Amphiphilic dendrimeric peptides as model non-sequential pharmacophores with antimicrobial properties

Journal of Molecular Microbiology and Biotechnology

Volumn 13, Issue 4, 2007, Pages 220-225

  Janiszewska, Jolanta ^a   Urbanczyk Lipkowska, Zofia ^b  

^a POLISH ACADEMY OF SCIENCES   (Poland)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Poland)

Author keywords

Antibacterial peptides; Dendrimeric peptides; Non sequential pharmacophore

Indexed keywords

DENDRIMER;

ANTIMICROBIAL ACTIVITY; CANDIDA ALBICANS; CONFERENCE PAPER; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PHARMACOPHORE; STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CANDIDA ALBICANS; DENDRIMERS; ESCHERICHIA COLI; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS;

CANDIDA ALBICANS; ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

EID: 34548483920     PISSN: 14641801     EISSN: None     Source Type: Journal    
DOI: 10.1159/000104751     Document Type: Conference Paper

References (15)

1. Lequin O, Bruston F, Convert O, Chassaing G, Nicolas P: Helical structure of dermaseptin B2 in a membrane-mimetic environment. Biochemistry 2003;42:10311-10323.
2. Papo N, Shai Y: Exploring peptide membrane interaction using surface plasmon resonance: differentiation between pore formation versus membrane disruption by lytic peptides. Biochemistry 2003;42:458-466.
3. Powers JPS, Hancock REW: The relationship between peptide structure and antibacterial activity. Peptides 2003;24:1681-1691.
4. Misselwitz B, Schmidt-Willich H, Ebert W, Frenzel T, Weinmann HJ: Pharmacokinetics of gadomer-17, a new dendritic magnetic resonance contrast agent. Magn Res Mater Phys Biol Med 2001;B12:128-134.
5. Ramshaw JAH, Werkmeister, JA, Glattauer V: Collagen-based biomaterials. Biotechnol Genet Eng Rev 1996;13:335-382.
6. Witvrouw M, Fikkert V, Pluymers W, Matthews B, Mardel K, Schols D, Raff J, Debyser Z, De Clercq E, Holan G, Pannecouque C: Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle. Mol Pharmacol 2000;58:1100-1108.
7. Ben-Yedidia T, Arnon R: Design of peptide and polypeptide vaccines. Curr Opin Biotechnol 1997;8:442-448.
8. Dufe C, Uchegbu IF, Schatzlein AG: Dendrimers in gene delivery. Adv Drug Deliv Rev 2005;57:2177-2202.
9. Janiszewska J, Switon J, Lipkowski AW, Urbanczyk-Lipkowska Z: Low molecular mass peptide dendrimers that express antimicrobial properties. Bioorg Med Chem Lett 2003;13:3711-3713.
10. Klajnert B, Janiszewska J, Urbanczyk-Lipkowska Z, Bryszewska M, Epand RM: DSC studies on interactions between low molecular mass peptide dendrimers and model lipid membranes. Int J Pharm 2006;327:145-152.
11. Simmaco M, Mignogna G, Barra D: Antimicrobial peptides from amphibian skin: What do they tell us? Biopolymers 1998;47:435-450.
12. Chen CZ, Cooper SL: Interactions between dendrimer biocides and bacterial membranes. Biomaterials 2002;23:3359-3368.
13. Tam JP: Recent advances in multiple antigen peptides. J Immunol Methods 1996;196:17-32.
14. Tam JP, Lu Y-A, Yang J-L: Antimicrobial dendrimeric peptides. Eur J Biochem 2002;269:923-932.
15. Klajnert B, Janiszewska J, Urbanczyk-Lipkowska Z, Bryszewska M, Shcharbin D, Labieniec M: Biological properties of low molecular mass peptide dendrimers. Int J Pharm 2006;309:208-217.