Lipopolysaccharide induces apoptosis of cytotrophoblasts by activating an innate immune reaction in vitro

Chinese Medical Journal

Volumn 120, Issue 15, 2007, Pages 1353-1359

  Li, Si Yang ^a   Shang, Tao ^b   Li, Shu Juan ^b   Rui, Guang Hai ^b   Li, Qiu Ling ^b  

^a No 202 Hospital of PLA   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cytotrophoblast; Innate immunity; Lipopolysaccharide; Tumor necrosis factor a

Indexed keywords

CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; LIPOPOLYSACCHARIDE; PROPIDIUM IODIDE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; CYTOTROPHOBLAST; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; INNATE IMMUNITY; PLACENTA; PROTEIN EXPRESSION; STAINING; STATISTICAL SIGNIFICANCE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EID: 34548320817     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200708010-00011     Document Type: Article

References (37)

1. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-1462.
2. Smith SC, Baker PN, Symonds EM. Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol 1997; 177: 1396-1401.
3. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol 2000; 96: 271-276.
4. Erel CT, Dane B, Calay Z, Kaleli S, Aydinli K. Apoptosis in the placenta of pregnancies complicated with IUGR. Int J Gynaecol Obstet 2001; 73: 229-235.
5. Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez J, Samoto T, Maruo T. Increased apoptosis in the syncytiotrophoblasts in human term placentas complicated with by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 2002; 186: 158-166.
6. Baczyk D, Dunk C, Huppenz B, Maxwell C, Giannoulias D, Roister F, et al. Bi-potential behaviour of cytotrophoblasts in first trimester chorionic villi. Placenta 2006; 27: 367-374.
7. Huppertz B, Kingdom JC. Apoptosis in the trophoblast-role of apoptosis in placental morphogenesis. J Soc Gynecol Investig 2004; 11: 353-362.
8. Soares SC, Fratelli N, Prefurno F, Thilaganathan B. First-trimester uterine artery Doppler and spontaneous preterm delivery. Ultrasound Obstet Gynecol 2007; 29: 146-149.
9. Ball E, Bulmer JN, Ayis S, Lyall F. Robson SC. Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion. J Pathol 2006; 208: 535-542.
10. Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, et al. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2003; 189: 1063-1069.
11. Norwitz ER. Defective implantation and placentation: laying the blueprint for pregnancy complications. Reprod Biomed Online 2006; 13: 591-599.
12. Romero R, Espinoza J, Goncalves LF, Lee W, Treadwell M, Chintala K, et al. The role of inflammation and infection in preterin birth. Semin Reprod Med 2007; 25: 21-39.
13. Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril 2004; 82: 799-804.
14. Hsu CD, Witter FR. Urogenital infection in pre-eclampsia. Int J Gynaecol Obstet 1995; 47: 271-295.
15. Canakci V, Canakci CF, Canakci H, Canakci E, Cicek Y, Ingec M, et al. Periodontal disease as a risk factor for pre-eclampsia: a case control study. J Obstet Gyneacol 2004; 44: 568-573.
16. Herrera JA, Chauduri G, Lopez-Jaramillo P. Is infection a major risk for pre-eclampsia? Medical Hypotheses 2001; 57: 393-397.
17. Wang X, Athayde N, Trudinger B. Placental vascular diseaset and toll-like receptor 4 gene expression. Am J Obstet Gynecol 2005; 192: 961-966.
18. Kim YM, Romero R, Oh SY, Kim CJ, Kilburn BA, Armant DR, et al. Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia? Am J Obstet Gynecol 2005; 193: 921-927.
19. Knofler M, Mosl B, Bauer S, Criesmiger G, Husslein P. TNF-α/TNFRI in primary and immortalized first trimester cytotrophoblpsts. Placenta 2000; 21: 525-535.
20. Frank HG Cell culture models of human trophoblast: primary culture of trophoblast-a workship reporf. Placenta 2000; 21: S120-S122.
21. He LF, Guan KP, Yan Z, Ye HY, Xu KX, Ren L, et al. Enhanced sensitivity to mitomycin C by abating heat shock, protein 70 expression in human cancer cell line of BIU-87. Chin Med J 2005; 118: 1965-1972.
22. Nagamatsu T, Fujii T, Ishikzwa T, Kanai T, Hyodo H, Yamashita T, et al. A primary cell culture system for human cytotrophoblasts of proximal cytotrophoblast cell columns enabling in vitro acquisition of the extra-villous phenotype. Placenta 2004; 25: 153-165.
23. Morrish DW, Dakour J, Li H. Functional regulation of human trophoblast differentation. J Reprod Immunot. 1998; 39: 179-195.
24. Kadyrov M, Kingdom JC, Huppertz B. Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction. Am J Obstet Gynecol 2006; 194: 557-563.
25. Genbacev O, DiFederico E, McMaster M, Fisher SJ. Invasive cytotrophoblast apoptosis in pre-eclampsia. Hum Reprod 1999; 14 Suppl 2: 59-66.
26. Matthiesen L, Berg G, Emerudh J, Ekerfelt C, Jonsson Y, Sharma S. Immunology of preeclampsia. Chem Immunol Allergy 2005; 89: 49-61.
27. Huppertz B, Kingdom JC. Apoptosis in the trophoblast-role of apoptosis in placental morphogenesis. J Soc Gynecol Investig 2004; 11: 353-362.
28. Levy R, Smith SD, Chandler K, Sadovsky Y, Nelson DM. Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor. Am J Physiol Cell Physiol 2000; 278: C982-C988.
29. Koklanaris N, Nwachukwu JC, Huang SJ, Guller S, Karpisheva Y,, Garabedian M, et al. First-trimester trophoblast cell model gene response to hypoxia. Am J Obstet Gynecol 2006; 194: 687-693.
30. Burdon, Mann C, Cindrova-Davies T, Ferguson-Smith AC, Burton GJ. Oxidative Stress and the Induction of eyclooxygenase enzymes and apoptosis in the marine placenta. Placenta 2007; 11: 724-733.
31. Goldman-Wohl D, Vagel S, Regulation of trophoblast invasion from normal implantation to pre-eclampsia, Mol Cell Endocrinol 2002; 187: 233-238.
32. Gunta S. Molecular stepas of tumor necrosis factor receptor-mediated apoptosis. Curr Mol Med 2001; 102: 344-350.
33. Yui J, Hemmings D Garcia-Lloret M, Guilbert LJ. Expression of human p55 and p75 tumor necrosis factor receptors in primary villous trophoblasts and their role in cytotoxic signal transduction. Bio Reprod 1996; 55: 400-409.
34. Hills FA, Abrahams VM, Gonzalez-Timon B, J Francis J, Cloke B, Hinkson L, et al. Heparin prevents programmed cell death in human trophoblast. Mol Hum Reprod 2006; 12: 237-243.
35. Reister F, Frank HG, Kindom JC, Mor G, Regan L, Sullivanm M, et al. Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women. Lab Invest 2000; 81: 1143-1152.
36. Yui J, Garcia-Lloret M, Wegmann P. Cytotoxicy of tumor necrosis factor-α and gamma-interferon against primary human placental trophoblasts. Placenta 1994; 15: 819-835.
37. Kilani RT, Mackova M, Davidge ST, Winkler-Lowen B, Winkler-Lowen B, Demianczuk N, et al. Endogenous tumor necrosis factor α mediates enhanced apoptosis of cultured villous trophoblasts from intrauterine growth-restricted placenta. Reproduction 2007; 133: 257-264.