Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 9, 2007, Pages 1287-1295

  Toklu, Hale Z ^a   Dumlu, Melek U ^a   Sehirli, Özer ^a   Ercan, Feriha ^a   Gedik, Nursal ^b   Gökmen, Vural ^c   Sener, Goksel ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b KASIMPASA MILITARY HOSPITAL   (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLLAGEN; GLUTATHIONE; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; MALONALDEHYDE; MYELOPEROXIDASE; PLANT EXTRACT; PUNICA GRANATUM EXTRACT; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT LIGATION; BILE DUCT OBSTRUCTION; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVITY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER FIBROSIS; LIVER FUNCTION; LIVER STRUCTURE; MALE; NONHUMAN; POMEGRANATE; RAT; TISSUE INJURY;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BILE DUCTS; COLLAGEN; DISEASE MODELS, ANIMAL; GLUTATHIONE; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; LIGATION; LIVER CIRRHOSIS; LUMINESCENCE; MALE; MALONDIALDEHYDE; PEROXIDASE; PHYTOTHERAPY; PLANT EXTRACTS; PUNICACEAE; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548455462     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.9.0014     Document Type: Article

References (35)

1. Adams, L. S., Seeram, N. P., Aggarwal, B. B., Takada, Y., Sand, D., Heber, D. (2006) Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J. Agricult. Food Chem. 54: 980-985
2. Ahmed, S., Wang, N., Hafeez, B. B., Cheruvu, V. K., Haqqi, T. M. (2005) Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro. J. Nutr. 135: 2096-2102
3. Beuge, J. A., Aust, S. D. (1978) Microsomal lipid peroxidation. Methods Enzymol. 52: 302-311
4. Beutler, E. (1975) Glutathione in red blood cell metabolism. In: E. Beutler, (ed) A manual of biochemical methods. Grune and Stratton, New York, pp 112-114
5. Chidambara Murthy, K. N., Jayaprakasha, G. K., Singh, R. P. (2002) Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J. Agricult. Food Chem. 50: 4791-4795
6. Davies, G. R., Simmonds, N. J., Stevens, T. R., Sheaff, M. T., Banatvala, N., Laurenson, I. F., Blake D. R., Rampton, D. S. (1994) Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 35: 179-185
7. Di Carlo, G., Mascolo, N., Izzo, A. A., Capasso, F. (1999) Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sci. 65: 337-353
8. Dumlu, M. U., Gurkan, E. (2006) A new active compound from Centaurea species. Z. Naturforsch. 61: 44-46
9. Fernandez-Martinez, E., Perez-Alvarez, V., Tsutsumi, V., Shibayama, M., Muriel, P. (2006) Chronic bile duct obstruction induces changes in plasma and hepatic levels of cytokines and nitric oxide in the rat. Exp. Toxicol. Pathol. 58: 49-58
10. Friedman, S. L. (2003) Liver fibrosis - from bench to bedside. J. Hepatol. 38: S38-S53
11. Gil, M. I, Tomas-Barberan, F. A., Hess-Pierce, B., Holcroft, D. M., Kader, A. A. (2000) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agricult. Food Chem. 48: 4581-4589
12. Guo, S., Deng, Q., Xiao, J., Xie, B., Sun, Z. (2007) Evaluation of antioxidant activity and preventing DNA damage effect of pomegranate extracts by chemiluminescence method. J. Agricult. Food Chem. 55: 3134-3140
13. Hillegass, L. M., Griswold, D. E., Brickson, B., Albrightson-Winslow, C. (1990) Assessment of myeloperoxidase activity in whole rat kidney. J. Pharmacol. Methods 24: 285-295
14. Huang, Y. T., Hsu, Y. C., Chen, C. J., Liu, C. T., Wei, Y. H. (2003) Oxidative-stress-related changes in the livers of bile-duct-ligated rats. J. Biomed. Sci. 10: 170-178
15. Jeong, D. H., Lee, G. P., Jeong, W. I., Do, S. H., Yang, H. J., Yuan, D. W., Park, H. Y., Kim, K. J., Jeong, K. S. (2005) Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis. W. J. Gastroenterol. 11: 1141-1148
16. Kullak-Ublick, G. A., Meier, P. J. (2000) Mechanisms of cholestasis. Clin. Liver Dis. 4: 357-385
17. Liu, T. Z., Lee, K. T., Chern, C. L., Cheng, J. T., Stern, A., Tsai, L. Y. (2001) Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB. Ann. Clin. Lab. Sci. 31: 383-390
18. Lopez De Leon, A., Rojkind, M. (1985) A simple micromethod for collagen and total protein determination in formalin-fixed parraffin-embedded sections. J. Histochem. Cytochem. 33: 737-743
19. Martinek, R. G. (1972) A rapid ultraviolent spectrophotomeetric lactic dehydrogenase assay. Clin. Chim. Acta 40: 91-99
20. Moss, D. W., Henderson, A. R., Kachmar, J. F. (1987) Enzymes. In: Tietz N. W. (ed) Fundamentals of clinical chemistry, WB Saunders, Philadelphia, pp 372-373
21. Muriel, P., Moreno, M. G. (2004) Effects of silymarin and vitamins E and C on liver damage induced by prolonged biliary obstruction in the rat. Basic Clin. Pharmacol. Toxicol. 94: 99-104
22. Nan, J. X., Park, E. J., Kim, H. J., Ko, G., Sohn, D. H. (2000) Antifibrotic effects of the methanol extract of Polygonum aviculare in fibrotic rats induced by bile duct ligation and scission. Biol. Pharm. Bull. 23: 240-243
23. Ohta, Y., Kongo, M., Kishikawa, T. (2003) Therapeutic effect of melatonin on cholestatic liver injury in rats with bile duct ligation. Adv. Exp. Med. Biol. 527: 559-565
24. Padillo, F. J., Muntane, J., Montero, J. L., Briceno, J., Mino, G., Solorzano, G., Sitges-Serra, A., Pera-Madrazo, C. (2002) Effect of internal biliary drainage on plasma levels of endotoxin, cytokines, and C-reactive protein in patients with obstructive jaundice. World J. Surg. 26: 1328-1332
25. Peres, W., Tunon, M. J., Collado, P. S., Herrmann, S., Marroni, N., Gonzalez-Gallego, J. (2000) The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction. J. Hepatol. 33: 742-750
26. Poyrazoglu, E. S., Gokmen, V., Artik, N. (2002) Organic acids and phenolic compounds in pomegranates (Punica granatum L.) grown in Turkey. J. Food Compos. Anal. 15: 567-575
27. Ross, D. (1988) Glutathione, free radicals and chemotherapeutic agents. Pharmacol. Ther. 37: 231-249
28. Sener, G., Kabasakal, L., Sehirli, O., Ercan, F., Gedik, N. (2006) 2-Mercaptoethane sulfonate (MESNA) protects against biliary obstruction-induced oxidative damage in rats. Hepatol. Res. 35: 140-146
29. Sener, G., Sehirli, A. O., Toklu, H. Z., Yuksel, M., Ercan, F., Gedik, N. (2007) Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction. Pediatr. Surg. Int. 23: 233-241
30. Shimizu, I., Ma, Y. R., Mizobuchi, Y., Liu, F., Miura, T., Nakai, Y., Yasuda, M., Shiba, M., Horie, T., Amagaya, S., Kawada, N., Hori, H., Ito, S. (1999) Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology 29: 149-160
31. Simpson, K. J., Lukacs N. W., Colletti, L., Strieter, R. M., Kunkel, SL. (1997) Cytokines and the liver. J. Hepatol. 27: 1120-1132
32. Singh, R. P., Chidambara Murthy, K. N., Jayaprakasha, G. K. (2002) Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J. Agricult. Food Chem. 50: 81-86
33. Tilg, H., Wilmer, A., Vogel, W., Herold, M., Nolchen, B., Judmaier, G., Huber, C. (1992) Serum levels of cytokines in chronic liver diseases. Gastroenterology 10: 264-274
34. Vidal, A., Fallarero, A., Pena, B. R., Medina, M. E., Gra, B., Rivera, F., Gutierrez, Y., Vuorela, P. M. (2003) Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol. 89: 295-300
35. Zhong, Z., Froh, M., Lehnert, M., Schoonhoven, R., Yang, L., Lind, H., Lemasters, J. J., Thurman, L. G. (2003) Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am. J. Physiol., Gastrointest. Liver Physiol 285: G1004-G1013