Enhanced anti-tumour effects of acriflavine in combination with guanosine in mice

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 2, 1997, Pages 216-222

  Kim, Sang Geon ^a   Kim, Choon Won ^b   Ahn, E Tay ^c   Lee, Kyung Yung ^d   Hong, Eun Kyung ^e   Yoo, Bo Im ^e   Han, Yung Bok ^e  

^a Duksung Women's University   (South Korea)

^b Hanyang University   (South Korea)

^c Soonchunhyang University   (South Korea)

^d Konkuk University School of Medicine   (South Korea)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACRIFLAVINE; ADENOSINE TRIPHOSPHATE; AG 60; GLUCOSE; GUANOSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG EFFICACY; DRUG POTENTIATION; EHRLICH ASCITES TUMOR; FLUORESCENCE MICROSCOPY; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; OSMOLARITY; SOLID TUMOR; TIME; TUMOR VOLUME;

EID: 0031059843     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06783.x     Document Type: Article

References (17)

1. Bose, S., Gothoskar, B. P., Ranadive, K. J. (1966) Studies of biological macromolecules: II. Effect of acriflavine exposure on the synthesis of macromolecules in liver cells in vivo. Exp. Cell Res. 42: 89-98
2. Canellakis, E. S., Chen, T.-K. (1979) Relationship of biochemical drug effects to their antitumor activity. I. Biochem. Pharmacol. 28: 1971-1976
3. Chakraborty, N. G., Bose, S. R. (1987) Protective immunity by chemically modified tumor cell antigens extracted by 3M KCl. Neoplasma 34: 427-430
4. Chakraborty, N. G., Bose, S. R., Chowdhury, J. (1980) Enhancement of immunogenicity of tumor cells by modification of cell surface with acridine dyes. Indian J. Exp. Biol. 18: 927-930
5. Chakraborty, N. G., Bose, S. R., Chowdhury, J. (1984) Acriflavine-induced surface changes in three tumor cell types and differential sensitivity to lectins. Tumori 70: 127-130
6. Corbett, T. H., Griswold, D. P., Roberts, B. J., Peckham, J. C., Schabel, F. M. (1977) Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas. Cancer 40: 2660-2680
7. Hannun, Y. A., Bell, R. M. (1988) Aminoacridines, potent inhibitors of protein kinase C. J. Biol. Chem. 263: 5124-5131
8. Iigo, M., Hoshi, A. (1984) Effect of guanosine on antitumor activity of fluorinated pyrimidines against P388 leukemia. Cancer Chemother. Pharmacol. 13: 86-90
9. Iigo, M., Miwa, M., Ishitsuka, H., Nitta, K. (1987) Potentiation of the chemotherapeutic action of 5′-deoxyfluorouridine in combination with guanosine and related compounds. Cancer Chemother. Pharmacol. 19: 61-64
10. Kohn, E. C., Liotta, L. A. (1995) Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55: 1856-1862
11. Macadam, R. F., Williamson, J. (1974) Drug effects on the fine structure of Trypanosoma rhodesiense: acriflavine, ethidium and antrycide. Ann. Trop. Med. Parasitol. 68: 291-299
12. Mathe, G., Pontiggia, P., Bourut, C., Chenu, E., Orbach-Arbouys, S. (1994) In vivo eradication of Friend virus as an experimental HIV-model, by combination of zidovudine, acriflavine and an ellipticine analogue. Possible application to the treatment of human pre-AIDS? Biomed. Pharmacother. 48: 51-53
13. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63
14. Roth, D., London, M., Manjon, M. (1967) Binding specificity and affinity of acriflavine for nucleic acids. Stain Tech. 42: 125-132
15. Santelli, G., Valeriote, F. (1978) In vivo enhancement of 5-fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice. J. Natl. Cancer Inst. 61: 843-847
16. Scholtissek, C., Becht, H. (1966) Action of acridines on RNA and protein synthesis and on active transport in chick embryo cells. Biochim. Biophys. Acta 123: 585-595
17. Tallarida, R. J., Murray, R. B. (1987) Manual of Pharmacologic Calculations with Computer Programs, Springer, New York.