Possible role of transforming growth factor beta and interleukin-4 in the up-regulation of CLC-2 and CLC-3 in chronic rhinosinusitis

American Journal of Rhinology

Volumn 21, Issue 4, 2007, Pages 389-394

  Li, Huabin ^a,b   Jiang, Hongyan ^a   Cheng, Lei ^b   Oh, Yun ^c   Xu, Geng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Chloride channel; Chronic rhinosinusitis; Cytokine; Interleukin 4; Interleukin 5; Regulation; Transforming growth factor beta

Indexed keywords

CHLORIDE CHANNEL PROTEIN 2; CHLORIDE CHANNEL PROTEIN 3; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; MEMBRANE PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM; ETHMOID SINUS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NOSE POLYP; PATHOGENESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHINOSINUSITIS; SUBMUCOSA; UPREGULATION;

ADULT; CHLORIDE CHANNELS; CHRONIC DISEASE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-4; MALE; MIDDLE AGED; NASAL MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHINITIS; SINUSITIS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 34548392766     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/ajr.2007.21.3045     Document Type: Article

References (23)

1. Kennedy DW. Pathogenesis of chronic rhinosinusitis. Ann Otol Rhinol Laryngol 1313:s6-s9, 2004.
2. Ren CL. Cystic fibrosis gene mutations and chronic rhinosinusitis. J Allergy Clin Immunol 116:463, 2005.
3. Wang X, Kim J, McWilliams R, et al. Increased prevalence of chronic rhinosinusitis in carriers of a cystic fibrosis mutation. Arch Otolaryngol Head Neck Surg 131:237-240, 2005.
4. Bernstein JM, Gorfien J, Noble B, et al. Nasal polyposis: Immunohistochemistry and bioelectrical findings: A hypothesis for the development of nasal polyps. J Allergy Clin Immunol 99:165-175, 1997.
5. Raman V, Clary R, Siegrist KL, et al. Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis. Pediatrics 109:E13, 2002.
6. Yin J, Kuang Z, Mahankali U, et al. Ion transit pathways and gating in ClC chloride channels. Proteins 57:414-421, 2004.
7. Sardini A, Amey JS, Weylandt KH, et al. Cell volume regulation and swelling-activated chloride channels. Biochim Biophys Acta 1618:153-162, 2003.
8. Jentsch TJ, Neagoe I, and Scheel O. CLC chloride channels and transporters. Curr Opin Neurobiol 15:319-325, 2005.
9. Jentsch TJ, Poet M, Fuhrmann JC, et al. Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models. Annu Rev Physiol 67:779-807, 2005.
10. Lipecka J, Bali M, Thomas A, et al. Distribution of ClC-2 chloride channel in rat and human epithelial tissues. Am J Physiol Cell Physiol 282:C805-C816, 2002.
11. Oshima T, Ikeda K, Furukawa M, et al. Expression of the voltage-dependent chloride channel ClC-3 in human nasal tissue. ORL J Otorhinolaryngol Relat Spec 63:82-86, 2001.
12. Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: Establishing definitions for clinic research and patient care. J Allergy Clin Immunol 114:155-212, 2004.
13. Bradley DT, and Kountakis SE. Role of Interleukins and transforming Growth Factor-β in chronic rhinosinusitis and nasal polyposis. Laryngoscope 115:684-686, 2005.
14. Chu S, Blaisdell CJ, Bamford P, et al. Interferon-gamma regulates ClC-2 chloride channel in lung epithelial cells. Biochem Biophys Res Commun 324:31-39, 2004.
15. Besancon F, Przewlocki G, Baro I, et al. Interferon-gamma downregulates CFTR gene expression in epithelial cells. Am J Physiol 267:C1398-C1404, 1994.
16. Bachert C, Gevaert P, Holtappels G, et al. Nasal polyposis: From cytokines to growth. Am J Rhinol 14:279-290, 2000.
17. Van Zele T, Claeys S, Gevaert P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 61:1280-1289, 2006.
18. Anand VK, Kacker A, Orjuela AF, et al. Inflammatory pathway gene expression in chronic rhinosinusitis. Am J Rhinol 20:471-476, 2006.
19. Zhang N, Holtappels G, Claeys C, et al. Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China. Am J Rhinol 20:445-450, 2006.
20. Hao J, Pang YT, and Wang DY. Diffuse mucosal inflammation in nasal polyps and adjacent middle turbinate. Otolaryngol Head Neck Surg 134:267-725, 2006.
21. Galietta LJ, Pagesy P, Folli C, et al. IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro. J Immunol 168:839-845, 2002.
22. Dabbagh K, Takeyama K, Lee HM, et al. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 162:6233-6237, 1999.
23. Han D, Zhou B, Cheng L, et al. P38 MAP-Kinase pathway is involved in the production of CLC-3 in nasal epithelial cells with allergic rhinitis induced by interleukin-4. Laryngoscope 116:1973-1977, 2006.