SCOPUS 정보 검색 플랫폼

Journal of the American Chemical Society

Volumn 129, Issue 34, 2007, Pages 10330-10331

A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier

(2) Tsang, Wing Yin a Richard, John P a

a UNIVERSITY AT BUFFALO (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DEUTERIUM;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ISOTOPE ANALYSIS; METHODOLOGY; PROTON TRANSPORT; THERMODYNAMICS;

CARBON; DEUTERIUM; KINETICS; MOLECULAR STRUCTURE; PROTONS;

EID: 34548250959 PISSN: 00027863 EISSN: None Source Type: Journal
DOI: 10.1021/ja073679g Document Type: Article

Times cited : (18)

References (20)

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- Reactions were initiated by making a 1/100 dilution of the substrate in acetonitrile into 50/50 (v/v) H2O/D2O (1, 1.0, KCl) to give the following final concentrations and reaction 4-MeO-1, 0.3 mM in 25 mL; 1, 0.8 mM in 10 mL; 4-NO 2-1, 0.09 mM in 50 mL; and, 3,5-di-NO2-1, 0.06 mM in 50 mL. After 5-7 reaction halftimes, the organic product was extracted into CDCl3. The organic layer was dried by filtration through a short column of MgSO4 directly into an NMR tube, and the samples were stored at -15°C until being analyzed for deuterium content by 1H NMR. Control experiments with 3,5-di-NO2-1 were performed to show that the ketone reaction product is stable to base-catalyzed deuterium exchange of the α-methyl protons during acid-catalyzed hydrolysis of 3,5-di-NO2-1
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.