Mistletoe extracts (Viscum album L.) Iscador® interact with the cell cycle machinery and target survival mechanisms in cancer cells

Medicina

Volumn 67, Issue SUPPL. 2, 2007, Pages 79-84

  Ramaekers, Frans C S ^a,b   Harmsma, Marjan ^a   Tusenius, Karel J ^c   Schutte, Bert ^b   Werner, Michael ^d   Ramos, Mac ^e  

^a MUbio Products BV   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c Medical Centre Berg en Bosch   (Netherlands)

^d Verein fur Krebsforschung   (Switzerland)

^e WELEDA AG   (Germany)

Author keywords

Apoptotic pathways; Carcinomas; Caspases; Cell cycle; Endothelial cells; Iscador; Lymphomas

Indexed keywords

BROXURIDINE; CASPASE 3; CASPASE 8; CYTOCHROME C; DEATH RECEPTOR; LECTIN; LIPOCORTIN 5; PROPIDIUM IODIDE; VISCUM ALBUM EXTRACT;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL SURVIVAL; COLORECTAL CARCINOMA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOCHEMISTRY; CYTOTOXICITY; DRUG DOSAGE FORM COMPARISON; DRUG SENSITIVITY; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME ACTIVITY; EPIDERMIS CELL; HUMAN; HUMAN CELL; HYPOTHESIS; IMMUNOMODULATION; IN VIVO STUDY; INCUBATION TIME; LYMPHOMA CELL; MICROTUBULE; MITOCHONDRION; MOLECULAR MECHANICS; SIGNAL TRANSDUCTION; SPINDLE CELL; TUMOR GROWTH; TUMOR NECROSIS; TUMOR REGRESSION; VISCUM ALBUM;

EID: 34548489890     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Folkman J. and Shing Y. Angiogenesis. J Biol Chem 1992; 267: 10931-4.
2. van Engeland M, et al. A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry 1996; 24: 131-9.
3. Lauber K, et al. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 2003; 113: 717-30.
4. Kaufmann SH, Hengartner MO. Programmed cell death: alive and well in the new millennium. Trends Cell Biol 2001; 11: 526-34.
5. Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res 2003; 63: 2705-15.
6. Leers MP, Kölgen W, Björklund V, et al. Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol 1999; 187: 567-72.
7. Harmsma M, Ummelen M, Dignef W, Tusenius KJ, Ramaekers F.C.S. Effects of mistletoe (Viscum album L.) extracts Iscador on cell cycle and survival of tumor cells. Arzneimittelforschung/Drug Research 56(6A) 2006; 474-82.
8. Begg A C, et al. A method to measure the duration of DNA synthesis and the potential doubling time from a single sample. Cytometry 1985; 6: 620-6.
9. Higashikubo R, RA White, et al. Flow cytometric BrdUrd-pulse-chase study of heat-induced cell-cycle progression delays. Cell Prolif 1993; 26: 337-48.
10. Boukamp P, RT Petrussevska, et al. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988; 106: 761-7.
11. Harmsma M, Gromme M, Ummelen M, Dignef W, Tusenius KJ, Ramaekers F.C.S. Differential effects of Viscum album extract Iscador®Qu on cell cycle progression and apoptosis in cancer cells. Int J Oncol 2004; 25:1521-9.