Evidence for two schizophrenia susceptibility genes on chromosome 22q13

Psychiatric Genetics

Volumn 17, Issue 5, 2007, Pages 292-298

  Condra, Jodi A ^a   Neibergs, Holly ^b,c   Wei, Wei ^a,d   Brennan, Mark D ^a,b  

^a University of Louisville School of Medicine   (United States)

^b SureGene LLC   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Disorder; DSM IIIR genetic linkage; Schizoaffective schizophrenia spectrum; Schizotypal personality disorder; Sult4A1; Transmission disequilibrium

Indexed keywords

ARTICLE; CHROMOSOME 22Q; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DOMINANT INHERITANCE; FAMILY STUDY; GENE LINKAGE DISEQUILIBRIUM; GENETIC HETEROGENEITY; GENETIC SUSCEPTIBILITY; HUMAN; MARKER GENE; MICROSATELLITE MARKER; NONPARAMETRIC TEST; PARAMETRIC TEST; POLYMORPHIC LOCUS; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN CONTINENTAL ANCESTRY GROUP; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 22; DENMARK; EUROPEAN CONTINENTAL ANCESTRY GROUP; FAMILY; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SIBLINGS;

EID: 34548303945     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/YPG.0b013e3281ac2345     Document Type: Article

References (40)

1. Abreu PC, Hodge SE, Greenberg DA (2002). Quantification of type I error probabilities for heterogeneity LOD scores. Genet Epidemiol 22:156-169.
2. Altshuler D, Brooks LD, Chakravarti A, Collins FS, Daly MJ, Donnelly P (2005). A haplotype map of the human genome. Nature 437:1299-1320.
3. Badner JA, Gershon ES (2002). Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405-411.
4. Baker K, Baldeweg T, Sivagnanasundaram S, Scambler P, Skuse D (2005). COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol Psychiatry 58:23-31.
5. Brennan MD, Condra J (2005). Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 139:69-72.
6. Brennan MD, Neibergs HL, Phillips K, Moseley S (2000). Polymorphic markers for the arylsulfatase A gene reveal a greatly expanded meiotic map for the human 22q telomeric region. Genomics 63:430-432.
7. Chen WY, Shi YY, Zheng YL, Zhao XZ, Zhang GJ, Chen SQ, et al. (2004). Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. Hum Mol Genet 13:2991-2995.
8. Clayton D (1999). A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65:1170-1177.
9. Cloninger CR, Kaufmann CA, Faraone SV, Malaspina D, Svrakic DM, Harkavy-Friedman J, et al. (1998). Genome-wide search for schizophrenia susceptibility loci: the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet 81:275-281.
10. Craddock N, O'Donovan MC, Owen MJ (2006). Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 32:9-16.
11. DeLisi LE, Shaw SH, Crow TJ, Shields G, Smith AB, Larach VW, et al. (2002). A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry 159:803-812.
12. Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, et al. (2005). Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am J Hum Genet 77:918-936.
13. Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, et al. (2005). Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Biol Psychiatry 57:139-144.
14. Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, et al. (1998). Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet 81:290-295.
15. Gill M, Vallada H, Collier D, Sham P, Holmans P, Murray R, et al. (1996). A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22). Am J Med Genet 67:40-45.
16. Gothelf D, Eliez S, Thompson T, Hinard C, Penniman L, Feinstein C, et al. (2005). COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nat Neurosci 8:1500-1502.
17. Greenberg DA, Abreu PC (2001). Determining trait locus position from multipoint analysis: accuracy and power of three different statistics. Genet Epidemiol 21:299-314.
18. Jorgensen TH, Borglum AD, Mors O, Wang AG, Pinaud M, Flint TJ, et al. (2002). Search for common haplotypes on chromosome 22q in patients with schizophrenia or bipolar disorder from the Faroe Islands. Am J Med Genet 114:245-252.
19. Karayiorgou M, Gogos JA (2004). The molecular genetics of the 22q11-associated schizophrenia. Brain Res Mol Brain Res 132:95-104.
20. Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD, et al. (1998). NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am J Med Genet 81:282-289.
21. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996). Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
22. Laird NM, Lange C (2006). Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet 7:385-394.
23. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, et al. (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 73:34-48.
24. Liu H, Abecasis GR, Heath SC, Knowles A, Demars S, Chen YJ, et al. (2002a). Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc Natl Acad Sci USA 99:16859-16864.
25. Liu H, Heath SC, Sobin C, Roos JL, Galke BL, Blundell ML, et al. (2002b). Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci USA 99:3717-3722.
26. Martin ER, Bass MP, Hauser ER, Kaplan NL (2003). Accounting for linkage in family-based tests of association with missing parental genotypes. Am J Hum Genet 73:1016-1026.
27. Maziade M, Roy MA, Chagnon YC, Cliche D, Fournier JP, Montgrain N, et al. (2005). Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families. Mol Psychiatry 10:486-499.
28. Mowry BJ, Holmans PA, Pulver AE, Gejman PV, Riley B, Williams NM, et al. (2004). Multicenter linkage study of schizophrenia loci on chromosome 22q. Mol Psychiatry 9:784-795.
29. Mukai J, Liu H, Burt RA, Swor DE, Lai WS, Karayiorgou M, et al. (2004). Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nat Genet 36:725-731.
30. Myles-Worsley M, Coon H, McDowell J, Brenner C, Hoff M, Lind B, et al. (1999). Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. Am J Med Genet 88:544-550.
31. Sanders AR, Rusu I, Duan J, Vander Molen JE, Hou C, Schwab SG, et al. (2005). Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia. Mol Psychiatry 10:353-365.
32. Severinsen JE, Als TD, Binderup H, Kruse TA, Wang AG, Vang M, et al. (2006). Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 141:524-533.
33. Takahashi S, Cui YH, Kojima T, Han YH, Zhou RL, Kamioka M, et al. (2003). Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families. Am J Med Genet B Neuropsychiatr Genet 120:11-17.
34. Takahashi S, Faraone SV, Lasky-Su J, Tsuang MT (2005). Genome-wide scan of homogeneous subtypes of NIMH genetics initiative schizophrenia families. Psychiatry Res 133:111-122.
35. Vallada H, Curtis D, Sham PC, Murray RM, McGuffin P, Nanko S, et al. (1995). Chromosome 22 markers demonstrate transmission disequilibrium with schizophrenia. Psychiatr Genet 5:127-130.
36. Verma R, Mukerji M, Grover D, Rao C, Das SK, Kubendran S, et al. (2005). MLC1 gene is associated with schizophrenia and bipolar disorder in Southern India. Biol Psychiatry 58:16-22.
37. Vocero-Akbani A, Helms C, Wang JC, Sanjurjo FJ, Korte-Sarfaty J, Veile RA, et al. (1996). Mapping human telomere regions with YAC and P1 clones: chromosome-specific markers for 27 telomeres including 149 STSs and 24 polymorphisms for 14 proterminal regions. Genomics 36:492-506.
38. Williams HJ, Glaser B, Williams NM, Norton N, Zammit S, MacGregor S, et al. (2005). No association between schizophrenia and polymorphisms in COMT in two large samples. Am J Psychiatry 162:1736-1738.
39. Williams NM, Owen MJ (2004). Genetic abnormalities of chromosome 22 and the development of psychosis. Curr Psychiatry Rep 6:176-182.
40. Wilson GM, Flibotte S, Chopra V, Melnyk BL, Honer WG, Holt RA (2006). DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling. Hum Mol Genet 15:743-749.