Learning during middle age: A resistance to stress?

Neurobiology of Aging

Volumn 28, Issue 11, 2007, Pages 1783-1788

  Hodes, Georgia E ^a   Shors, Tracey J ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Aging; Estrogen; Glucocorticoids; Learning; Sex differences; Trace conditioning

Indexed keywords

ADULTHOOD; AGE DISTRIBUTION; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; EYELID REFLEX; FEMALE; FISCHER 344 RAT; LEARNING; MALE; NONHUMAN; PRIORITY JOURNAL; PUBERTY; RAT; SEX DIFFERENCE; STRESS;

AGE FACTORS; AGING; ANIMALS; CONDITIONING, EYELID; FEMALE; LEARNING; MALE; RATS; RATS, INBRED F344; SEX CHARACTERISTICS; STRESS, PSYCHOLOGICAL;

EID: 34548527113     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.07.012     Document Type: Article

References (23)

1. Beylin A.V., and Shors T.J. Glucocorticoids are necessary for enhancing the acquisition of associative memories after acute stressful experience. Horm Behav 43 1 (2003) 124-131
2. Finkbiner R.G., and Woodruff-Pak D.S. Classical eyeblink conditioning in adulthood: effects of age and interstimulus interval on acquisition in the trace paradigm. Psychol Aging 6 1 (1991) 109-117
3. Hauger R.L., Thrivikraman K.V., and Plotsky P.M. Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats. Endocrinology 134 3 (1994) 1528-1536
4. Hodes G.E., and Shors T.J. Distinctive stress effects on learning during puberty. Horm Behav 48 2 (2005) 163-171
5. Issa A.M., Rowe W., Gauthier S., and Meaney M.J. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J Neurosci 10 10 (1990) 3247-3254
6. Knuttinen M.G., Gamelli A.E., Weiss C., Power J.M., and Disterhoft J.F. Age-related effects on eyeblink conditioning in the F344 × BN F1 hybrid rat. Neurobiol Aging 22 1 (2001) 1-8
7. Leuner B., and Shors T.J. Learning during motherhood: a resistance to stress. Horm Behav 50 1 (2006) 38-51
8. Lo M.J., Kau M.M., and Wang P.S. Effect of aging on corticosterone secretion in diestrous rats. J Cell Biochem 97 (2006) 351-358
9. Markowska A.L. Sex dimorphisms in the rate of age-related decline in spatial memory: relevance to alterations in the estrous cycle. J Neurosci 19 18 (1999) 8122-8133
10. Matt D.W., Sarver P.L., and Lu J.K. Relation of parity and estrous cyclicity to the biology of pregnancy in aging female rats. Biol Reprod 37 2 (1987) 421-430
11. McEchron M.D., Cheng A.Y., and Gilmartin M.R. Trace fear conditioning is reduced in the aging rat. Neurobiol Learn Mem 82 2 (2004) 71-76
12. Meites J. Changes in neuroendocrine control of anterior pituitary function during aging. Neuroendocrinology 34 (1982) 151-156
13. Romeo R.D., Lee S.J., Chhua N., McPherson C.R., and McEwen B.S. Testosterone cannot activate an adult-like stress response in prepubertal male rats. Neuroendocrinology 79 3 (2004) 125-132
14. Sapolsky R.M., Krey L.C., and McEwen B.S. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 7 3 (1986) 284-301
15. Shors T.J. Acute stress rapidly and persistently enhances memory formation in the male rat. Neurobiol Learn Mem 75 1 (2001) 10-29
16. Shors T.J., Lewczyk C., Pacynski M., Mathew P.R., and Pickett J. Stages of estrus mediate the stress-induced impairment of associative learning in the female rat. Neuroreport 9 3 (1998) 419-423
17. Shors T.J., and Miesegaes G. Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood. Proc Natl Acad Sci USA 99 21 (2002) 13955-13960
18. Vom Saal F.S., Finch C.E., and Nelson J.F. Natural history and mechanisms of reproductive aging in humans, laboratory rodents, and other selected vertebrates. In: Knobil E., and Neill J.D. (Eds). The physiology of reproduction. 2nd ed. vol. 2 (1994), Raven Press, New York 1215-1314
19. Wang C., Leung A., and Sinha Hikim A.P. Reproductive aging in the male brown-norway rat: a model for the human. Endocrinology 133 6 (1993) 2773-2781
20. Weiss C., and Thompson R.F. The effects of age on eyeblink conditioning in the freely moving Fischer-344 rat. Neurobiol Aging 12 3 (1991) 249-254
21. Wood G.E., and Shors T.J. Stress facilitates classical conditioning in males, but impairs classical conditioning in females through activational effects of ovarian hormones. Proc Natl Acad Sci USA 95 7 (1998) 4066-4071
22. Wood G.E., Beylin A.V., and Shors T.J. The contribution of adrenal and reproductive hormones to the opposing effects of stress on trace conditioning in males versus females. Behav Neurosci 115 1 (2001) 175-187
23. Woodruff-Pak D.S., Jaeger M.E., Gorman C., and Wesnes K.A. Relationships among age, conditioned stimulus-unconditioned stimulus interval, and neuropsychological test performance. Neuropsychology 13 1 (1999) 90-102