Evidence for hypothalamic dysregulation in mouse models of anorexia as well as in humans

Physiology and Behavior

Volumn 92, Issue 1-2, 2007, Pages 278-282

  Johansen, Jeanette E ^a   Fetissov, Sergueï O ^b   Bergström, Ulrika ^c   Nilsson, Ida ^a   Faÿ, Charles ^a   Ranscht, Barbara ^c   Hökfelt, Tomas ^b   Schalling, Martin ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c BURNHAM INSTITUTE   (United States)

Author keywords

AgRP; Anorexia; Autoantibodies; Contactin; Hypothalamus; Mouse model; Neuropeptide Y; POMC

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; AUTOANTIBODY; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; CONTACTIN; MELANOCORTIN; NEUROPEPTIDE Y;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ANTIBODY DETECTION; ANX GENE; ARTICLE; BULIMIA; CONTROLLED STUDY; DISEASE MODEL; EATING DISORDER; ENERGY EXPENDITURE; FOOD INTAKE; GENE; GENE MUTATION; GENETIC LINKAGE; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS FUNCTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 34548528935     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2007.05.019     Document Type: Article

References (39)

1. Chronwall B.M. Anatomy and physiology of the neuroendocrine arcuate nucleus. Peptides 6 Suppl 2 (1985) 1-11
2. Everitt B.J., Meister B., Hökfelt T., Melander T., Terenius L., Rökaeus Å., et al. The hypothalamic arcuate nucleus-median eminence complex: immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons. Brain Res 396 (1986) 97-155
3. Hillebrand J.J., de Wied D., and Adan R.A. Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides 23 (2002) 2283-2306
4. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2002) 661-671
5. Fetissov S.O., and Hökfelt T. Autoimmune component in anorexia and bulimia nervosa. A new hypothesis for eating disorders. SSIB 11th Annual Meeting (2003) Groningen, The Netherlands
6. Fetissov S.O., Hallman J., Oreland L., af Klinteberg B., Grenbäck E., Hulting A.-L., et al. Autoantibodies against a-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients. Proc Natl Acad Sci USA 99 (2002) 17155-17160
7. Nilsson I., Johansen J.E., Schalling M., Hökfelt T., and Fetissov S.O. Maturation of the hypothalamic arcuate agouti-related protein system during postnatal development in the mouse. Dev Brain Res 155 (2005) 147-154
8. Grove K.L., and Smith M.S. Ontogeny of the hypothalamic neuropeptide Y system. Physiol Behav 79 (2003) 47-63
9. Maltais L.J., Lane P.W., and Beamer W.G. Anorexia, a recessive mutation causing starvation in preweanling mice. J Hered 75 (1984) 468-472
10. Johansen J.E., Teixeira V.L., Johansson C., Serrão P., Berggren P.-O., Soares-da-Silva P., et al. Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. NeuroReport 12 (2001) 2737-2741
11. Son J.H., Baker H., Park D.H., and Joh T.H. Drastic and selective hyperinnervation of central serotonergic neurons in a lethal neurodevelopmental mouse mutant, Anorexia (anx). Mol Brain Res 25 (1994) 129-134
12. Jahng J.W., Houpt T.A., Kim S.J., Joh T.H., and Son J.H. Neuropeptide Y mRNA and serotonin innervation in the arcuate nucleus of anorexia mutant mice. Brain Res 790 (1998) 67-73
13. Jahng J.W., Houpt T.A., Joh T.H., and Son J.H. Differential expression of monoamine oxidase A, serotonin transporter, tyrosine hydroxylase and norepinephrine transporter mRNA by anorexia mutation and food deprivation. Dev Brain Res 107 (1998) 241-246
14. Broberger C., Johansen J., Schalling M., and Hökfelt T. Hypothalamic neurohistochemistry of the murine anorexia (anx/anx) mutation: altered processing of neuropeptide Y in the arcuate nucleus. J Comp Neurol 387 (1997) 124-135
15. Broberger C., Johansen J., Johansson C., Schalling M., and Hökfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 95 (1998) 15043-15048
16. Broberger C., Johansen J., Brismar H., Johansson C., Schalling M., and Hökfelt T. Changes in pro-opiomelanocortin and of neuropeptide Y receptors in the anorexia (anx/anx) mouse hypothalamus. J Neurosci 19 (1999) 7130-7139
17. Johansen J.E., Broberger C., Lavebratt C., Johansson C., Kuhar M.J., Hökfelt T., et al. Hypothalamic CART and serum leptin levels are reduced in the anorectic (anx/anx) mouse. Mol Brain Res 84 (2000) 97-105
18. Cheung C.C., Thornton J.E., Kuijper J.L., Weigle D.S., Clifton D.K., and Steiner R.A. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 138 (1997) 855-858
19. Ahima R.S., Prabakaran D., and Flier J.S. Postnatal leptin surge and regulation of circadian rythm of leptin by feeding. J Clin Invest 101 (1998) 1020-1027
20. Bouret S.G., Draper S.J., and Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304 (2004) 108-110
21. Costa A., Poma A., Martignoni E., Nappi G., Ur E., and Grossman A. Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product leptin, from hypothalamic explants. Neuroreport 8 (1997) 1131-1134
22. Heiman M.L., Ahima R.S., Craft L.S., Schoner B., Stephens T.W., and Flier J.S. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 138 (1997) 3859-3863
23. Raber J., Chen S., Mucke L., and Feng L. Corticotropin-releasing factor and adrenocorticitrophic hormone as potential central mediators OB effects. J Biol Chem 272 (1997) 15057-15060
24. Devaskar S.U., Ollesch C., Rajakumar R.A., and Rajakumar P.A. Developmental changes in ob gene expression and circulating leptin peptide concentrations. Biochem Biophys Res Com 238 (1997) 44-47
25. Berglund E.O., Murai K.K., Fredette B., Sekerkova G., Marturano B., Weber L., et al. Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. Neuron 24 (1999) 739-750
26. Virgintino D., Ambrosini M., D'Errico P., Bertossi M., Papadaki C., Karagogeos D., et al. Regional distribution and cell type-specific expression of the mouse F3 axonal glycoprotein: a developmental study. J Comp Neurol 413 (1999) 357-372
27. + channels and increases their functional expression. J Neurosci 21 (2001) 7517-7525
28. Tessier-Lavigne M., and Goodman C.S. The molecular biology of axon guidance. Science 274 (1996) 1123-1133
29. Faivre-Sarrailh C., Gauthier F., Denisenko-Nehrbass N., Le Bivic A., Rougon G., and Girault J.A. The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (caspr). J Cell Biol 149 (2000) 491-502
30. Fetissov S.O., Bergström U., Johansen J.E., Hökfelt T., Ranscht B., and Schalling M. Alterations of arcuate nucleus neuropeptidergic development in Contactin-deficient mice: Comparison with anx/anx and food deprived mice. Eur J Neurosci 22 (2005) 3217-3228
31. Fetissov S.O., Harro J., Jaanisk M., Järv A., Podar I., Allik J., et al. Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Proc Natl Acad Sci USA 102 (2005) 14865-14870
32. De Wied D., and Jolles J. Neuropeptides derived from pro-opiocortin: behavioral, physiological, and neurochemical effects. Physiol Rev 62 (1982) 976-1059
33. Adan R.A., Szklarczyk A.W., Oosterom J., Brakkee J.H., Nijenhuis W.A., Schaaper W.M., et al. Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat. Eur J Pharmacol. 378 (1999) 249-258
34. Chaki S., Hirota S., Funakoshi T., Suzuki Y., Suetake S., Okubo T., et al. Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-m ethoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor. J Pharmacol Exp Ther 304 (2003) 818-826
35. Kishi T., and Elmquist J.K. Body weight is regulated by the brain: a link between feeding and emotion. Mol Psychiatry 10 (2005) 132-146
36. Byrne L.C., Zhou Z., Tryggvason K., Hökfelt T., and Fetissov S.O. Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice. NeuroReport 15 (2004) 569-574
37. Fetissov S.O. Autoimmune component in anorexia and bulimia nervosa. In: Fatemi S.H. (Ed). Neuropsychiatric Disorders and Infection (2004), Taylor & Francis Books Ltd, London 296
38. Whitney K.D., and McNamara J.O. Autoimmunity and neurological disease: antibody modulation of synaptic transmission. Annu Rev Neurosci 22 (1999) 175-195
39. Kowal C., DeGiorgio L.A., Nakaoka T., Hetherington H., Huerta P.T., Diamond B., et al. Cognition and immunity; antibody impairs memory. Immunity 21 (2004) 179-188