A linear mixed-effects statistical model for in-vivo evaluation of recombinant human growth hormone implants in hypophysectomized rats

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 9, 2007, Pages 1313-1317

  Santovena A ^a   Garcia J T ^a   Farina J B ^a   Llabres M ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE;

ARTICLE; BIODEGRADABLE IMPLANT; BODY WEIGHT; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; EVALUATION; HORMONE ACTION; HORMONE RELEASE; HYPOPHYSECTOMY; IN VIVO STUDY; MULTIVARIATE ANALYSIS OF VARIANCE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; STATISTICAL MODEL;

ANIMALS; BODY WEIGHT; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; DRUG IMPLANTS; HUMAN GROWTH HORMONE; HYPOPHYSECTOMY; INJECTIONS, SUBCUTANEOUS; LINEAR MODELS; MULTIVARIATE ANALYSIS; RANDOM ALLOCATION; RATS; TIME FACTORS;

EID: 34548432664     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.9.0017     Document Type: Article

References (13)

1. Carrillo, A., Rising, R., Cole, C., Tverskaya, R., Liftshitz, F. (2000) Low dosages of exogenous growth hormone and its effect on growth in an animal model of suboptimal nutrition. Nutrition 16: 1074-1078
2. Clark, R. G., Mortensen, D. L., Carlsson, L. M. S., Spencer, S. A., McKay, P., Mulkerrin, M., Moore, J., Cunningham, B. C. (1996) Recombinant human growth hormone (GH)-binding protein enhances the growth-promoting activity of human GH in the rat. Endocrinology 137: 4308-4315
3. Evans, H. M., Simpson, M. E., Marx, W., Kibrick, E. (1943) Bioassay of the pituitary growth hormone. Width of the proximal epiphysial cartilage of the tibia in hypophysectomized rats. Endocrinology 32: 13-16
4. García, J. T., Dorta, M. J., Munguía, O., Llabrés, M., Fariña, J. B. (2002) Biodegradable laminar implants for sustained release of recombinant human growth hormone. Biomaterials 23: 4759-4764
5. Kim, S. J., Hahn, S. K., Kim, M. J., Kim, D. H., Lee, Y. P. (2005) Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles. J. Control. Release 104: 323-335
6. Pinheiro, J. C., Bates, D. M. (2000) Linear mixed-effects models. In: Mixed-effects models in S and S-PLUS. Springer-Verlag, New York
7. Rising, R., Scaglia, J. F., Cole, C., Tverskaya, R., Duro, D., Lifshitz, F. (2005) Exogenous recombinant human growth hormone effects during suboptimal energy and zinc intake. Nutr. Metab. 2: 10-25
8. Santoveña, A., García, J. T., Oliva, A., Llabrés, M., Fariña, J. B. (2006) A mathematical model for interpreting in vitro rhGH release from laminar implants. Int. J. Pharm. 309: 38-43
9. Software R version 2. 1. 1. (2006) http://cran.r-project.org/ (accessed 25 July 2006)
10. Takada, S., Kurokawa, T., Misaki, M., Taira, K., Yamagata Y. (2003a) A new animal model for evaluation of long-term growth rate over one month by rhGH/PLGA microcapsule formulations. J. Pharm. Pharmacol. 55: 951-961
11. Takada, S., Yamagata, Y., Misaki, M., Taira, K., Kurokawa, T. (2003b) Sustained release of human growth hormone form microcapsules prepared by a solvent evaporation technique. J. Control. Release 88: 229-242
12. Thakkar, A. L., Harrison, R. G., Moore, D. L. (1998) Injectable sustained release formulations, US Patent No. 4997659
13. Van Dyke, H. B., Wallen-Lawrence, Z. (1930) On the growth promoting hormone of the pituitary body. J. Pharmacol. Exp. Ther. 40: 413-422