Gabapentin for the treatment of neuropathic pain in a pregnant horse

Journal of the American Veterinary Medical Association

Volumn 231, Issue 5, 2007, Pages 755-758

  Davis, Jennifer L ^a   Posner, Lysa P ^a   Elce, Yvonne ^a,b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMINE; ANALGESIC AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; GABAPENTIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CASE REPORT; COLIC; FEMALE; HORSE; NEURALGIA; PAIN ASSESSMENT; POSTOPERATIVE COMPLICATION; PREGNANCY; SAFETY; TREATMENT OUTCOME;

AMINES; ANALGESICS; ANIMALS; COLIC; CYCLOHEXANECARBOXYLIC ACIDS; FEMALE; GAMMA-AMINOBUTYRIC ACID; HORSES; NEURALGIA; PAIN MEASUREMENT; POSTOPERATIVE COMPLICATIONS; PREGNANCY; SAFETY; TREATMENT OUTCOME;

EQUIDAE;

EID: 34548436886     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.231.5.755     Document Type: Article

References (21)

1. Rothenbuhler R, Hawkins JF, Adams SB, et al. Evaluation of surgical treatment for signs of acute abdominal pain in draft horses: 72 cases (1983-2002). J Am Vet Med Assoc 2006;228:1546-1550.
2. Kraus BM, Parente EJ, Tulleners EP. Laryngoplasty with ventriculectomy or ventriculocordectomy in 104 draft horses (1992-2000). Vet Surg 2003;32:530-538.
3. Gleed R, Short CE. A retrospective study of the anesthetic management of adult draft horses. Vet Med Small Anim Clin 1980;75:1409-1416.
4. Jensen TS, Gottrup H, Sindrup SH, et al. The clinical picture of neuropathic pain. Eur J Pharmacol 2001;429:1-11.
5. Gustafsson H, Flood K, Berge OG, et al. Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. Exp Neurol 2003;182:427-434.
6. Jensen TS. Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain 2002;6(suppl A):61-68.
7. Sindrup SH, Otto M, Finnerup NB, et al. Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol 2005;96:399-409.
8. Smith LJ, Shih A, Miletic G, et al. Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain. Pain 2002;97:267-273.
9. Govendir M, Perkins M, Malik R. Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. Aust Vet J 2005;83:602-608.
10. Radulovic LL, Turck D, von Hodenberg A, et al. Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys. Drug Metab Dispos 1995;23:441-448.
11. Maneuf YP, Luo ZD, Lee K. alpha2delta and the mechanism of action of gabapentin in the treatment of pain. Semin Cell Dev Biol 2006;17:565-570.
12. B receptors do not mediate the inhibitory actions of gabapentin on the spinal reflex in rats. J Pharmacol Sci 2004;96:444-449.
13. Gee NS, Brown JP, Dissanayake VU, et al. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 1996;271:5768-5776.
14. Field MJ, Hughes J, Singh L. Further evidence for the role of the alpha(2)delta subunit of voltage dependent calcium channels in models of neuropathic pain. Br J Pharmacol 2000;131:282-286.
15. Patel MK, Gonzalez MI, Bramwell S, et al. Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord. Br J Pharmacol 2000;130:1731-1734.
16. Norton JW. Gabapentin withdrawal syndrome. Clin Neuropharmacol 2001;24:245-246.
17. Gabapentin [package insert]. New York: Pfizer/Parke-Davis, 2005.
18. Ohman I, Vitols S, Tomson T. Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy? Epilepsia 2005;46:1621-1624.
19. Montouris G. Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry. Epilepsy Behav 2003;4:310-317.
20. Newton SA, Knottenbelt DC, Eldridge PR. Headshaking in horses: possible aetiopathogenesis suggested by the results of diagnostic tests and several treatment regimes used in 20 cases. Equine Vet J 2000;32:208-216.
21. Collins NM, Keen JA, Barakzai SZ, et al. Suspected complex regional pain syndrome in 2 horses. J Vet Intern Med 2006;20:1014-1017.