Inducible NO synthase expression in endomyocardial biopsies after heart transplantation in relation to the postoperative course

European Journal of Cardio-thoracic Surgery

Volumn 32, Issue 4, 2007, Pages 639-643

  Koch, Achim ^a   Burgschweiger, Andreas ^b   Herpel, Esther ^a   Sack, Falk Udo ^a   Schirmacher, Peter ^a   Szabo, Gabor B ^a   Karck, Matthias ^a   Schnabel, Philipp A ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b St Hedwig Klinik GmbH   (Germany)

Author keywords

Heart transplantation; Rejection iNOS expression

Indexed keywords

ADRENALIN; AZATHIOPRINE; CYCLOSPORIN A; DOBUTAMINE; IMMUNOSUPPRESSIVE AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INOTROPIC AGENT; NITRIC OXIDE; NORADRENALIN; PREDNISONE; THYMOCYTE ANTIBODY;

ACUTE GRAFT REJECTION; ADULT; AGED; ARTICLE; CARDIAC GRAFT REJECTION; CLINICAL ARTICLE; ENDOTHELIUM CELL; FEMALE; GRAFT REJECTION; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ORGAN TRANSPLANTATION; POSTOPERATIVE CARE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; VASCULAR SMOOTH MUSCLE;

AGED; BIOPSY; ENDOCARDIUM; FEMALE; GENE EXPRESSION; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; ISCHEMIA; MALE; MIDDLE AGED; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE SYNTHASE TYPE II; PREDICTIVE VALUE OF TESTS;

EID: 34548430482     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2007.06.041     Document Type: Article

References (25)

1. Trulock E.P., Edwards L.B., Taylor D.O., Boucek M.M., Keck B.M., Hertz M.I., Hertz M.I., and International Society for Heart and Lung Transplantation. Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult lung and heart-lung transplantation report. J Heart Lung Transplant 25 8 (2006) 880-892
2. Pethig K., Dengler T.J., Mohacsi P., Deng M.C., and Wahlers T. Long-term management after heart transplantation-an assessment of current status. Z Kardiol 89 (2000) 93-99
3. Moncada S., Palmer R.M., and Higgs E.A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43 (1991) 109-142
4. Forstermann U., Closs E.I., Pollock J.S., Nakan M., Schwarz P., Gath I., and Kleinert H. Nitric oxide synthase isoenzymes: characterisation, purification molecular cloning and functions. Hypertension 23 (1994) 1121-1131
5. Forstermann U., Schmidt H.H.W., Pollock J.S., Sheng H., Mitchell J.A., Warner T.D., Nakane M., and Murad F. Isoforms of nitric oxide synthase: characterisation and purification from different cell types. Biochem Pharmacol 42 (1991) 1848-1857
6. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 6 (1992) 3051-3064
7. Cannon P.J., Xiaochun Y., Szabolcs M.J., Ravalli S., Sciacca R.R., and Michler R.E. The role of inducible nitric oxide synthase in cardiac allograft rejection. Cardiovasc Res 38 (1998) 6-15
8. Fukuchi M., Hussain S.N.A., and Giaid A. Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure. Their relation to lesion site and ß-adrenergic receptor therapy. Circulation 98 (1998) 132-139
9. Winlaw D.S., Schyvens C.G., Smythe G.A., Du Z., Rainer S.P., Keogh A.M., Mundy J.A., Lord R.S., Spratt P.M., and Mc Donald P.S. Urinary nitrate excretion is a non-invasive indicator of acute cardiac allograft rejection and nitric oxide production in the rat. Transplantation 58 (1994) 1031-1036
10. Albrecht E.W.J.A., Van Goor H., Tiebosch A.T.M.G., Moshage H., Tegzess A.M., and Stegeman C.A. Nitric oxide production and nitric oxide synthase expression in acute human renal allograft rejection. Transplantation 70 (2000) 1610-1616
11. Szabolcs M.J., Ravalli S., Minanov O., Sciacca R.R., Michler R.E., and Cannon P.J. Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection. Transplantation 65 (1998) 804-812
12. Kobayashi J., Crawford S.E., Backer C.L., Zales V.R., Takami H., Hsueh C., Huang L., and Mavroudis C. Captopril reduces graft coronary artery disease in a rat heterotopic transplant model. Circulation 88 (1993) 286-290
13. Lee P.C., Wang Z.L., Qian S., Watkins S.C., Lizonova A., Kovesdi I., Tzeng E., Simmons R.L., Billiar T.R., and Shears L.L. Endothelial nitric oxide synthase protects aortic allografts from the development of transplant arteriosclerosis. Transplantation 69 (2000) 1186-1192
14. Broekman M.J., Eiroa A.M., and Marcus A.J. Inhibition of human platelet reactivity by endothelium-derived relaxing factor from human umbilical vein endothelial cells in suspension, blockade of aggregation and secretion by an aspirin-insensitive mechanism. Blood 78 (1991) 1033-1040
15. Ross R. The pathogenesis of atherosclerosis: a perspective for the 90s. Nature 362 (1993) 801-809
16. Mankad P., and Yacoub M. Influence of basal release of nitric oxide on systolic and diastolic function of both ventricles. J Thorac Cardiovasc Surg 113 (1997) 770-776
17. Finkel M.S., Oddis C.V., Jacob T.D., Watkins S.C., Hattler B.G., and Simmons R.C. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257 (1992) 387-389
18. Thoenes M., Förstermann U., Tracey W.R., Bleese N.M., Nüssler A.K., Scholz H., and Stein B. Expression of inducible nitric oxide synthase in failing and non-failing human heart. J Mol Cell Cardiol 28 (1996) 165-169
19. Sessa W.C. The nitric oxide synthase family of proteins. J Vasc Res 31 (1994) 131-143
20. Li Q.Y., Raza-Ahmad A., MacAulay M.A., Lalonde L.D., Rowden G., Trethewey E., and Dean S. The relationship of mast cells and their secreted products to the volume of fibrosis in post transplant hearts. Transplantation 53 (1992) 1047-1051
21. Pinsky D.J., Cai B., Yang X., Rodriguez C., Sciacca R.R., and Cannon P.J. Lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor ß. J Clin Invest 95 (1995) 677-685
22. Mannon R.B., Roberts K., Ruiz P., Laubach V., and Coffman T.M. Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection. J Heart Lung Transplant 18 (1999) 819-827
23. Worrall N.K., Chang K., Suau G.M., Allison W.S., Misko T.P., Sullivan P.M., Tilton R.G., Williamson J.R., and Ferguson T.B. Inhibition of inducible nitric oxide synthase prevents myocardial and systemic vascular barrier dysfunction during early cardiac allograft rejection. Circ Res 78 (1996) 769-779
24. Worral N.K., Lazenby W.D., Misko T.P., Lin T.S., Rodi C.P., Manning P.T., Tilton R.G., Williamson J.R., and Ferguson T.B. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J Exp Med 181 (1995) 63-70
25. Stoica S.C., Satchithananda D.K., Atkinson C., Charman S., Goddard M., and Large S.R. Heat shock protein, inducible nitric oxide synthase and apoptotic markers in the acute phase of human cardiac transplantation. Eur J Cardiothorac Surg 24 (2003) 932-939