Presenting features of 201 children with acute lymphoblastic leukemia: Comparison according to presence or absence of ETV6/RUNX1 rearrangement

Cancer Genetics and Cytogenetics

Volumn 177, Issue 2, 2007, Pages 161-163

  Alvarez, Yolanda ^a   Caballin M R ^a   Gaitan S ^a   Perez A ^a   Bastida, P ^b   Ortega, J J ^b   Cervera, J ^c   Verdeguer, A ^c   Tasso, M ^d   Aventin A ^e   Badell, I ^f   Guitart, M ^g   Melo, M ^g   Granada, I ^h   Javier, G ^h   Dastugue, N ⁱ   Robert, A ⁱ   Coll, M D ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c Universitidad de Valencia   (Spain)

^d HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^e HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^f St Cross and St Paul Hospital   (Spain)

^g Pediatrics Service   (Spain)

^h CATALAN INSTITUTE OF ONCOLOGY   (Spain)

ⁱ HÔPITAL DES ENFANTS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1;

ACUTE LYMPHOBLASTIC LEUKEMIA; B LYMPHOCYTE; CANCER INCIDENCE; CHILD; CHROMOSOME TRANSLOCATION 1; CLINICAL FEATURE; CLINICAL PROTOCOL; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; LETTER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; T LYMPHOCYTE;

CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 21; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; ONCOGENE PROTEINS, FUSION; PROGNOSIS; SURVIVAL RATE; TRANSLOCATION, GENETIC;

EID: 34548472421     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2007.05.012     Document Type: Letter

References (16)

1. Romana S.P., Poirel H., Le Coniat M., Flexor M.A., Mauchauffe M., Jonveaux P., Berger R., and Bernard O.A. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Leukemia 86 (1995) 4263-4269
2. Rubnitz J.E., Downing J.R., Pui C.H., Shurtleff S.A., Raimondi S.C., Evans W.E., Head D.R., Crist W.M., Rivera G.K., Hancock M.L., Boyett J.M., Buijs A., Grosveld G., and Behm F.G. TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognosis significance. J Clin Oncol 15 (1997) 1150-1157
3. Borkhardt A., Cazzaniga G., Viehmann S., Valsecchi M.G., Ludwig W.D., Burci L., Mangioni S., Schrappe M., Riehm H., Lampert F., Basso G., Masera G., Harbott J., and Biondi A. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicentre therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group. Blood 90 (1997) 571-577
4. Loh M.L., Silverman L.B., Young M.L., Neuberg D., Golub T.R., Sallan S.E., and Gilliland D.G. Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia. Blood 92 (1998) 4792-4797
5. Maloney K.W., McGavran L., Murphy J.R., Odom L.F., Stork L., Wei Q., and Hunger S.P. TEL/AML1 fusion identifies a subset of children with standard risk acute lymphoblastic leukemia who have an excellent prognosis when treated with therapy that includes a single delayed intensification. Leukemia 13 (1999) 1708-1712
6. Konrad M., Metzler M., Panzer S., Östreicher I., Peham M., Repp R., Haas O.A., Gadner H., and Panzer-Grümayer E.R. Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the persistence of a preleukemic clone. Blood 101 (2003) 3635-3640
7. Loh M.L., and Rubnitz J.E. TEL/AML1 positive pediatric leukemia: prognostic significance and therapeutic approaches. Curr Opin Hematol 9 (2002) 345-352
8. Alvarez Y., Coll M.D., Ortega J.J., Bastida P., Dastugue N., Robert A., Cervera J., Verdeguer A., Tasso M., Aventín A., Guitart M., and Caballín M.R. Genetic abnormalities associated with the t(12;21) translocation and their impact in the outcome of 56 patients with B-precursor acute lymphoblastic leukemia. Cancer Genet Cytogenet 162 (2005) 21-29
9. Vilmer E., Suciu S., Ferster A., Bertrand Y., Cave H., Thyss A., Benoit Y., Dastugue N., Fournier M., Souillet G., Manel A.M., Robert A., Nelken B., Millot F., Lutz P., Rialland X., Mechinaud F., Boutard P., Behar C., Chantraine J.M., Plouvier E., Laureys G., Brock P., Uyttebroeck A., Margueritte G., Plantaz D., Norton L., Francotte N., Gyselinck J., Waterkeyn C., Solbu G., Philippe N., and Otten J. Long-term results of randomized trials (58831, 58832, 58881) in childhood acute lymphoblastic leukemia: A CLCG-EORTC report. Children Leukemia Cooperative group. Leukemia 14 (2000) 2257-2266
10. Ribera J.M., Ortega J.J., Oriol A., Bastida P., Calvo C., Perez-Hurtado J.M., Gonzalez-Valentin M.E., Martin-Reina V., Molines A., Ortega-Rivas F., Moreno M.J., Rivas C., Egurbide I., Heras I., Poderos C., Martinez-Revuelta E., Guinea J.M., del Potro E., and Deben G. Comparison of intensive chemotherapy, allogeneic, or autologous stem-cell transplantation as postremission treatment for children with very high risk acute lymphoblastic leukemia: PETHEMA ALL-93 trial. J Clin Oncol 25 (2007) 16-24
11. Douet-Guilbert N., Morel F., Le Bris M.J., Herry A., Le Calvez G., Marion V., Abgrall J.F., Berthou C., and De Braekeleer M. A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984-2001). Cancer Genet Cytogenet 144 (2003) 143-147
12. Attarbaschi A., Mann G., Konig M., Dworzak M.N., Trebo M.M., Muhlegger N., Gadner H., and Haas O.A. Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis. Leukemia 18 (2004) 1611-1616
13. García-Sanz R., Alaejos I., Orfão A., Rasillo A., Chillón M.C., Tabernero M.D., Mateos M.V., López-Pérez R., González D., Balanzategui A., González M., San Miguel J.F., and Bortolucci A. Low frequency of TEL/AML1 fusion gene in acute lymphoblastic leukaemia in Spain. Br J Haematol 107 (1999) 667-669 [Erratum in: Br J Haematol 2000;110:245]
14. Martínez-Ramírez A., Urioste M., Contra T., Cantalejo A., Tavares A., Portero J.A., López-Ibor B., Bernacer M., Soto C., Cigudosa J.C., and Benítez J. Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes: correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia. Haematologica 86 (2001) 1245-1253
15. Yeoh E.J., Ross M.E., Shurtleff S.A., Williams W.K., Patel D., Mahfouz R., Behm F.G., Raimondi S.C., Relling M.V., Patel A., Cheng C., Campana D., Wilkins D., Zhou X., Li J., Liu H., Pui C.H., Evans W.E., Naeve C., Wong L., and Downing J.R. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1 (2002) 133-143
16. Alvarez Y., Coll M.D., Bastida P., Ortega J.J., and Caballín M.R. AML1 amplification in a child with acute lymphoblastic leukemia. Cancer Genet Cytogenet 140 (2003) 58-61