, V. and Plunkett, W. (1990) Modulatory activity of 2′,2′-difluorodeoxycytidine on the phoshorylation and cytotoxicity of arabinosylnucleosides. Cancer Res, 50, pp. 3675-3680.
42. Rauscher III, F. and Cadman, E. (1983) Biochemical and cytokinetic modulaiton of L1210 and Hl-60 cells by hydorxyurea and effect on 1-β-arabinofuranosylcytosine metabolism and cytotoxicity. Cancer Res, 43, pp. 2688-2693.
43. Horvath, Z., Saiko, P., Illmer, C., Madlener, S., Hoechtl, T. and Bauer, W. (2005) Synergistic action of resveratrol, an ingredient of wine, with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells. Exp Hematol, 33, pp. 329-335.
44. Cooper, T., Ayres, M., Nowak, B. and Gandhi, V. (2005) Biochemical modulation of cytarabine triphosphate by clofarabine. Cancer Chemother Pharmacol, 55, pp. 361-368.
45. Kim, S. G., Kim, C. W., Ahn, E. T., Lee, K. Y., Hong, E. K. and Yoo, B. I. (1997) Enhanced anti-tumour effects of acriflavine in combination with guanosine in mice. J Pharm Pharmacol, 49, pp. 216-222.
46. Kelly, K. J., Plotkin, Z. and Dagher, P. C. (2001) Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury. J Clin Invest, 108, pp. 1291-1298.
47. Pollock, J. L., Westervelt, P., Walter, M. J., Lane, A. A. and Ley, T. J. (2001) Mouse models of acute promyelocytic leukemia. Curr Opin Hematol, 8, pp. 206-211.
48. Moosavi, M. A., Yazdanparast, R. and Lotfi, A. (2006) GTP induces S-phase cell-cycle arrest and inhibits DNA synthesis in K562 cells but not in normal human periperal lymphocytes. J Biochem Mol Biol, 39, pp. 492-501.
49. Batiuk, T. D., Schnizlein-Bick, C., Plotkin, Z. and Dagher, P. C. (2001) Guanine nucleosides and Jurkat cell death: Roles of ATP depletion and accumulation of deoxyribonucleotides. Am J Physiol Cell Physiol, 281, pp. C1776-C1784.
50. Allay, J. A., Spencer, H. T., Wilkinson, S. L., Belt, J. A., Blakley, R. L. and Sorrentino, B. P. (1997) Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors. Blood, 90, pp. 3546-3554.