Association of HLA DQ B1* and HLA DR B1* alleles with goitrous juvenile autoimmune hypothyroidism - A case control study

Journal of Clinical Immunology

Volumn 27, Issue 5, 2007, Pages 486-489

  Rekha, P L ^a   Valluri, Vijayalakshmi ^b   Rakh, Shilpa S ^c   Pantula, Vinod ^c   Ishaq, M ^a  

^a OSMANIA UNIVERSITY   (India)

^b LEPRA Society   (India)

^c Bhagwan Mahavir Medical Research Centre   (India)

Author keywords

Antimicrosomal antibody; Hashimoto's thyroiditis; HLA; Hypothyroidism; Juvenile autoimmune thyroiditis

Indexed keywords

HLA DQB1 ANTIGEN; HLA DR ANTIGEN; LIOTHYRONINE; THYROID HORMONE; THYROTROPIN; THYROXINE;

ADOLESCENT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; HLA SYSTEM; HUMAN; HYPOTHYROIDISM; INDIA; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; THYROID DISEASE; THYROID FUNCTION; THYROID FUNCTION TEST; THYROID HORMONE BLOOD LEVEL;

ADOLESCENT; ALLELES; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GRAVES DISEASE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; HYPOTHYROIDISM; MALE;

EID: 34548265234     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-007-9102-2     Document Type: Article

References (24)

1. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA: The spectrum of thyroid disease in a community: The Whickham survey. Clin Endocrinol (Oxf) 7:481-493, 1977
2. Wong FS, Wen L: The study of HLA class II and autoimmune diabetes. Curr Mol Med 3(1):1-15, 2003
3. Zanelli E, Breedveld FC, de Varies RRP: HLA association with autoimmune disease: A failure to protect? Rheumatology 39:1060-1066, 2000
4. Laivoranta-Nyman S, Möttönen T, Hermann R, Tuokko J, et al: HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis. Ann Rheum Dis 63:1406-1412, 2004
5. Luomala M, Elovaara I, Ukkonen M, Koivula T, Lehtimaki T: The combination of HLA-DR1 and HLA-DR53 protects against MS. Neurology 56:383-385, 2001
6. Morita K, Moriuchi J, Inoko H, Tsuji K, Arimori S: HLA class II antigens and DNA restriction fragment length polymorphism in myasthenia gravis in Japan. Ann Neurol 29:168-174, 1991
7. Yoshitake H, Kimura A, Okada M, Yao T, Sasazuki T: HLA class II alleles in Japanese patients with inflammatory bowel disease. Tissue Antigens 53:350-358, 1999
8. Dunston GM, Halder RM: Vitiligo is associated with HLA-DR4 in black patients. A preliminary report. Arch Dermatol 126:56-60, 1990
9. Nishimura Y, Kanai T, Oiso M, et al: Molecular analyses of HLA class II-associated susceptibility to subtypes of autoimmune diseases unique to Asians. Int J Cardiol 66:S93-104, 1998
10. Jenkins D, Penny MA, Fletcher JA, et al.: HLA class II gene polymorphism contributes little to Hashimoto's thyroiditis. MC Clin Endocrinol (Oxf) 37(2):141-145, 1992
11. Tandon N, Zhang L, Weetman AP: HLA associations with Hashimoto's thyroiditis. Clin Endocrinol (Oxf) 34(5):383-386, 1991
12. David HS, Samul R: Chapter 39 Thyroid function tests. In Endocrinology, 5th edn, Leslie J De Groot (ed), Vol 1. Philadelphia, WB Saunders, 2005
13. Abbas AK, Lichtman AH, Pober JS: Cellular and Molecular Immunology. Philadelphia, WB Saunders, 261, 1991
14. Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N: The association between HLA class II haplotype with Graves' disease in Thai population. Tissue Antigens 67(1):79, 2005
15. Farid NR, Sampson L, Moens H, Barnard JM: The association of goitrous autoimmune thyroiditis with HLA-DR5. Tissue Antigens 21:173-175, 1981
16. Hunt PJ, Marshall SE, Weetman AP, et al.: Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease. Clin Endocrinol (Oxf) 55:491-499, 2001
17. Petrone A, Giorgi G, Mesturino CA, et al.: Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population. Thyroid 11:171-175, 2001
18. Lervang HH, Pyrds O, Kristensen HP, Jakobsen BK, Svejgaard A: Postpartum autoimmune thyroid disorder associated with HLA-DR4? Tissue Antigens 23:250-252,1984
19. Pryds O, Lervang HH, Kristensen HP, Jakobsen BK, Svejgaard A: HLA-DR factors associated with postpartum hypothyroidism: An early manifestation of Hashimoto's thyroiditis? Tissue Antigens 30:34-37, 1987
20. Hunt PJ, Marshall SE, Weetman AP, et al.: Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmunethyroiddisease. Clin Endocrinol (Oxf) 55(4):491-499, 2001
21. Vargas MT, Briones-Urbina R, Gladman D, Papsin FR, Walfish PG: Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: Evidence supporting an autoimmune pathogenesis. J Clin Endocrinol Metab 67:327-333, 1988.
22. Zantut-Wittmann DE, Persoli L, Tambascia MA, et al.: HLA-DRB1*04 and HLA-DQB1*03 association with the atrophic but not with the goitrous form of chronic autoimmune thyroiditis in a Brazilianpopulation. Horm Metab Res 36(7):492-500, 2004
23. Maenpaa J, Lautenschlager I, Nyberg M, Koskimies S, Kontiainen S: Thyroid-infiltrating lymphocytes, thyroid function, and HLA-DR in juvenile autoimmune thyroiditis. Acta Endocrinol (Copenhagen) 121(4):573-577, 1989
24. Onuma H, Ota M, Sugenoya A, Fukushima H, Inoko H, Iida F: Association of HLA-DR53 and lack of association of DPB1 alleles with Hashimoto's thyroiditis (in Japanese). Tissue Antigens 42:150-152, 1993