The 1.2 Å crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors

Structure

Volumn 7, Issue 1, 1999, Pages 55-63

  Usón, Isabel ^a   Sheldrick, George M ^a   De La Fortelle, Eric ^b   Bricogne, Gerard ^b,d   Di Marco, Stefania ^c,e   Priestle, John P ^c   Grütter, Markus G ^c,f   Mittl, Peer Re ^c,f  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

^d SYNCHROTRON SOLEIL   (France)

^e IRBM   (Italy)

^f UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Ab initio; Anticoagulant; Conformational flexibility; Maximum likelihood; Serine protease inhibitors; SIRAS

Indexed keywords

ANTISTASIN; DISULFIDE; HIRUSTASIN; KALLIKREIN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; HORMONE;

ARTICLE; BLOOD CLOTTING; LEECH; MAXIMUM LIKELIHOOD METHOD; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS; THROMBOSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; DRUG ANTAGONISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTICOAGULANTS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; FACTOR XA; INVERTEBRATE HORMONES; LEECHES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS;

EID: 34548519838     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(99)80009-4     Document Type: Article

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