Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 2, 2006, Pages

  Stewart, Julian M ^a   Medow, Marvin S ^a   Cherniack, Neil S ^b   Natelson, Benjamin H ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Hypocapnia; Orthostatic intolerance; Vasoconstriction

Indexed keywords

ADOLESCENT; ADULT; AIRWAY RESISTANCE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; BLOOD PRESSURE VARIABILITY; BLOOD VOLUME; BREATHING RATE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEART RATE; HEART RATE VARIABILITY; HEMODYNAMICS; HUMAN; HYPEREMIA; HYPERVENTILATION; HYPOCAPNIA; MALE; PLETHYSMOGRAPHY; PNEUMOTACHYGRAPHY; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW; STRAIN GAUGE TRANSDUCER; TACHYCARDIA; VASOCONSTRICTION;

ADOLESCENT; ADULT; BLOOD PRESSURE; CARBON DIOXIDE; ELECTROCARDIOGRAPHY; FEMALE; FOREARM; HEART RATE; HUMANS; HYPERVENTILATION; HYPOCAPNIA; MALE; POSTURE; REGIONAL BLOOD FLOW; SPLANCHNIC CIRCULATION; SUPINE POSITION; SYMPATHETIC NERVOUS SYSTEM; TACHYCARDIA; TIDAL VOLUME; VASOCONSTRICTION;

EID: 33746808099     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01359.2005     Document Type: Article

References (37)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR (text revision). Washington, DC: American Psychiatric Association, 2000.
2. Anthonisen NR, Bartlett D Jr, and Tenney SM. Postural effect on ventilatory control. J Appl Physiol 20: 191-196, 1965.
3. Geddes LA and Baker LE. Detection of physiological events by impedance. In: Principles of Applied Biomedical Instrumentation, New York: Wiley, 1989, p. 594-600.
4. Geddes LA and Kidder H. Specific resistance of blood at body temperature II. Med Biol Eng 14: 180-185, 1976.
5. 2 transient during standing up in humans. J Physiol 554: 579-590, 2004.
6. Greenfield AD, Whitney RJ, and Whitney RJ. Methods for the investigation of peripheral blood flow. Br Med Bull 19: 101-109, 1963.
7. 2 chemoreflexes and arterial baroreflexes. Am J Physiol Heart Circ Physiol 274: H2177-H2187, 1998.
8. Hirshoren N, Tzoran I, Makrienko I, Edoute Y, Plawner MM, Itskovitz-Eldor J, and Jacob G. Menstrual cycle effects on the neurohumoral and autonomic nervous systems regulating the cardiovascular system. J Clin Endocrinol Metab 87: 1569-1575, 2002.
9. Hughson RL, Edwards MR, O'Leary DD, and Shoemaker JK. Critical analysis of cerebrovascular autoregulation during repeated head-up tilt. Stroke 32: 2403-2408, 2001.
10. Kara T, Narkiewicz K, and Somers VK. Chemoreflexes - physiology and clinical implications. Acta Physiol Scand 177: 377-384, 2003.
11. Kay SM and Marple SL. Spectrum analysis - a modern perspective. Proc IEEE 69: 1380-1419. 1981.
12. Kety SS and Schmidt CF. The effects of active and passive hyperventilation on cerebral blood flow, cerebral oxygen consumption, cardiac output, and blood pressure of normal young men. J Clin Invest 25: 107-119, 1946.
13. Krishnamurthy S, Wang X, Bhakta D, Bruce E, Evans J, Justice T, and Patwardhan A. Dynamic cardiorespiratory interaction during head-up tilt-mediated presyncope. Am J Physiol Heart Circ Physiol 287: H2510-H2517, 2004.
14. LeLorier P, Klein GJ, Krahn A, Yee R, Skanes A, and Shoemaker JK. Combined head-up tilt and lower body negative pressure as an experimental model of orthostatic syncope. J Cardiovasc Electrophysiol 14: 920-924, 2003.
15. Levine BD, Giller CA, Lane LD, Buckey JC, and Blomqvist CG. Cerebral versus systemic hemodynamics during graded orthostatic stress in humans. Circulation 90: 298-306, 1994.
16. Low PA, Opfer-Gehrking TL, Textor SC, Benarroch EE, Shen WK, Schondorf R, Suarez GA, and Rummans TA. Postural tachycardia syndrome (POTS). Neurology 45: S19-S25, 1995.
17. Malliani A, Pagani M, Lombardi F, and Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 84: 482-492, 1991.
18. Marshall JM. Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev 74: 543-594, 1994.
19. Martinon-Torres F, Rodriguez-Nunez A, Fernandez-Cebrian S, Eiris-Punal J, Perez-Munuzuri A, and Martinon-Sanchez JM. The relation between hyperventilation and pediatric syncope. J Pediatr 138: 894-897, 2001.
20. Montgomery LD, Hanish HM, and Marker RA. An impedance device for study of multisegment hemodynamic changes during orthostatic stress. Aviat Space Environ Med 60: 1116-1122, 1989.
21. Naschitz JE, Rosner I, Rozenbaum M, Gaitini L, Bistritzki I, Zuckerman E, Sabo E, and Yeshurun D. The capnography head-up tilt test for evaluation of chronic fatigue syndrome. Semin Arthritis Rheum 30: 79-86, 2000.
22. Novak V, Spies JM, Novak P, McPhee BR, Rummans TA, and Low PA. Hypocapnia and cerebral hypoperfusion in orthostatic intolerance. Stroke 29: 1876-1881, 1998.
23. Okazaki K, Fu Q, Martini ER, Shook R, Conner C, Zhang R, Crandall CG, and Levine BD. Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure. Am J Physiol Regul Integr Comp Physiol 289: R1354-R1359, 2005.
24. Onrot J, Goldberg MR, Hollister AS, Biaggioni I, Robertson RM, and Robertson D. Management of chronic orthostatic hypotension. Am J Med 80: 454-464, 1986.
25. Richardson DW, Kontos HA, Raper AJ, and Patterson JL Jr. Systemic circulatory responses to hypocapnia in man. Am J Physiol 223: 1308-1312, 1972.
26. Sandroni P, Opfer-Gehrking TL, McPhee BR, and Low PA. Postural tachycardia syndrome: clinical features and follow-up study. Mayo Clin Proc 74: 1106-1110, 1999.
27. Schondorf R, Benoit J, and Stein R. Cerebral autoregulation is preserved in postural tachycardia syndrome. J Appl Physiol 99: 828-835, 2005.
28. Serrador JM, Bondar RL, and Hughson RL. Ventilatory response to passive head up tilt. Adv Exp Med Biol 450: 133-139, 1998.
29. 2. Am J Physiol Regul Integr Comp Physiol 290: R1087-R1093, 2006.
30. Shepherd JT. The lungs as receptor sites for cardiovascular regulation. Circulation 63: 1-10, 1981.
31. 2) inversely affects MSNA response to orthostatic stress. Am J Physiol Heart Circ Physiol 281: H1040-H1046, 2001.
32. Stewart JM. Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects. Circulation 105: 2274-2281, 2002.
33. Stewart JM, Medow MS, Glover JL, and Montgomery LD. Persistent splanchnic hyperemia during upright tilt in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 290: H665-H673, 2006.
34. Stewart JM, Medow MS, Montgomery LD, Glover JL, and Millonas MM. Splanchnic hyperemia and hypervolemia during Valsalva maneuver in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 289: H1951-H1959, 2005.
35. Tanaka M, Sato M, Umehara S, and Nishikawa T. Influence of menstrual cycle on baroreflex control of heart rate: comparison with male volunteers. Am J Physiol Regul Integr Comp Physiol 285: R1091-R1097, 2003.
36. Tani H, Singer W, McPhee BR, Opfer-Gehrking TL, Haruma K, Kajiyama G, and Low PA. Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS). Auton Neurosci 86: 107-113, 2000.
37. Van De Borne P, Mezzetti S, Montano N, Narkiewicz K, Degaute JP, and Somers VK. Hyperventilation alters arterial baroreflex control of heart rate and muscle sympathetic nerve activity. Am J Physiol Heart Circ Physiol 279: H536-H541, 2000.