Thyroid-Stimulating Hormone Suppression for Protection Against Hypothyroidism Due to Craniospinal Irradiation for Childhood Medulloblastoma/Primitive Neuroectodermal Tumor

International Journal of Radiation Oncology Biology Physics

Volumn 69, Issue 2, 2007, Pages 404-410

  Massimino, Maura ^a   Gandola, Lorenza ^a   Collini, Paola ^a   Seregni, Ettore ^a   Marchianò, Alfonso ^a   Serra, Annalisa ^a   Pignoli, Emanuele ^a   Spreafico, Filippo ^a   Pallotti, Federica ^a   Terenziani, Monica ^a   Biassoni, Veronica ^a   Bombardieri, Emilio ^a   Fossati Bellani, Franca ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Childhood brain tumors; Craniospinal irradiation; Iatrogenic hypothyroidism; Thyroid protection

Indexed keywords

DOSIMETRY; IRRADIATION; ONCOLOGY; RADIOTHERAPY; TUMORS;

CHILDHOOD BRAIN TUMORS; CRANIOSPINAL IRRADIATION; IATROGENIC HYPOTHYROIDISM; THYROID PROTECTION;

HORMONES;

CARBOPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; LEVOTHYROXINE; LIOTHYRONINE; LOMUSTINE; METHOTREXATE; THIOTEPA; THYROTROPIN; VINCRISTINE;

ADOLESCENT; ADULT; ARTICLE; BRAIN TUMOR; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG MEGADOSE; FOLLOW UP; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HUMAN; HYPOTHYROIDISM; IRRADIATION; MEDULLOBLASTOMA; MULTIMODALITY CANCER THERAPY; NEUROECTODERM TUMOR; PRIORITY JOURNAL; RADIATION DOSE; THYROID FUNCTION; TREATMENT OUTCOME; ULTRASOUND;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; CRANIAL IRRADIATION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; HYPOTHYROIDISM; INFANT; MALE; MEDULLOBLASTOMA; NEUROECTODERMAL TUMORS, PRIMITIVE; RADIOTHERAPY DOSAGE; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 34548473371     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.03.028     Document Type: Article

References (24)

1. Oberfield S.E., Allen J.C., Pollack J.M., et al. Long-term endocrine sequelae after treatment of medulloblastoma: Prospective study of growth and thyroid function. J Pediatr 108 (1986) 219-223
2. Paulino A.C. Hypothyroidism in children with medulloblastoma: A comparison of 3600 and 2340 cGy craniospinal radiotherapy. Int J Radiat Oncol Biol Phys 53 (2002) 543-547
3. Gharib H., James E.M., Charboneau J.W., et al. Suppressive therapy with levothyroxine for solitary thyroid nodules. A double blind controlled clinical study. N Engl J Med 317 (1987) 70-75
4. Wemeau J.L., Caron P., Schvartz C., et al. Effects of thyroid-stimulating hormone suppression with levothyroxine in reducing the volume of solitary thyroid nodules and improving extranodular nonpalpable changes: A randomized, double-blind, placebo-controlled trial by the French Thyroid Research Group. J Clin Endocrinol Metab 87 (2002) 4928-4934
5. Crile G., Antunez A.R., Esseltyn C.B., et al. The advantages of subtotal thyroidectomy and suppression of TSH in the primary treatment of papillary carcinoma of the thyroid. Cancer 55 (1985) 2691-2697
6. Kaplan E.L., and Meier P. Non parametric estimation from incomplete observation. J Am Stat Assoc 53 (1958) 457-481
7. Cox R. Regression models and life tables. J Royal Stat Soc 34 (1972) 187-202
8. Massimino M., Gandola L., Spreafico F., et al. Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy. Int J Radiat Oncol Biol Phys 64 (2006) 1031-1037
9. Spreafico F., Massimino M., Gandola L., et al. Survival of adults treated for medulloblastoma using paediatric protocols. Eur J Cancer 41 (2005) 1304-1310
10. Ron E., Lubin J.H., Shore R.E., et al. Thyroid cancer after exposure to external radiation: A pooled analysis of seven studies. Radiat Res 141 (1995) 259-277
11. Shalet S.M., Rosenstock J.D., Beardwell C.G., et al. Thyroid dysfunction following external radiation to the neck for Hodgkin's disease in childhood. Clin Radiol 28 (1977) 511-515
12. Hancock S.L., McDougall I.R., and Constine L.S. Thyroid abnormalities after therapeutic external irradiation. Int J Radiat Oncol Biol Phys 31 (1995) 1165-1170
13. Constine L.S., Donaldson S.S., McDougall I.R., et al. Thyroid dysfunction after radiotherapy in children with Hodgkin's disease. Cancer 53 (1984) 878-883
14. Van Santen H.M., Vulsma T., Dijkgraaf M.G., et al. No damaging effect of chemotherapy in addition to radiotherapy on the thyroid axis in young adult survivors of childhood cancer. J Clin Endocrinol Metab 88 (2003) 3657-3663
15. Ricardi U., Corrias A., Einaudi S., et al. Thyroid dysfunction as a late effect in childhood medulloblastoma: A comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. Int J Radiat Oncol Biol Phys 50 (2001) 1287-1294
16. Chin D., Sklar C., Donahue B., et al. Thyroid dysfunction as a late effect in survivors of pediatric medulloblastoma/primitive neuroectodermal tumors. Cancer 80 (1997) 798-804
17. Van Santen H.M., Van Dijk J.E., Rodermond H., et al. The effect of cervical X-irradiation on activity index of thyrocytes and plasma TSH: A pre-clinical model for radiation-induced thyroid damage. J Endocrinol Invest 28 (2005) 261-269
18. Surks M.I., and Sievert R. Drugs and thyroid function. N Engl J Med 333 (1995) 1688-1694
19. Goldberg R.C., Lindsay S., and Feller D.D. Histopathological changes induced in the normal thyroid and other tissues of the rat by internal radiation with various doses of radioactive iodine. Endocrinology 46 (1950) 72-90
20. Nishiyama K., Tanaka E., Tarui Y., et al. A prospective analysis of subacute thyroid dysfunction after neck irradiation. Int J Radiat Oncol Biol Phys 34 (1996) 439-444
21. Van Santen H.M., Thonissen N.M., De Kraker J., et al. Changes in thyroid hormone state in children receiving chemotherapy. Clin Endocrinol 62 (2005) 250-257
22. Mulhern R.K., and Palmer S.L. Neurocognitive late effects in pediatric cancer. Curr Probl Cancer 27 (2003) 177-197
23. Zelmanovitz F., Genro S., and Gross J.L. Suppressive therapy with levothyroxine for solitary thyroid nodules: A double-blind controlled clinical study and cumulative meta-analyses. J Clin Endocrinol Metab 83 (1998) 3881-3885
24. Van Santen H.M., Rodermond H., van Dijk J., et al. Prevention of thyroid damage due to radiotherapy in the treatment of childhood malignancies: A rat model. [Abstract]. Med Pediatr Oncol 37 (2001) 303