Cell type-specific expression of 17β-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 11, 1997, Pages 3872-3878

  Moghrabi, Nabil ^a   Head, Judith R ^b   Andersson, Stefan ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE 17BETA DEHYDROGENASE;

ARTICLE; CATALYSIS; CELL SPECIFICITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LOCALIZATION; FETUS LIVER; GRANULOSA CELL; HORMONE METABOLISM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PLACENTA; PRIORITY JOURNAL; PROTEIN ANALYSIS; SYNCYTIOTROPHOBLAST;

EID: 0030670460     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.11.4391     Document Type: Article

References (20)

1. Siiteri PK, MacDonald PC. 1966 Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab. 26:751-761.
2. Ryan KJ. 1957 Metabolism of C-16-oxvgenated steroids by human placenta: the formation of estriol. J Biol Chem. 234:2006-2008.
3. Boité E, Wiqvist N, Diczfalusy E. 1966 Metabolism of dehydroepiandrosterone and dehydroepiandrosterone sulfate by the human foetus at midpregnancy. Acta Endocrinol (Copenh). 52:583-597.
4. Gurpide E, Schweres J, Welch MT, Vande Wiele RL, Lieberman S. 1966 Fetal and maternal metabolism of estradiol during pregnancy. J Clin Endocrinol Metab. 26:1355-1365.
5. MacDonald PC. 1965 Placental steroidogenesis. In: Wynn RM, ed. Fetal homeostasis. New York: New York Academy of Sciences; 265-299.
6. Gurpide E, Marks C, de Ziegler D, Berk PD, Brandes JM. 1982 Assymetric release of estrone and estradiol derived from labeled precursors in perfused human placentas. Am J Obstet Gynecol. 144:551-555.
7. Walsh SW, McCarthy MS. 1981 Selective placental secretion of estrogens into fetal and maternal circulations. Endocrinology. 109:2152-2159.
8. Benirschke K, Kaufmann P. 1995 Pathology of the human placenta, 3rd ed. New York: Springer Verlag.
9. Andersson S, Moghrabi N. 1997 Physiology and molecular genetics of 17β-hydroxysteroid dehydrogenases. Steroids. 62:143-147.
10. Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S. 1993 Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. J Biol Chem. 169:12964-12969.
11. Luu-The V, Labrie C, Simard J, et al. 1990 Structure of two in tandem human 17β-hydroxysteroid dehydrogenase genes. Mol Endocrinol. 4:268-275.
12. Martel C, Rhéaume E, Takahashi M, et al. 1992 Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues. J Steroid Biochem Mol Biol. 41:597-603.
13. Casey ML, MacDonald PC, Andersson S. 1994 17β-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J Clin Invest. 94:2135-2141.
14. Fournet-Dulguerov N, MacLusky NJ, Leranth CZ, et al. 1987 Immunohistochemical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta. J Clin Endocrinol Metab. 65:757-764.
15. Patel S, Einstein M, Geissler W, Wu L, Andersson S. 1996 Immunohistochemical analysis of steroid 5α-reductase type 1 in human scalp and prostate. Ann NY Acad Sci. 784:27-39.
16. Harlow E, Lane D. 1988 Antibodies: a laboratory manual. Cold Spring Harbor: Cold Spring Harbor Laboratory.
17. 3 in rat liver microsomes. J Biol Chem. 261:16932-16936.
18. Head JR, MacDonald PC, Casey ML. 1993 Cellular localization of membrane metalloendopeptidase (enkephalinase) in human endometrium during the ovarian cycle. J Clin Endocrinol Metab. 76:769-776.
19. Beaudoin C, Blomquist CH, Tremblay Y. 1995 Gene expression of 17β-hydroxysteroid dehydrogenase type 2 isozyme in primary cultures of human trophoblasts predicts different mechanisms regulating type 1 and type 2 enzymes. J Clin Endocrinol Metab. 136:3807-3814.
20. Ratanasavanh D, Beaune P, Morel F, Flinois J-P, Guengerich FP, Guillouzo A. 1991 Intralobular distribution and quantitation of cytochrome P450 enzymes in human liver as a function of age. Hepatology. 13:1142-1151.