The neuro-steroid, 3β androstene 17α diol exhibits potent cytotoxic effects on human malignant glioma and lymphoma cells through different programmed cell death pathways

British Journal of Cancer

Volumn 97, Issue 5, 2007, Pages 619-627

  Graf, M R ^a   Jia, W ^a   Loria, R M ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Androstene neuro steroids; Glioblastoma; Lymphoma; Malignant glioma; Programmed cell death

Indexed keywords

3BETA ANDROSTENE 17ALPHA DIOL; 3BETA ANDROSTENE 17BETA DIOL; 3BETA ANDROSTENE 7ALPHA, 17BETA TRIOL; 3BETA ANDROSTENE 7BETA, 17BETA TRIOL; ACRIDINE ORANGE; BAFILOMYCIN A1; NEUROSTEROID; UNCLASSIFIED DRUG; ANDROSTANEDIOL; CASPASE 3; DNA FRAGMENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL ADHESION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DOSE TITRATION; DRUG MECHANISM; GLIOBLASTOMA; HUMAN; HUMAN CELL; LYMPHOMA; PRIORITY JOURNAL; TUMOR GROWTH; CELL STRAIN U937; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; FLOW CYTOMETRY; GLIOMA; METABOLISM; NICK END LABELING; PATHOLOGY; PHAGOSOME; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANDROSTANE-3,17-DIOL; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLIOMA; HUMANS; IN SITU NICK-END LABELING; LYMPHOMA; MOLECULAR STRUCTURE; PHAGOSOMES; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; U937 CELLS;

EID: 34548306820     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603894     Document Type: Article

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