Reduced central blood volume and cardiac output and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 3, 2007, Pages

  Stewart, Julian M ^a   Taneja, Indu ^a   Medow, Marvin S ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Exercise intolerance; Mechanoreflex; Metaboreflex; Orthostatic intolerance; Regional blood volume

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BLOOD VOLUME; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HAND GRIP; HEART OUTPUT; HEART RATE VARIABILITY; HUMAN; IMPEDANCE PLETHYSMOGRAPHY; MALE; POSTURAL TACHYCARDIA SYNDROME; PRIORITY JOURNAL; STATIC EXERCISE; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; VASCULAR RESISTANCE; VEIN OCCLUSION PLETHYSMOGRAPHY;

ADULT; BAROREFLEX; BLOOD PRESSURE; BLOOD VOLUME; CARDIAC OUTPUT, LOW; CASE-CONTROL STUDIES; DIZZINESS; EXERCISE; EXERCISE TOLERANCE; FEMALE; HAND STRENGTH; HEART RATE; HUMANS; MALE; MUSCLE FATIGUE; MUSCLE, SKELETAL; POSTURE; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM; SYNDROME; TACHYCARDIA; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 34548444628     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00439.2007     Document Type: Article

References (70)

1. Ansorge EJ, Augustyniak RA, Perinot ML, Hammond RL, Kim JK, Sala-Mercado JA, Rodriguez J, Rossi NF, O'Leary DS. Altered muscle metaboreflex control of coronary blood flow and ventricular function in heart failure. Am J Physiol Heart Circ Physiol 288: H1381-H1388, 2005.
2. Augustyniak RA, Collins HL, Ansorge EJ, Rossi NF, O'Leary DS. Severe exercise alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 280: H1645-H1652, 2001.
3. Bloomfield DA. Dye Curves: the Theory and Practice of Indicator Dye Dilution. Baltimore, MD: University Park, 1974.
4. Bonyhay I, Freeman R. Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome. Ann Neurol 61: 332-339, 2007.
5. Cornett JA, Herr MD, Gray KS, Smith MB, Yang QX, Sinoway LI. Ischemic exercise and the muscle metaboreflex. J Appl Physiol 89: 1432-1436, 2000.
6. Crisafulli A, Salis E, Tocco F, Melis F, Milia R, Pittau G, Caria MA, Solinas R, Meloni L, Pagliaro P, Concu A. Impaired central hemodynamic response and exaggerated vasoconstriction during muscle metaboreflex activation in heart failure patients. Am J Physiol Heart Circ Physiol 292: H2988-H2996, 2007.
7. Crisafulli A, Scott AC, Wensel R, Davos CH, Francis DP, Pagliaro P, Coats AJ, Concu A, Piepoli MF. Muscle metaboreflex-induced increases in stroke volume. Med Sci Sports Exerc 35: 221-228, 2003.
8. Eldridge FL, Millhorn DE, Kiley JP, Waldrop TG. Stimulation by central command of locomotion, respiration and circulation during exercise. Respir Physiol 59: 313-337, 1985.
9. Farquhar WB, Taylor JA, Darling SE, Chase KP, Freeman R. Abnormal baroreflex responses in patients with idiopathic orthostatic intolerance. Circulation 102: 3086-3091, 2000.
10. Furlan R, Jacob G, Snell M, Robertson D, Porta A, Harris P, Mosqueda-Garcia R. Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control. Circulation 98: 2154-2159, 1998.
11. Geddes LA, Baker LE. Detection of physiological events by impedance. In: Principles of Applied Biomedical Instrumentation. New York: Wiley, 1989, p. 594-600.
12. Geddes LA, Sadler C. The specific resistance of blood at body temperature. Med Biol Eng 11: 336-339, 1973.
13. Gladwell VF, Fletcher J, Patel N, Elvidge LJ, Lloyd D, Chowdhary S, Coote JH. The influence of small fibre muscle mechanoreceptors on the cardiac vagus in humans. J Physiol 567: 713-721, 2005.
14. Greenfield AD, Whitney RJ, Whitney RJ. Methods for the investigation of peripheral blood flow. Br Med Bull 19: 101-109, 1963.
15. Hammond RL, Augustyniak RA, Rossi NF, Churchill PC, Lapanowski K, O'Leary DS. Heart failure alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 278: H818-H828, 2000.
16. Harms MP, van Lieshout JJ. Cerebrovascular and cardiovascular responses associated with orthostatic intolerance and tachycardia. Clin Auton Res 11: 35-38, 2001.
17. He YL, Tanigami H, Ueyama H, Mashimo T, Yoshiya I. Measurement of blood volume using indocyanine green measured with pulse- spectrophotometry: its reproducibility and reliability. Crit Care Med 26: 1446-1451, 1998.
18. Iellamo F, Pizzinelli P, Massaro M, Raimondi G, Peruzzi G, Legramante JM. Muscle metaboreflex contribution to sinus node regulation during static exercise: insights from spectral analysis of heart rate variability. Circulation 100: 27-32, 1999.
19. Iijima T, Aoyagi T, Iwao Y, Masuda J, Fuse M, Kobayashi N, Sankawa H. Cardiac output and circulating blood volume analysis by pulse dye-densitometry. J Clin Monit 13: 81-89, 1997.
20. Jacob G, Costa F, Shannon JR, Robertson RM, Wathen M, Stein M, Biaggioni I, Ertl A, Black B, Robertson D. The neuropathic postural tachycardia syndrome. N Engl J Med 343: 1008-1014, 2000.
21. Jordan J, Shannon JR, Diedrich A, Black BK, Robertson D. Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity. Hypertension 39: 173-178, 2002.
22. Karas B, Grubb BP, Boehm K, Kip K. The postural orthostatic tachycardia syndrome: a potentially treatable cause of chronic fatigue, exercise intolerance, and cognitive impairment in adolescents. Pacing Clin Electrophysiol 23: 344-351, 2000.
23. Kaufman MP. Has the phoenix risen? J Physiol 548: 666, 2003.
24. Kaufman MP, Forster HV. Reflexes controlling circulatory, ventilatory and airway responses to exercise. In: Handbook of Physiology, edited by Rowell LB, Shepherd JT. New York: Oxford Univ. Press, 1996, p. 381-447.
25. Kaufman MP, Rybicki KJ. Discharge properties of group III and IV muscle afferents: their responses to mechanical and metabolic stimuli. Circ Res 61: I60-I65, 1987.
26. Kim JK, Sala-Mercado JA, Hammond RL, Rodriguez J, Scislo TJ, O'Leary DS. Attenuated arterial baroreflex buffering of muscle metaboreflex in heart failure. Am J Physiol Heart Circ Physiol 289: H2416-H2423, 2005.
27. Kim JK, Sala-Mercado JA, Rodriguez J, Scislo TJ, O'Leary DS. Arterial baroreflex alters strength and mechanisms of muscle metaboreflex during dynamic exercise. Am J Physiol Heart Circ Physiol 288: H1374-H1380, 2005.
28. Kluess HA, Wood RH, Welsch MA. Vagal modulation of the heart and central hemodynamics during handgrip exercise. Am J Physiol Heart Circ Physiol 278: H1648-H1652, 2000.
29. Low PA, Opfer-Gehrking TL, Textor SC, Benarroch EE, Shen WK, Schondorf R, Suarez GA, Rummans TA. Postural tachycardia syndrome (POTS). Neurology 45: S19-S25, 1995.
30. Mancia G, Mark AL. Arterial baroreflexes in humans. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow, edited by Shepherd JT, Abboud FM, Geiger SR. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 2, chapt. 20, p. 755-793.
31. Mancia G, Parati G, Castiglioni P, di Rienzo M. Effect of sinoaortic denervation on frequency-domain estimates of baroreflex sensitivity in conscious cats. Am J Physiol Heart Circ Physiol 276: H1987-H1993, 1999.
32. McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol 224: 173-186, 1972.
33. Medow MS, Minson CT, Stewart JM. Decreased microvascular nitric oxide-dependent vasodilation in postural tachycardia syndrome. Circulation 112: 2611-2618, 2005.
34. Momen A, Bower D, Leuenberger UA, Boehmer J, Lerner S, Alfrey EJ, Handly B, Sinoway LI. Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control. Am J Physiol Heart Circ Physiol 289: H1770-H1776, 2005.
35. Montgomery LD, Kirk PJ, Payne PA, Gerber RL, Newton SD, Williams BA. Cardiovascular responses of men and women to lower body negative pressure. Aviat Space Environ Med 48: 138-145, 1977.
36. Muenter SN, Charkoudian N, Dotson RM, Suarez GA, Low PA. Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome. Am J Physiol Heart Circ Physiol 289: H1226-H1233, 2005.
37. Nishiyasu T, Tan N, Morimoto K, Sone R, Murakami N. Cardiovascular and humoral responses to sustained muscle metaboreflex activation in humans. J Appl Physiol 84: 116-122, 1998.
38. O'Leary DS. Regional vascular resistance vs. conductance: which index for baroreflex responses? Am J Physiol Heart Circ Physiol 260: H632-H637, 1991.
39. O'Leary DS. Autonomic mechanisms of muscle metaboreflex control of heart rate. J Appl Physiol 74: 1748-1754, 1993.
40. O'Leary DS. Altered reflex cardiovascular control during exercise in heart failure: animal studies. Exp Physiol 91: 73-77, 2006.
41. O'Leary DS, Sala-Mercado JA, Augustyniak RA, Hammond RL, Rossi NF, Ansorge EJ. Impaired muscle metaboreflex-induced increases in ventricular function in heart failure. Am J Physiol Heart Circ Physiol 287: H2612-H2618, 2004.
42. Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 59: 178-193, 1986.
43. Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C, Somers VK. Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 95: 1441-1448, 1997.
44. Pang CC. Autonomic control of the venous system in health and disease: effects of drugs. Pharmacol Ther 90: 179-230, 2001.
45. Sala-Mercado JA, Hammond RL, Kim JK, McDonald PJ, Stephenson LW, O'Leary DS. Heart failure attenuates muscle metaboreflex control of ventricular contractility during dynamic exercise. Am J Physiol Heart Circ Physiol 292: H2159-H2166, 2007.
46. Sala-Mercado JA, Ichinose M, Hammond RL, Ichinose TK, Pallante M, Stephenson LW, O'Leary DS, Iellamo F. Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise. Am J Physiol Heart Circ Physiol 292: H2867-H2873, 2007.
47. Sandroni P, Opfer-Gehrking TL, McPhee BR, Low PA. Postural tachycardia syndrome: clinical features and follow-up study. Mayo Clin Proc 74: 1106-1110, 1999.
48. Schondorf R, Low PA. Idiopathic postural orthostatic tachycardia syndrome: an attenuated form of acute pandysautonomia? Neurology 43: 132-137, 1993.
49. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 342: 541-549, 2000.
50. Sheriff DD, Augustyniak RA, O'Leary DS. Muscle chemoreflex-induced increases in right atrial pressure. Am J Physiol Heart Circ Physiol 275: H767-H775, 1998.
51. Shoemaker JK, Kunselman AR, Silber DH, Sinoway LI. Maintained exercise pressor response in heart failure. J Appl Physiol 85: 1793-1799, 1998.
52. Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol 84: 1551-1559, 1998.
53. Sinoway LI, Li J. A perspective on the muscle reflex: implications for congestive heart failure. J Appl Physiol 99: 5-22, 2005.
54. Smith SA, Mitchell JH, Garry MG. The mammalian exercise pressor reflex in health and disease. Exp Physiol 91: 89-102, 2006.
55. Stewart GN. Researches on the circulation time and on the influences which affect it. IV. The output of the heart. J Physiol 22: 159, 1897.
56. Stewart JM. Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr Res 48: 218-226, 2000.
57. Stewart JM, Glover JL, Medow MS. Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume. Clin Sci (Lond) 110: 255-263, 2006.
58. Stewart JM, McLeod KJ, Sanyal S, Herzberg G, Montgomery LD. Relation of postural vasovagal syncope to splanchnic hypervolemia in adolescents. Circulation 110: 2575-2581, 2004.
59. Stewart JM, Medow MS, Cherniack NS, Natelson BH. Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow. Am J Physiol Heart Circ Physiol 291: H904-H913, 2006.
60. Stewart JM, Medow MS, Glover JL, Montgomery LD. Persistent splanchnic hyperemia during upright tilt in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 290: H665-H673, 2006.
61. Stewart JM, Montgomery LD. Regional blood volume and peripheral blood flow in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 287: H1319-H1327, 2004.
62. Stewart JM, Montgomery LD. Reciprocal splanchnic-thoracic blood volume changes during the Valsalva maneuver. Am J Physiol Heart Circ Physiol 288: H752-H758, 2005.
63. Stewart JM, Montgomery LD, Glover JL, Medow MS. Changes in regional blood volume and blood flow during static handgrip. Am J Physiol Heart Circ Physiol 292: H215-H223, 2007.
64. Stewart JM, Weldon A. Reflex vascular defects in the orthostatic tachycardia syndrome of adolescents. J Appl Physiol 90: 2025-2032, 2001.
65. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 17: 354-381, 1996.
66. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93: 1043-1065, 1996.
67. Taylor JA, Carr DL, Myers CW, Eckberg DL. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation 98: 547-555, 1998.
68. Williams CA. Effect of muscle mass on the pressor response in man during isometric contractions. J Physiol 435: 573-584, 1991.
69. Wray DW, Donato AJ, Nishiyama SK, Richardson RS. Acute sympathetic vasoconstriction at rest and during dynamic exercise in cyclists and sedentary humans. J Appl Physiol 102: 704-712, 2007.
70. Zucker IH. Novel mechanisms of sympathetic regulation in chronic heart failure. Hypertension 48: 1005-1011, 2006.