Bioelectric effects of quinine on polarized airway epithelial cells

Journal of Cystic Fibrosis

Volumn 6, Issue 5, 2007, Pages 351-359

  Bates, Eleanor ^d   Miller, Stacey ^d   Alexander, Mariah ^d   Mazur, Marina ^d   Fortenberry, James A ^d   Bebok, Zsuzsa ^c,d   Sorscher, Eric J ^a,c,d   Rowe, Steven M ^a,b,c,d  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

CFTR; Cystic fibrosis; Placebo; Polarized epithelial monolayers; Quinine; Short circuit current

Indexed keywords

FORSKOLIN; QUININE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CHLORIDE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYSTIC FIBROSIS; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; ION CURRENT; RESPIRATORY EPITHELIUM; SHORT CIRCUIT CURRENT;

CELLS, CULTURED; CHLORIDES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HUMANS; PERMEABILITY; PLACEBOS; QUININE; RESPIRATORY SYSTEM;

EID: 34548284506     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcf.2007.01.001     Document Type: Article

References (28)

1. Rowe S.M., Miller S., and Sorscher E.J. Cystic fibrosis. N Engl J Med 352 19 (2005) 1992-2001
2. Saiman L., Marshall B.C., Mayer-Hamblett N., Burns J.L., Quittner A.L., Cibene D.A., et al. Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 290 13 (2003) 1749-1756
3. Fuchs H.J., Borowitz D.S., Christiansen D.H., Morris E.M., Nash M.L., Ramsey B.W., et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group. N Engl J Med 331 10 (1994) 637-642
4. Ramsey B.W., Pepe M.S., Quan J.M., Otto K.L., Montgomery A.B., Williams-Warren J., et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N Engl J Med 340 1 (1999) 23-30
5. Elkins M.R., Robinson M., Rose B.R., Harbour C., Moriarty C.P., Marks G.B., et al. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 354 3 (2006) 229-240
6. Donaldson S.H., Bennett W.D., Zeman K.L., Knowles M.R., Tarran R., and Boucher R.C. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 354 3 (2006) 241-250
7. Konstan M.W., Byard P.J., Hoppel C.L., and Davis P.B. Effect of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med 332 13 (1995) 848-854
8. Sorscher E.J., and Zabner J. Novel Therapeutic Approaches for CF Lung Disease. North American Cystic Fibrosis Conference. Workshop 23. vol. 23 (2004), St. Louis, MO
9. Ramsey B.W., Dorkin H.L., Eisenberg J.D., Gibson R.L., Harwood I.R., Kravitz R.M., et al. Efficacy of aerosolized tobramycin in patients with cystic fibrosis. N Engl J Med 328 24 (1993) 1740-1746
10. Bye P., Elkins M., Robinson M., Moriarty C., Rose B., and Harbour C. Long-term inhalation of hypertonic saline in patients with cystic fibrosis - a randomized controlled trial. Pediatr Pulmonol 38 S27 (2004) 329 [Abstract]
11. Scott T.R., and Plata-Salaman C.R. Taste in the monkey cortex. Physiol Behav 67 4 (1999) 489-511
12. Devor D.C., Bridges R.J., and Pilewski J.M. Pharmacological modulation of ion transport across wild-type and DeltaF508 CFTR-expressing human bronchial epithelia. Am J Physiol Cell Physiol 279 2 (2000) C461-C479
13. Imaizumi Y., and Giles W.R. Quinidine-induced inhibition of transient outward current in cardiac muscle. Am J Physiol 253 3 Pt 2 (1987) H704-H708
14. Gogelein H., and Capek K. Quinine inhibits chloride and nonselective cation channels in isolated rat distal colon cells. Biochim Biophys Acta 1027 2 (1990) 191-198
15. Varga K., Jurkuvenaite A., Wakefield J., Hong J.S., Guimbellot J.S., Venglarik C.J., et al. Efficient Intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines. J Biol Chem 279 21 (2004) 22578-22584
16. Bebok Z., Varga K., Hicks J.K., Venglarik C.J., Kovacs T., Chen L., et al. Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl-secretion in airway epithelia. J Biol Chem 277 45 (2002) 43041-43049
17. Iwatsuki N., and Petersen O.H. Inhibition of Ca2+-activated K+ channels in pig pancreatic acinar cells by Ba2+, Ca2+, quinine and quinidine. Biochim Biophys Acta 819 2 (1985) 249-257
18. Mancilla E., and Rojas E. Quinine blocks the high conductance, calcium-activated potassium channel in rat pancreatic beta-cells. FEBS Lett 260 1 (1990) 105-108
19. Richards N.W., and Dawson D.C. Single potassium channels blocked by lidocaine and quinidine in isolated turtle colon epithelial cells. Am J Physiol 251 1 Pt 1 (1986) C85-C89
20. Asgrimsson V., Gudjonsson T., Gudmundsson G.H., and Baldursson O. Novel effects of azithromycin on tight junction proteins in human airway epithelia. Antimicrob Agents Chemother 50 5 (2006) 1805-1812
21. Jornot L., Rochat T., and Lacroix J.S. Nasal polyps and middle turbinates epithelial cells sensitivity to amphotericin B. Rhinology 41 4 (2003) 201-205
22. Schmitz H., Fromm M., Bentzel C.J., Scholz P., Detjen K., Mankertz J., et al. Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci 112 Pt 1 (1999) 137-146
23. Alexandre M.D., Lu Q., and Chen Y.H. Overexpression of claudin-7 decreases the paracellular Cl-conductance and increases the paracellular Na+ conductance in LLC-PK1 cells. J Cell Sci Pt 12 118 (2005) 2683-2693
24. Gye M.C. Changes in the expression of claudins and transepithelial electrical resistance of mouse Sertoli cells by Leydig cell coculture. Int J Androl 26 5 (2003) 271-278
25. Van Itallie C.M., Fanning A.S., and Anderson J.M. Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Am J Physiol Renal Physiol 285 6 (2003) F1078-F1084
26. Colegio O.R., Van Itallie C., Rahner C., and Anderson J.M. Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 284 6 (2003) C1346-C1354
27. Schwiebert E.M., Morales M.M., Devidas S., Egan M.E., and Guggino W.B. Chloride channel and chloride conductance regulator domains of CFTR, the cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A 95 5 (1998) 2674-2679
28. Moss R.B. Administration of aerosolized antibiotics in cystic fibrosis patients. Chest 120 3 Suppl (2001) 107S-113S