Detection of the nt230(del4) MDR1 mutation in White Swiss Shepherd dogs: Case reports of doramectin toxicosis, breed predisposition, and microsatellite analysis

Journal of Veterinary Pharmacology and Therapeutics

Volumn 30, Issue 5, 2007, Pages 482-485

  Geyer, J ^a   Klintzsch, S ^a   Meerkamp, K ^a   Wohlke A ^b   Distl, O ^b   Moritz, A ^a   Petzinger, E ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DORAMECTIN; MICROSATELLITE DNA; MULTIDRUG RESISTANCE PROTEIN 1;

ALOPECIA; ARTICLE; BREEDING; DOG; FEMALE; FOLLOW UP; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; HAPLOTYPE; MALE; MICROSATELLITE MARKER; NEUROLOGIC EXAMINATION; NEUROTOXICITY; NONHUMAN; NUTRITIONAL SUPPORT; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SKIN DISEASE;

ANIMALS; ANTINEMATODAL AGENTS; BREEDING; DIAGNOSIS, DIFFERENTIAL; DOGS; FEMALE; FRAMESHIFT MUTATION; GENES, MDR; IVERMECTIN; MALE; PEDIGREE;

CANIS FAMILIARIS;

EID: 34548418502     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2007.00885.x     Document Type: Article

References (28)

1. Borst, P. Oude-Elferink, R. (2002) Mammalian ABC transporters in health and disease. Annual Review of Biochemistry, 71, 537 592.
2. Cordon-Cardo, C., O'Brien, J.P., Casals, D., Rittman-Grauer, L., Biedler, J.L., Melamed, M.R. Bertino, J.R. (1989) Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proceedings of the National Academy of Sciences of the United States of America, 86, 695 698.
3. Cordon-Cardo, C., O'Brien, J.P., Boccia, J., Casals, D., Bertino, J.R. Melamed, M.R. (1990) Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. Journal of Histochemistry and Cytochemistry, 38, 1277 1287.
4. Dean, M., Rzhetsky, A. Allikmets, R. (2001) The human ATP-binding cassette (ABC) transporter superfamily. Genome Research, 11, 1156 1166.
5. Fromm, M.F. (2000) P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. International Journal of Clinical Pharmacology and Therapeutics, 38, 69 74.
6. Fromm, M.F. (2004) Importance of P-glycoprotein at blood-tissue barriers. Trends in Pharmacological Sciences, 25, 423 429.
7. Geyer, J., Döring, B., Godoy, J.R., Leidolf, R., Moritz, A. Petzinger, E. (2005a) Frequency of the nt230(del4) MDR1 mutation in Collies and related dog breeds in Germany. Journal of Veterinary Pharmacology and Therapeutics, 28, 545 551.
8. Geyer, J., Döring, B., Godoy, J.R., Moritz, A. Petzinger, E. (2005b) Development of a PCR-based diagnostic test detecting a nt230(del4) MDR1 mutation in dogs: verification in a moxidectin-sensitive Australian Shepherd. Journal of Veterinary Pharmacology and Therapeutics, 28, 95 99.
9. Ginn, P.E. (1996) Immunohistochemical detection of P-glycoprotein in formalin-fixed and paraffin-embedded normal and neoplastic canine tissues. Veterinary Pathology, 33, 533 541.
10. Henik, R.A., Kellum, H.B., Bentjen, S.A. Mealey, K.L. (2006) Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation. Journal of Veterinary Internal Medicine, 20, 415 417.
11. Hopper, K., Aldrich, J. Haskins, S.C. (2002) Ivermectin toxicity in 17 collies. Journal of Veterinary Internal Medicine, 16, 89 94.
12. Lüpke, L. Distl, O. (2005) Microsatellite marker analysis of the genetic variability in Hanoverian Hounds. Journal of Animal Breeding and Genetics, 122, 131 139.
13. Marzolini, C., Paus, E., Buclin, T. Kim, R.B. (2004) Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clinical Pharmacology and Therapeutics, 75, 13 33.
14. Mealey, K.L., Bentjen, S.A., Gay, J.M. Cantor, G.H. (2001) Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics, 11, 727 733.
15. Mealey, K.L., Northrup, N.C. Bentjen, S.A. (2003) Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. Journal of American Veterinary Medical Association, 223, 1453 1455.
16. Mealey, K.L., Gay, J.M., Martin, L.G. Waiting, D.K. (2007) Comparison of the hypothalamic-pituitary-adrenal axis in MDR1-1Δ and MDR1 wildtype dogs. Journal of Veterinary Emergency and Critical Care, 17, 61 66.
17. Neff, M.W., Robertson, K.R., Wong, A.K., Safra, N., Broman, K.W., Slatkin, M., Mealey, K.L. Pedersen, N.C. (2004) Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. Proceedings of the National Academy of Sciences of the United States of America, 101, 11725 11730.
18. Paul, A.J., Tranquilli, W.J., Seward, R.L., Todd, K.S. Jr. Di Pietro, J.A. (1987) Clinical observations in collies given ivermectin orally. American Journal of Veterinary Research, 48, 684 685.
19. Pulliam, J.D. Preston, J.M. (1989) Safety of ivermectin in target animals. In Ivermectin and Abamectin. Ed. Campbell, W.C., pp. 149 161. Springer-Verlag, New York, Berlin, Heidelberg.
20. Pulliam, J.D., Seward, R.L., Henry, R.T. Steinberg, S.A. (1985) Investigating ivermectin toxicity in Collies. Veterinary Medicine, 80, 33 40.
21. Roulet, A., Puel, O., Gesta, S., Lepage, J.F., Drag, M., Soll, M., Alvinerie, M. Pineau, T. (2003) MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. European Journal of Pharmacology, 460, 85 91.
22. Sarkadi, B., Homolya, L., Szakacs, G. Varadi, A. (2006) Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiological Reviews, 86, 1179 1236.
23. Sartor, L.L., Bentjen, S.A., Trepanier, L. Mealey, K.L. (2004) Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity. Journal of Veterinary Internal Medicine, 18, 117 118.
24. Schinkel, A.H. (1997) The physiological function of drug-transporting P-glycoproteins. Seminars in Cancer Biology, 8, 161 170.
25. Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M.M., Pastan, I. Willingham, M.C. (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proceedings of the National Academy of Sciences of the United States of America, 84, 7735 7738.
26. Tranquilli, W.J., Paul, A.J. Seward, R.L. (1989) Ivermectin plasma concentrations in collies sensitive to ivermectin-induced toxicosis. American Journal of Veterinary Research, 50, 769 770.
27. Vaughn, D.M., Simpson, S.T., Blagburn, B.L., Whitmer, W.L., Heddens-Mysinger, R. Hendrix, C.M. (1989) Determination of homovanillic acid, 5-hydroxyindoleacetic acid and pressure in the cerebrospinal fluid of collie dogs following administration of ivermectin. Veterinary Research Communications, 13, 47 55.
28. Yas-Natan, E., Shamir, M., Kleinbart, S. Aroch, I. (2003) Doramectin toxicity in a collie. The Veterinary Record, 153, 718 720.