Characterization of a femoral segmental nonunion model in laboratory rats: Report of a novel surgical technique

Journal of Investigative Surgery

Volumn 20, Issue 4, 2007, Pages 249-255

  Russell, George ^a   Tucci, Michelle ^a   Conflitti, Joseph ^a   Graves, Matthew ^a   Wingerter, Scott ^a   Woodall Jr , James ^a   Ragab, Ashraf ^a   Benghuzzi, Hamed ^b  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Femoral plating; Fracture healing; Fracture model; Kirschner wires; Nonunion; Osteoinductive agents; Rat model; Segmental defect; Surgical techniques

Indexed keywords

STAINLESS STEEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALLUS; CONTROLLED STUDY; EXPERIMENTAL RAT; FEMUR FRACTURE; FOLLOW UP; FRACTURE FIXATION; FRACTURE HEALING; FRACTURE NONUNION; KIRSCHNER WIRE; NONHUMAN; OSSIFICATION; OSTEOTOMY; PRIORITY JOURNAL; RAT; SURGICAL TECHNIQUE; WEIGHT BEARING;

ANIMALS; BONE PLATES; FEMORAL FRACTURES; FRACTURE HEALING; FRACTURES, MALUNITED; MALE; MODELS, ANATOMIC; OSTEOGENESIS; OSTEOTOMY; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT-BEARING;

EID: 34548237860     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.1080/08941930701481312     Document Type: Article

References (14)

1. Dzugan, S. (2005) Sustained release of OP-1 and antibiotics in treatment of femoral defects in male rats. Biomed Sci Instrum., 41, pp. 80-85.
2. Galjour, C. (2005) Stimulation of fracture healing by continuous delivery of demineralized bone matrix proteins and tobramycin. Biomed Sci Instrum., 41, pp. 122-127.
3. Einhorn, T.A. (1984) The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study. J Bone Joint Surg Am., 66:2, pp. 274-279.
4. Kitsugi, T., Yamamuro, T. and Kokubo, T. (1989) Bonding behavior of a glass-ceramic containing apatite and wollastonite in segmental replacement of the rabbit tibia under load-bearing conditions. J Bone Joint Surg Am., 71:2, pp. 264-272.
5. Kokubu, T. (2003) Development of an atrophic nonunion model and comparison to a closed healing fracture in rat femur. J Orthop Res., 21:3, pp. 503-510.
6. Tuominen, T. (2000) Native bovine bone morphogenetic protein improves the potential of biocoral to heal segmental canine ulnar defects. Int Orthop., 24:5, pp. 289-294.
7. Viljanen, J. (1997) Absorbable polylactide pins versus metallic Kirschner wires in the fixation of cancellous bone osteotomies in rats. Ann Chir Gynaecol., 86:1, pp. 66-73.
8. Grundnes, O. and Reikeras, O. (1991) Mechanical effects of function on bone healing. Nonweight bearing and exercise in osteotomized rats. Acta Orthop Scand., 62:2, pp. 163-165.
9. Hunt, T.R., Schwappach, J.R. and Anderson, H.C. (1996) Healing of a segmental defect in the rat femur with use of an extract from a cultured human osteosarcoma cell-line (Saos-2). A preliminary report. J Bone Joint Surg Am., 78:1, pp. 41-48.
10. Benghuzzi, H.A., Barbaro, R.M. and Bajpai, P.K. (1989) Sustained delivery of 3H-thymidine by means of ceramic capsules in rats. Biomed Sci Instrum, 25, pp. 169-177.
11. Ryhanen, J. (1999) Bone healing and mineralization, implant corrosion, and trace metals after nickel-titanium shape memory metal intramedullary fixation. J Biomed Mater Res., 47:4, pp. 472-480.
12. Probst, A. (1999) Callus formation and fixation rigidity: A fracture model in rats. J Orthop Res., 17:2, pp. 256-260.
13. Reikeras, O. (1990) Healing of osteotomies under different degrees of stability in rats. J Orthop Trauma., 4:2, pp. 175-178.
14. Lins, R.E. (1996) A comparative mechanical analysis of plate fixation in a proximal phalangeal fracture model. J Hand Surg [Am]., 21:6, pp. 1059-1064.