Regulation of 17β-hydroxysteroid dehydrogenase type 2, type 4 and type 5 by calcitriol, LXR agonist and 5α-dihydrotestosterone in human prostate cancer cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 107, Issue 1-2, 2007, Pages 100-105

  Wang, Jing Huan ^a,b   Tuohimaa, Pentti ^a,b,c  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

AR; Calcitriol; Gene regulation and prostate cancer; HSD17B2; HSD17B4; HSD17B5; LXR; VDR

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2; 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 4; 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 5; ANDROGEN RECEPTOR; ANDROSTANOLONE; CALCITRIOL; LIGAND; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; MESSENGER RNA; TESTOSTERONE 17BETA DEHYDROGENASE; TO 901317; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR; 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 5, HUMAN; 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5, HUMAN; CELL RECEPTOR; DNA BINDING PROTEIN; ESTRADIOL 17BETA DEHYDROGENASE; FLUORINATED HYDROCARBON; HSD17B2 PROTEIN, HUMAN; HSD17B4 PROTEIN, HUMAN; HYDROLYASE; HYDROXYSTEROID DEHYDROGENASE; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; SULFONAMIDE; TO-901317;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROSTATE CANCER; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; STROMA CELL; UPREGULATION; BIOSYNTHESIS; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYMOLOGY; MALE; PROSTATE; TUMOR CELL LINE;

17-HYDROXYSTEROID DEHYDROGENASES; CALCITRIOL; CELL LINE, TUMOR; DIHYDROTESTOSTERONE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ESTRADIOL DEHYDROGENASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDRO-LYASES; HYDROCARBONS, FLUORINATED; MALE; PROSTATE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; STROMAL CELLS; SULFONAMIDES;

EID: 34548435602     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.02.009     Document Type: Article

References (30)

1. Blomquist C.H., Lindemann N.J., and Hakanson E.Y. 17 Beta-hydroxysteroid and 20 alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity. Arch. Biochem. Biophys. 239 (1985) 206-215
2. Casey M.L., MacDonald P.C., and Andersson S. 17 Beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J. Clin. Invest. 94 (1994) 2135-2141
3. Wu L., Einstein M., Geissler W.M., Chan H.K., Elliston K.O., and Andersson S. Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. J. Biol. Chem. 268 (1993) 12964-12969
4. Moghrabi N., Head J.R., and Andersson S. Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver. J. Clin. Endocrinol. Metab. 82 (1997) 3872-3878
5. Peltoketo H., Vihko P., and Vihko R. Regulation of estrogen action: role of 17 beta-hydroxysteroid dehydrogenases. Vitam. Horm. 55 (1999) 353-398
6. Blomquist C.H., Leung B.S., Zhang R., Zhu Y., and Chang P.M. Properties and regulation of 17 beta-hydroxysteroid oxidoreductase of OVCAR-3, CAOV-3, and A431 cells: effects of epidermal growth factor, estradiol, and progesterone. J. Cell. Biochem. 59 (1995) 409-417
7. Ghersevich S., Akinola L., Kaminski T., Poutanen M., Isomaa V., Vihko R., and Vihko P. Activin-A, but not inhibin, regulates 17beta-hydroxysteroid dehydrogenase type 1 activity and expression in cultured rat granulosa cells. J. Steroid Biochem. Mol. Biol. 73 (2000) 203-210
8. Poutanen M., Isomaa V., Kainulainen K., and Vihko R. Progestin induction of 17 beta-hydroxysteroid dehydrogenase enzyme protein in the T-47D human breast-cancer cell line. Int. J. Cancer 46 (1990) 897-901
9. Hughes S.V., Robinson E., Bland R., Lewis H.M., Stewart P.M., and Hewison M. 1,25-dihydroxyvitamin D3 regulates estrogen metabolism in cultured keratinocytes. Endocrinology 138 (1997) 3711-3718
10. Elo J.P., Harkonen P., Kyllonen A.P., Lukkarinen O., Poutanen M., Vihko R., and Vihko P. Loss of heterozygosity at 16q24.1-q24.2 is significantly associated with metastatic and aggressive behavior of prostate cancer. Cancer Res. 57 (1997) 3356-3359
11. Elo J.P., Harkonen P., Kyllonen A.P., Lukkarinen O., and Vihko P. Three independently deleted regions at chromosome arm 16q in human prostate cancer: allelic loss at 16q24.1-q24.2 is associated with aggressive behaviour of the disease, recurrent growth, poor differentiation of the tumour and poor prognosis for the patient. Br. J. Cancer 79 (1999) 156-160
12. Elo J.P., Akinola L.A., Poutanen M., Vihko P., Kyllonen A.P., Lukkarinen O., and Vihko R. Characterization of 17beta-hydroxysteroid dehydrogenase isoenzyme expression in benign and malignant human prostate. Int. J. Cancer 66 (1996) 37-41
13. Hanchette C.L., and Schwartz G.G. Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer 70 (1992) 2861-2869
14. Tuohimaa P., Tenkanen L., Ahonen M., Lumme S., Jellum E., Hallmans G., Stattin P., Harvei S., Hakulinen T., Luostarinen T., Dillner J., Lehtinen M., and Hakama M. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int. J. Cancer 108 (2004) 104-108
15. Ahonen M.H., Tenkanen L., Teppo L., Hakama M., and Tuohimaa P. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Contr 11 (2000) 847-852
16. Penning T.M. Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action. Hum. Reprod. Update 9 (2003) 193-205
17. Penning T.M., Burczynski M.E., Jez J.M., Lin H.K., Ma H., Moore M., Ratnam K., and Palackal N. Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3). Mol. Cell. Endocrinol. 171 (2001) 137-149
18. Luu-The V., Dufort I., Pelletier G., and Labrie F. Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women. Mol. Cell. Endocrinol. 171 (2001) 77-82
19. Jakob F., Homann D., and Adamski J. Expression and regulation of aromatase and 17 beta-hydroxysteroid dehydrogenase type 4 in human THP 1 leukemia cells. J. Steroid Biochem. Mol. Biol. 55 (1995) 555-563
20. Jenster G. The role of the androgen receptor in the development and progression of prostate cancer. Semin. Oncol. 26 (1999) 407-421
21. Arnold J.T., and Isaacs J.T. Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault. Endocr. Relat. Cancer 9 (2002) 61-73
22. Castagnetta L.A., Carruba G., Traina A., Granata O.M., Markus M., Pavone-Macaluso M., Blomquist C.H., and Adamski J. Expression of different 17beta-hydroxysteroid dehydrogenase types and their activities in human prostate cancer cells. Endocrinology 138 (1997) 4876-4882
23. Luu-The V. Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase. J. Steroid Biochem. Mol. Biol. 76 (2001) 143-151
24. Harkonen P., Torn S., Kurkela R., Porvari K., Pulkka A., Lindfors A., Isomaa V., and Vihko P. Sex hormone metabolism in prostate cancer cells during transition to an androgen-independent state. J. Clin. Endocrinol. Metab. 88 (2003) 705-712
25. Frenoux J.M., Vernet P., Volle D.H., Britan A., Saez F., Kocer A., Henry-Berger J., Mangelsdorf D.J., Lobaccaro J.M., and Drevet J.R. Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions. J. Mol. Endocrinol. 33 (2004) 361-375
26. Lou Y.R., Laaksi I., Syvala H., Blauer M., Tammela T.L., Ylikomi T., and Tuohimaa P. 25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells. Faseb J. 18 (2004) 332-334
27. Zhao X.Y., Ly L.H., Peehl D.M., and Feldman D. 1alpha,25-dihydroxyvitamin D3 actions in LNCaP human prostate cancer cells are androgen-dependent. Endocrinology 138 (1997) 3290-3298
28. Wang T.T., Tavera-Mendoza L.E., Laperriere D., Libby E., MacLeod N.B., Nagai Y., Bourdeau V., Konstorum A., Lallemant B., Zhang R., Mader S., and White J.H. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 19 (2005) 2685-2695
29. Miettinen M.M., Mustonen M.V., Poutanen M.H., Isomaa V.V., and Vihko R.K. Human 17 beta-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell- and tissue-specific expression. Biochem. J. 314 Pt 3 (1996) 839-845
30. Robertson K.M., Schuster G.U., Steffensen K.R., Hovatta O., Meaney S., Hultenby K., Johansson L.C., Svechnikov K., Soder O., and Gustafsson J.A. The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis. Endocrinology 146 (2005) 2519-2530