Biochemical properties of an intracellular serpin from Echinococcus multilocularis

Molecular and Biochemical Parasitology

Volumn 156, Issue 1, 2007, Pages 84-88

  Merckelbach, Armin ^a   Ruppel, Andreas ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Echinococcus; Intracellular; Multilocularis; RCL; Reactive center loop; Recombinant; Serpin

Indexed keywords

LEUKOCYTE ELASTASE; SERINE PROTEINASE INHIBITOR;

ARTICLE; ECHINOCOCCUS MULTILOCULARIS; ESCHERICHIA COLI; IMMUNE SYSTEM; ION EXCHANGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ISOLATION; PROTEIN PURIFICATION;

ANIMALS; ECHINOCOCCUS MULTILOCULARIS; ESCHERICHIA COLI; HELMINTH PROTEINS; HUMANS; LEUKOCYTE ELASTASE; PANCREATIC ELASTASE; RECOMBINANT PROTEINS; SERPINS; TRYPSIN INHIBITORS;

ECHINOCOCCUS; ECHINOCOCCUS MULTILOCULARIS; ESCHERICHIA COLI; SUIDAE;

EID: 34548443018     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2007.07.013     Document Type: Article

References (19)

1. Law R.H., Zhang Q., McGowan S., et al. An overview of the serpin superfamily. Genome Biol 7 (2006) 216.1-216.11
2. Irving J.A., Pike R.N., Lesk A.M., and Whisstock J.C. Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function. Genome Res 10 (2000) 1845-1864
3. Krem M.M., and Di Cera E. Conserved Ser residues, the shutter region, and speciation in serpin evolution. J Biol Chem 278 (2003) 37810-37814
4. Silverman G.A., Whisstock J.C., Askew D.J., et al. Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis. Cell Mol Life Sci 61 (2004) 301-325
5. Riewald M., and Schleef R.R. Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues. J Biol Chem 271 (1996) 14526-14532
6. Cooley J., Takayama T.K., Shapiro S.D., Schechter N.M., and Remold-O'Donnell E. The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry 40 (2001) 15762-15770
7. Hirst C.E., Buzza M.S., Bird C.H., et al. The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol 170 (2003) 805-815
8. Zhang M., Park S.M., Wang Y., et al. Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Immunity 24 (2006) 451-461
9. Vuitton D.A., Zhang S.L., Yang Y., et al. Survival strategy of Echinococcus multilocularis in the human host. Parasitol Int 55 Suppl (2006) S51-S55
10. Merckelbach A., Wager M., and Lucius R. Analysis of cDNAs coding for immunologically dominant antigens from an oncosphere-specific cDNA library of Echinococcus multilocularis. Parasitol Res 90 (2003) 493-501
11. Cole E.B., Miller D., Rometo D., et al. Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin. Biochemistry 43 (2004) 11750-11759
12. Remold-O'Donnell E., Nixon J.C., and Rose R.M. Elastase inhibitor. Characterization of the human elastase inhibitor molecule associated with monocytes, macrophages, and neutrophils. J Exp Med 169 (1989) 1071-1086
13. Johnson D., and Travis J. The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center. J Biol Chem 254 (1979) 4022-4026
14. Travis J., Owen M., George P., et al. Isolation and properties of recombinant DNA produced variants of human alpha 1-proteinase inhibitor. J Biol Chem 260 (1985) 4384-4389
15. Zhou A., Carrell R.W., and Huntington J.A. The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop. J Biol Chem 276 (2001) 27541-27547
16. Lethbridge R.C. The biology of the oncosphere of Cyclophyllidean Cestodes. Helminthol Abstr 49 (1980) 59-72
17. White Jr. A.C., Molinari J.L., Pillai A.V., and Rege A.A. Detection and preliminary characterization of Taenia solium metacestode proteases. J Parasitol 78 (1992) 281-287
18. Ritchie H., and Booth N.A. Secretion of plasminogen activator inhibitor 2 by human peripheral blood monocytes occurs via an endoplasmic reticulum-golgi-independent pathway. Exp Cell Res 242 (1998) 439-450
19. Prevot P.P., Adam B., Zouaoui Boudjeltia K., et al. Anti-haemostatic effects of a serpin from the saliva of the tick Ixodes ricinus. J Biol Chem 281 (2006) 26361-26369