Repolarization gradients and arrhythmogenicity in the murine heart

Journal of Physiology

Volumn 583, Issue 2, 2007, Pages 419-420

  Killeen, Matthew J ^a   Sabir, Ian N ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION;

ACTION POTENTIAL; ARRHYTHMOGENESIS; ARTICLE; DISEASE PREDISPOSITION; DNA MODIFICATION; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART REPOLARIZATION; HYPOKALEMIA; ISOLATED HEART; LONG QT SYNDROME; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; POTASSIUM CURRENT; PRIORITY JOURNAL; REFRACTORY PERIOD; TRANSGENIC MOUSE; ACTION POTENTIAL DURATION; DEPOLARIZATION; DISPERSION; EARLY AFTERDEPOLARIZATION; HEART MUSCLE REFRACTORY PERIOD; NOTE; PATCH CLAMP TECHNIQUE; REENTRY ARRHYTHMIA;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIAC PACING, ARTIFICIAL; GENOTYPE; HEART; HEART CONDUCTION SYSTEM; KINETICS; LONG QT SYNDROME; MICE; MICE, TRANSGENIC; MUTATION; PHENOTYPE; POTASSIUM CHANNELS; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL;

EID: 34548324772     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.140269     Document Type: Article

References (6)

1. Killeen MJ, Thomas G, Gurung IS, Goddard CA, Fraser JA, Mahaut-Smith MP, Colledge WH, Grace AA & Huang CL (2007). Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf) 189, 33-46.
2. London B (2001). Cardiac arrhythmias: From (transgenic) mice to men. J Cardiovasc Electrophysiol 12, 1089-1091.
3. London B, Baker LC, Petkova-Kirova P, Nerbonne JM, Choi BR & Salama G (2007). Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT. J Physiol 578, 115-129.
4. Papadatos GA, Wallerstein PM, Head CE, Ratcliff R, Brady PA, Benndorf K, Saumarez RC, Trezise AE, Huang CL, Vandenberg JI, Colledge WH & Grace AA (2002). Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A 99, 6210-6215.
5. Sabir IN, Fraser JA, Killeen MJ, Grace AA & Huang CL (2007). The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. Pflugers Arch 454, 209-222.
6. Shimizu W & Antzelevitch C (1999). Cellular basis for long QT, transmural dispersion of repolarization, and torsade de pointes in the long QT syndrome. J Electrocardiol 32(Suppl.), 177-184.