Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 64, Issue 4, 2006, Pages 1031-1037

  Massimino, Maura ^a   Gandola, Lorenza ^a   Spreafico, Filippo ^a   Luksch, Roberto ^a   Collini, Paola ^a   Giangaspero, Felice ^c   Simonetti, Fabio ^a   Casanova, Michela ^a   Cefalo, Graziella ^a   Pignoli, Emanuele ^a   Ferrari, Andrea ^a   Terenziani, Monica ^a   Podda, Marta ^a   Meazza, Cristina ^a   Polastri, Daniela ^a   Poggi, Geraldina ^b   Ravagnani, Fernando ^a   Fossati Bellani, Franca ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b SCIENTIFIC INSTITUTE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Childhood brain tumors; HART; High dose chemotherapy; S PNET

Indexed keywords

CHEMOTHERAPY; DRUG DOSAGE; PATIENT TREATMENT; RADIOTHERAPY;

CHILDHOOD BRAIN TUMORS; HART; HIGH-DOSE CHEMOTHERAPY; S-PNET;

TUMORS;

AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; CARBOPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; FOLINIC ACID; GRANULOCYTE COLONY STIMULATING FACTOR; LIVER ENZYME; LOMUSTINE; METHOTREXATE; OPIATE; THIOTEPA; VINCRISTINE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BACTEREMIA; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER SURGERY; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM METASTASIS; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE INTERVAL; DISEASE FREE SURVIVAL; DRUG MEGADOSE; ENCEPHALITIS; FEBRILE NEUTROPENIA; FEMALE; GLIOBLASTOMA; GRAM NEGATIVE INFECTION; HERPES SIMPLEX ENCEPHALITIS; HUMAN; IRRADIATION; MALE; METASTASIS; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; NEUROECTODERM TUMOR; NEUROSURGERY; NEUTROPENIA; PINEAL BODY TUMOR; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RADIATION DOSE FRACTIONATION; SEPSIS; SKULL; SPINE; SURVIVAL RATE; THROMBOCYTOPENIA; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR LOCALIZATION;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CHEMOTHERAPY, ADJUVANT; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CYCLOPHOSPHAMIDE; DOSE FRACTIONATION; ETOPOSIDE; FEMALE; HUMANS; LOMUSTINE; MALE; METHOTREXATE; NEUROECTODERMAL TUMORS, PRIMITIVE; PROSPECTIVE STUDIES; STEM CELL TRANSPLANTATION; SUPRATENTORIAL NEOPLASMS; SURVIVAL ANALYSIS; THIOTEPA; TREATMENT OUTCOME; VINCRISTINE;

EID: 33644545710     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2005.09.026     Document Type: Article

References (34)

1. M.N. Hart, K.M. Earle Primitive neuroectodermal tumors of the brain in children Cancer 32 1973 890 897
2. M.E. Burnett, E.C. While, S. Sih Chromosome arm 17 p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system Cancer Genet Cytogenet 97 1997 25 31
3. C. Russo, M. Pellarin, O. Tingby Comparative genomic hybridization in patients with supratentorial and infratentorial primitive neuroectodermal tumors Cancer 86 1999 331 339
4. E.C. Halperin, H.S. Friedman, S.C. Schold Surgery, hyperfractionated craniospinal irradiation, and adjuvant chemotherapy in the management of supratentorial embryonal neuroepithelial neoplasms in children Surg Neurol 40 1993 278 283
5. B. Timmermann, R.D. Kortmann, J. Kühl Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood Results of the prospective German Brain Tumor Trial HIT 88/89 and 91 J Clin Oncol 20 2002 842 849
6. S. Gururangan, C. McLaughin, J. Quinn High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastoma J Clin Oncol 21 2003 2187 2191
7. A. Pérez-Martinez, V. Quinterno, M. Gonzalez Vicent High-dose chemotherapy with autologous stem-cell rescue as first line of treatment in young children with medulloblastoma and supratentorial primitive neuroectodermal tumors J Neurooncol 71 2005 33 38
8. M.D. Prados, W. Wara, M.S.B. Edwards Treatment of high-risk medulloblastoma and other primitive neuroectodermal tumors with reduced dose craniospinal radiation therapy and multi-agent nitroso-urea-based chemotherapy Pediatr Neurosurg 25 1996 174 181
9. K. Dhodapkar, I.J. Dunkel, S. Gradner Preliminary results of dose intensive pre-irradiation chemotherapy in patients older than 10 years of age with high risk medulloblastoma and supratentorial primitive neuroectodermal tumors Med Pediatr Oncol 38 2002 47 48
10. D. Stroher, D. Ashley, S.J. Kellie Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy Results of a collaborative study J Clin Oncol 19 2001 2696 2704
11. M. Massimino, L. Gandola, R. Luksch Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma Neuro-Oncol 7 2005 41 48
12. A.C. Gnekow SIOP Brain Tumor Subcommittee. International Society of Pediatric Oncology Recommendations of the Brain Tumor Subcommittee for the reporting of trials Med Pediatr Oncol 24 1995 104 108
13. E.L. Kaplan, P. Meier Nonparametric estimation from incomplete observation J Am Stat Assoc 53 1958 457 481
14. R. Peto, J. Peto Asymptomatically efficient rank invariant test procedures J R Stat Soc [A] 135 1972 185 207
15. R. Cox Regression models and life tables J Royal Stat Soc 34 1972 187 202
16. J.R. Geyer, P.M. Zeltzer, J.M. Boyett Survival of infants with primitive neuroectodermal tumors of malignant ependymoma of the CNS treated with eight drugs in 1 day A report from the Children's Cancer Group J Clin Oncol 12 1994 1607 1615
17. R.I. Jakacki, P.M. Zeltzer, J.M. Boyett Survival and prognostic factors following radiation and/or chemotherapy for primitive neuroectodermal tumors of the pineal region in infants and children A report of the Children's Cancer Group J Clin Oncol 13 1995 1377 1383
18. P. Marec-Berard, A. Jouvet, P. Thiesse Supratentorial embryonal tumors in children under 5 years of age An SFOP study of treatment with postoperative chemotherapy alone Med Pediatr Oncol 38 2002 83 90
19. B.H. Cohen, P.M. Zeltzer, J.M. Boyett Prognostic factors and treatment results for supratentorial primitive neuroectodermal tumors in children using radiation and chemotherapy A Children's Cancer Group randomised trial J Clin Oncol 13 1995 1687 1696
20. Y. Mikaeloff, M.A. Raquin, A. Lellouch-Tubiana Primitive cerebral neuroectodermal tumors excluding medulloblastomas A retrospective study of 30 cases Pediatr Neurosurg 29 1998 170 177
21. P.K. Duffner, M.E. Cohen, R.A. Sanford Lack of efficacy of postoperative chemotherapy and delayed radiation in very young children with pineoblastoma Med Pediatr Oncol 25 1995 38 44
22. A.C. Paulino, E. Melina Medulloblastoma and supratentorial primitive neuroectodermal tumors Cancer 86 1999 142 148
23. P.B. Dirks, L. Harris, H.J. Hoffman Supratentorial primitive neuroectodermal tumors in children J Neuro-Oncol 29 1996 75 84
24. F. Spreafico, M. Massimino, L. Gandola Survival of adults treated for medulloblastoma using pediatric protocols Eur J Cancer 41 2005 1304 1310
25. L. Gandola, G. Cefalo, M. Massimino Hyperfractionated accelerated radiotherapy (HART) after intensive postoperative sequential chemotherapy for metastatic medulloblastoma [Abstract] Med Pediatr Oncol 39 2002 248
26. W.P. Mason, A. Grovas, S. Halperin Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors J Clin Oncol 16 1988 212 222
27. D.M. Ashley, D. Longeve, R. Tien Treatment of patients with pineoblastoma with high dose cyclophosphamide Med Pediatr Oncol 26 1996 387 392
28. A.L. Albright, J.H. Wisoff, P. Zeltzer Prognostic factors in children with supratentorial (nonpineal) primitive neuroectodermal tumors Pediatr Neurosurg 22 1995 1 7
29. H.J. Yang, D.H. Nam, K.C. Wang Supratentorial primitive neuroectodermal tumor in children Clinical features, treatment outcome and prognostic features Child's Nerv Syst 15 1999 377 383
30. A.T. Reddy, A.J. Janss, P.C. Phillips Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation and chemotherapy Cancer 88 2000 2189 2193
31. A.C. Paulino, D.T. Cha, J.L. Barker Patterns of failure in relation to radiotherapy fields in supratentorial primitive neuroectodermal tumor Int J Radiat Oncol Biol Phys 58 2004 1171 1176
32. T.S. Hong, M.P. Mehta, J.M. Boyett Patterns of failure in supratentorial primitive neuroectodermal tumors treated in Children's Cancer Group Study 921, a phase III combined modality study Int J Radiat Oncol Biol Phys 60 2004 204 213
33. A. Broniscer, T.P. Nicolaides, I.J. Dunkel High-dose chemotherapy with autologous stem-cell rescue in the treatment of patients with recurrent non-cerebellar primitive neuroectodermal tumors Pediatr Blood Cancer 42 2004 261 267
34. I. Moroni, M. Bugiani, L. D'Incerti L-2-hydroxyglutaric aciduria and brain malignant tumors A predisposing condition? Neurology 62 2004 1882 1884